Neural - Rhombencephalon Development: Difference between revisions
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==Some Recent Findings== | ==Some Recent Findings== | ||
[[File:Mouse - rhombomere boundaries.jpg|thumb|300px|Mouse - rhombomere boundaries<ref name="PMID20404937"><pubmed>20404937</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853563 PMC2853563] | [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0010112 PLoS One.]</ref> | |||
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* '''Clonal analysis in mice underlines the importance of rhombomeric boundaries in cell movement restriction during hindbrain segmentation'''<ref><pubmed>20404937</pubmed></ref> "Our results show that the compartment border coincides with the morphological boundary in the mouse hindbrain. The restriction of the cells to cross rhombomeric boundaries seen in chick is also observed in mouse. We show that the rhombomeric boundaries themselves are involved in cell movement restriction, although an underlying pre-pattern during early embryonic development might influence the way that cell populations organize." | * '''Clonal analysis in mice underlines the importance of rhombomeric boundaries in cell movement restriction during hindbrain segmentation'''<ref name="PMID20404937"><pubmed>20404937</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853563 PMC2853563] | [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0010112 PLoS One.]</ref> "Our results show that the compartment border coincides with the morphological boundary in the mouse hindbrain. The restriction of the cells to cross rhombomeric boundaries seen in chick is also observed in mouse. We show that the rhombomeric boundaries themselves are involved in cell movement restriction, although an underlying pre-pattern during early embryonic development might influence the way that cell populations organize." | ||
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Revision as of 12:43, 8 November 2010
Introduction
Neural development is one of the earliest systems to begin and the last to be completed after birth. This development generates the most complex structure within the embryo and the long time period of development means in utero insult during pregnancy may have consequences to development of the nervous system.
The early central nervous system begins as a simple neural plate that folds to form a groove then tube, open initially at each end. Failure of these opening to close contributes a major class of neural abnormalities (neural tube defects).
Within the neural tube stem cells generate the 2 major classes of cells that make the majority of the nervous system : neurons and glia. Both these classes of cells differentiate into many different types generated with highly specialized functions and shapes. This section covers the establishment of neural populations, the inductive influences of surrounding tissues and the sequential generation of neurons establishing the layered structure seen in the brain and spinal cord.
- Neural development beginnings quite early, therefore also look at notes covering Week 3- neural tube and Week 4-early nervous system.
- Development of the neural crest and sensory systems (hearing/vision/smell) are only introduced in these notes and are covered in other notes sections.
Some Recent Findings
[[File:Mouse - rhombomere boundaries.jpg|thumb|300px|Mouse - rhombomere boundaries[1]
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Development Overview
Neuralation begins at the trilaminar embryo with formation of the notochord and somites, both of which underly the ectoderm and do not contribute to the nervous system, but are involved with patterning its initial formation. The central portion of the ectoderm then forms the neural plate that folds to form the neural tube, that will eventually form the entire central nervous system.
- Early developmental sequence: Epiblast - Ectoderm - Neural Plate - Neural groove and Neural Crest - Neural Tube and Neural Crest
Neural Tube | Primary Vesicles | Secondary Vesicles | Adult Structures |
---|---|---|---|
week 3 | week 4 | week 5 | adult |
prosencephalon (forebrain) | telencephalon | Rhinencephalon, Amygdala, hippocampus, cerebrum (cortex), hypothalamus, pituitary | Basal Ganglia, lateral ventricles | |
diencephalon | epithalamus, thalamus, Subthalamus, pineal, posterior commissure, pretectum, third ventricle | ||
mesencephalon (midbrain) | mesencephalon | tectum, Cerebral peduncle, cerebral aqueduct, pons | |
rhombencephalon (hindbrain) | metencephalon | cerebellum | |
myelencephalon | medulla oblongata, isthmus | ||
spinal cord, pyramidal decussation, central canal |
Primary Vesicles
[[File:Stage 13 image 098.jpg|thumb|300px|Brain primary vesicle development (Carnegie stage 13)]]
References
- ↑ 1.0 1.1 <pubmed>20404937</pubmed>| PMC2853563 | PLoS One.
Reviews
<pubmed>19206138</pubmed>
Articles
Search PubMed
Search Pubmed: Rhombencephalon Embryology | Rhombencephalon Development |
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2024, May 23) Embryology Neural - Rhombencephalon Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Neural_-_Rhombencephalon_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G