Rabbit Development: Difference between revisions
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* 2 weeks was 38% of adult | * 2 weeks was 38% of adult | ||
* 16 weeks was 94% of adult | * 16 weeks was 94% of adult | ||
==Rabbit Immune Development== | |||
Rabbits generate their antibody repertoire in three stages.<ref>Development of the antibody repertoire in rabbit: gut-associated lymphoid tissue, microbes, and selection. Lanning D, Zhu X, Zhai SK, Knight KL. Immunol Rev. 2000 Jun;175:214-28. Review. [http://www.ncbi.nlm.nih.gov/pubmed/10933605 PMID: 10933605]</ref> | |||
# Neonatal repertoire is generated by B lymphopoiesis in fetal liver and bone marrow (limited by preferential V(H) gene segment usage). | |||
# Between 4 and 8 weeks after birth gut-associated lymphoid tissue (GALT) a complex primary antibody repertoire. | |||
# The primary antibody repertoire is subsequently modified during antigen-dependent immune responses (the secondary repertoire). | |||
Rabbits uniquely develop a primary antibody repertoire through somatic diversification of Ig genes (dependent on intestinal microbial flora). | |||
==References== | ==References== |
Revision as of 23:26, 28 March 2010
Introduction
As an embryological tool, the rabbit (Taxon- Oryctolagus cuniculus) along with human was a species which show birth defects with thalidomide (teratogenic effects not detected with prior testing on other species). These animals are herbivores with a very high breeding rate and number of offspring produced.
Links: 2009 ANAT2341 Group Project - Rabbit | Original Rabbit page
Taxon
Oryctolagus cuniculus
Taxonomy Id: 9986 Rank: species
Genetic code: Translation table 1 (Standard) Mitochondrial genetic code: Translation table 2 Other names: New Zealand rabbit[includes], rabbits[common name], European rabbit[common name], Japanese white rabbit[common name], domestic rabbit[common name], rabbit[common name], Lepus cuniculus[misnomer]
Lineage( abbreviated ): Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Lagomorpha; Leporidae; Oryctolagus
Rabbit Placentation
Rabbit implantation and placentation is a centric (or fusion) type, where the blastocyst adheres only to the epithelial cells (apical region) by trophectoderm forming projections.[1]
Postnatal Rabbit Growth
Postnatal growth data from 2 to 34 weeks of age at biweekly intervals for New Zealand white rabbit. [2]
- 17 male and 12 female rabbits, with the data tabulated separately.
- Skeletal growth was complete at 28 weeks, with the 34 week values mature adult lengths.
Mean body weight
- 2 weeks of age was 6% that at 34 weeks
- 16 weeks was 72% of the weight at 34 weeks
- weight continued to increase in the adult.
Mean body length
- 2 weeks was 40% that at 34 weeks
- 16 weeks was 91% of mature adult
Mean femoral length
- 2 weeks was 38% of adult
- 16 weeks was 95% of adult
Mean tibial length
- 2 weeks was 38% of adult
- 16 weeks was 94% of adult
Rabbit Immune Development
Rabbits generate their antibody repertoire in three stages.[3]
- Neonatal repertoire is generated by B lymphopoiesis in fetal liver and bone marrow (limited by preferential V(H) gene segment usage).
- Between 4 and 8 weeks after birth gut-associated lymphoid tissue (GALT) a complex primary antibody repertoire.
- The primary antibody repertoire is subsequently modified during antigen-dependent immune responses (the secondary repertoire).
Rabbits uniquely develop a primary antibody repertoire through somatic diversification of Ig genes (dependent on intestinal microbial flora).
References
- ↑ Animal models of implantation. Lee KY, DeMayo FJ. Reproduction. 2004 Dec;128(6):679-95. Review. PMID: 15579585
- ↑ A longitudinal study of the growth of the New Zealand white rabbit: cumulative and biweekly incremental growth rates for body length, body weight, femoral length, and tibial length. Masoud I, Shapiro F, Kent R, Moses A. J Orthop Res. 1986;4(2):221-31. PMID: 3712130
- ↑ Development of the antibody repertoire in rabbit: gut-associated lymphoid tissue, microbes, and selection. Lanning D, Zhu X, Zhai SK, Knight KL. Immunol Rev. 2000 Jun;175:214-28. Review. PMID: 10933605
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Cite this page: Hill, M.A. (2024, June 27) Embryology Rabbit Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Rabbit_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G