Paper - A fifteen-somite human embryo

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Mizoguti H. A fifteen-somite human embryo. (1989) Adv Anat Embryol Cell Biol. 116:1-102. PMID: 2610025

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This historic 1989 paper by Mizoguti describes a human embryo with 15 somites corresponding to Carnegie stage 11 during week 4.



Modern Notes:

Stage 11 Links: Week 4 | Somitogenesis | Placodes | Lecture - Mesoderm | Lecture - Ectoderm | Lecture - Early Vascular | Science Practical | Carnegie Embryos | Category:Carnegie Stage 11 | Next Stage 12
  Historic Papers: 1908 | 1920 | 1923 somites 20 | 1927 Heart | 1928 somites 17-23 | 1959 stage 11 | 1964 dysraphism
Week: 1 2 3 4 5 6 7 8
Carnegie stage: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
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Pages where the terms "Historic Textbook" and "Historic Embryology" appear on this site, and sections within pages where this disclaimer appears, indicate that the content and scientific understanding are specific to the time of publication. This means that while some scientific descriptions are still accurate, the terminology and interpretation of the developmental mechanisms reflect the understanding at the time of original publication and those of the preceding periods, these terms and interpretations may not reflect our current scientific understanding.     (More? Embryology History | Historic Embryology Papers)

A Fifteen-Somite Human Embryo

Mizoguti H.

Abstract

The morphological features of a well-preserved human embryo having 15 pairs of somites are described and illustrated with a complete set of photomicrographs.

This embryo was found during a forensic dissection of a Japanese woman, fixed in 10% formalin for 5 days, and embedded in an epoxy resin mixture according to routine procedures. Serial sections about 0.75 microns thick were made and stained with toluidine blue.

The most important features were as follows:

  1. The embryo measured 4.1 mm in greatest length and was quite symmetrical viewed dorsally.
  2. Closure of the neural tube took place from the level of the first branchial groove, corresponding to the level of the anterior one-third of the rhombencephalon, to that of about 0.4 mm posterior to the 15th somite, coming across the anterior end of the cloacal membrane. The neural plate and the wall of the neural tube consisted exclusively of a pseudostratified columnar epithelium, and neither the mantle nor marginal layers were identified anywhere.
  3. At the anterior end of the embryo there was a conspicuous optic evagination, and at the dorsal end of the second branchial groove a round otic placode.
  4. Of the three segments of the entodermal tract the midgut was the largest, constituting about half the entire length, and opened ventrally into the large yolk sac, whose surface was covered by a meshwork of highly developed blood vessels. In the foregut two branchial pouches were seen, corresponding to the branchial grooves. Primordia of the thyroid gland and of the liver were also recognized. Among the entodermal epithelial cells lining the ventral half of the hindgut anterior to the origin of the allantois were found numerous primordial germ cells.
  5. Among the 15 pairs of somites, the first two were small and consisted of dermomyotome of epithelial cell arrangement and of sclerotome mingled into mesenchyme. The next three were large, triangular on transverse section, and consisted of dorsolateral dermomyotome and ventromedial sclerotome representing a densely packed mesenchymal cell aggregation. The sixth to the tenth somites showed a well-defined triangular contour, each containing a lumen, the myocoele. The last five somites were progressively smaller and were quadrangular in shape.
  6. The intermediate mesoderm was encountered at levels from the 7th to the 15th somite, but no indications of pronephric differentiation were detected.
  7. The heart tube was relatively large, took an S-shaped tortuous course, and occupied almost the entire pericardiac cavity. It consisted of the bulbus cordis, the ventriculus, and the atrium, each of which consisted of a thick myocardial tube and a thin endocardial tube.

Cite this page: Hill, M.A. (2019, August 20) Embryology Paper - A fifteen-somite human embryo. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Paper_-_A_fifteen-somite_human_embryo

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