Fly Development: Difference between revisions
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'''Developmental Dynamics''' | '''Developmental Dynamics''' | ||
* [http:// | * [http://onlinelibrary.wiley.com/doi/10.1002/dvdy.v232:3/issuetoc Special Issue Drosophila as a Model System] | ||
'''Journal of Neurobiology''' | '''Journal of Neurobiology''' |
Revision as of 16:23, 7 June 2011
Introduction
This page introduces the fly, drosophila, as a developmental model organism. The small drosophila fruitfly has been used by genetisists for many years now and much is now understood about its development in relation to gene expression and regulatory mechanisms.
In recent years, using developmental mutants, many mechanisms of development in the fly have been shown to be almost identical to those seen in humans and other animals. In fact, these developmental mechanisms have become the "paradigm" for our understanding of development.
The fruitfly (drosophila) was and is the traditional geneticist's tool. It has been transformed to an magnificent tool for the embryologist, with many developmental mechanisms being uncovered in this system combined with homolgy gene searches in other species.
2009 ANAT2341 Group Project - Fly
Some Recent Findings
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Taxon
melanogaster group
Taxonomy Id: 32346 Rank: species group
Genetic code: Translation table 1 (Standard) Mitochondrial genetic code: Translation table 5 Lineage( abbreviated ): Eukaryota; Metazoa; Arthropoda; Tracheata; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila
Development
The drosophila lifespan varies with temperature and is about 30 days at 29 °C.
Hox Genes
Fly wild-type head[4] | Fly antennapedia mutant head[4] |
This is the classic mutation that gave rise to the discovery of Hox genes and other genes related to body pattern formation. In this mutant during development the fly embryo incorrectly positioned where (antenna) should have be two legs (pedia)[4]. The discovery of this mutant in Walter Gehring's lab opened up the field of developmental genes and this field has been rewarded with the 1995 Nobel prize in Medicine.
Neural Development
Summary of neural development from neural stem cell population and the gene regulation involved.[2]
References
Journals
Developmental Dynamics
Journal of Neurobiology
- Special Issue: Unexpected Roles for Morphogens in the Development and Regeneration of the CNS Volume 64, Issue 4 (15 September 2005)
- Marques G. Morphogens and synaptogenesis in Drosophila. J Neurobiol. 2005 Sep 15;64(4):417-34.
Online Textbooks
Molecular Biology of the Cell (4th Edn) Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin; Roberts, Keith; Walter, Peter. New York: Garland Publishing; 2002.
- Figure 21-24. Synopsis of Drosophila development from egg to adult fly
- Drosophila Begins Its Development as a Syncytium
- Figure 21-2. Homologous proteins functioning interchangeably in the development of mice and flies
Developmental Biology (6th Edn) Gilbert, Scott F. Sunderland (MA): Sinauer Associates, Inc.; c2000.
- Early Drosophila Development
- Snapshot Summary: Drosophila Development and Axis Specification
- Limb formation
Search NLM Online Textbooks- "drosophila development" : Molecular Biology of the Cell | Molecular Cell Biology | The Cell- A molecular Approach
Reviews
<pubmed>15704150</pubmed> <pubmed>15261654</pubmed> <pubmed>14699588</pubmed> <pubmed>12801722</pubmed>
Articles
<pubmed>16086608</pubmed>
Search PubMed
Search Aug2005 "drosophila development" 13228 reference articles of which 1899 were reviews.
Search Pubmed: fly development | drosophila development
External Links
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
Databases
There are a number of excellent internet resources for Fly development.
- Flybase - A Database of the Drosophila Genome http://flybase.bio.indiana.edu/
- The Interactive Fly - looks at genes and development http://www.sdbonline.org/fly/aimain/1aahome.htm This site is very well organized and allows an exploration of the molecular mechanisms of development. Remember that this is where molecular mammalian embryology all started through homology.
- Flybrain - An Online Atlas and Database of the Drosophila Nervous System http://flybrain.neurobio.arizona.edu/
- FlyServer - A Drosophila Image Database and A Drosophila Multimedia Database http://pbio07.uni-muenster.de/
- NCBI Taxonomy Browser | Drosophila Genome Resources
Fly Pages
- Development of Drosophila - by Katherine Plewes, Becky Wong and Leon W. Browder http://www.ucalgary.ca/UofC/eduweb/virtualembryo/flies.html
- BIO 114 Virtual Fly - lntroductory Biology Lab course at the WKU Glasgow extended campus http://bioweb.wku.edu/courses/Biol114/Vfly1.asp
- Chapter 13A: Drosophila Development - Kenyon College http://biology.kenyon.edu/courses/biol114/Chap13/Chapter_13A.html
- Journal of Visualized Experiments Live Imaging Of Drosophila melanogaster Embryonic Hemocyte Migrations
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Cite this page: Hill, M.A. (2024, June 10) Embryology Fly Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Fly_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G