Neural - Tectum Development
|Embryology - 2 Jul 2020 Expand to Translate|
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|A personal message from Dr Mark Hill (May 2020)|
|contributors to the site. The good news is Embryology will remain online and I will continue my association with UNSW Australia. I look forward to updating and including the many exciting new discoveries in Embryology!|
Neural development is one of the earliest systems to begin and the last to be completed after birth. This development generates the most complex structure within the embryo and the long time period of development means in utero insult during pregnancy may have consequences to development of the nervous system.
Differences between birds and mammals:
- both - have retinal axons projecting topographically to targets in the brain.
- birds - the visual fibers from the entire retina decussate at the optic chiasm.
- mammals - some axons from the temporal retina diverge at the midline to project ipsilaterally.
Neural development beginnings quite early, therefore also look at notes covering Week 3- neural tube and Week 4-early nervous system. Development of the neural crest and sensory systems (hearing/vision/smell) are only introduced in these notes and are covered in other notes sections.
Some Recent Findings
|More recent papers|
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
Search term: Tectum Embryology
<pubmed limit=5>Tectum Embryology</pubmed>
Developmental Signaling Model
Model of interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development. 
Neuralation begins at the trilaminar embryo with formation of the notochord and somites, both of which underly the ectoderm and do not contribute to the nervous system, but are involved with patterning its initial formation. The central portion of the ectoderm then forms the neural plate that folds to form the neural tube, that will eventually form the entire central nervous system.
- Early developmental sequence: Epiblast - Ectoderm - Neural Plate - Neural groove and Neural Crest - Neural Tube and Neural Crest
|Neural Tube||Primary Vesicles||Secondary Vesicles||Adult Structures|
|week 3||week 4||week 5||adult|
|prosencephalon (forebrain)||telencephalon||Rhinencephalon, Amygdala, hippocampus, cerebrum (cortex), hypothalamus, pituitary | Basal Ganglia, lateral ventricles|
|diencephalon||epithalamus, thalamus, Subthalamus, pineal, posterior commissure, pretectum, third ventricle|
|mesencephalon (midbrain)||mesencephalon||tectum, Cerebral peduncle, cerebral aqueduct, pons|
|myelencephalon||medulla oblongata, isthmus|
|spinal cord, pyramidal decussation, central canal|
Early Brain Vesicles
Model of molecular interactions during dorsal midbrain development
|Model for a possible cooperation of Meis2, Pax3, Pax7 and Otx2 during tectal development.
Red lines indicate negative regulation, green arrows positive regulation. Dashed lines indicate hypothetical direct regulation of the Meis2 promoter/enhancer by different Pax3 concentrations. Solid lines indicate indirect regulation of Meis2 expression via Pax3/7 mediated induction of Fgf8 as previously reported:
- drebrin E - (5q35.3) widespread but not ubiquitous cell types in various tissues.
- drebrin A - adult brain neuron-specific, concentrated in dendritic spines, and its accumulation level is regulated by synaptic activity.
- OMIM: DBN1 drebrin E
- Watanabe Y, Sakuma C & Yaginuma H. (2018). Dispersing movement of tangential neuronal migration in superficial layers of the developing chick optic tectum. Dev. Biol. , 437, 131-139. PMID: 29548944 DOI.
- Yang C, Li X, Li Q, Li H, Qiao L, Guo Z & Lin J. (2018). Sonic Hedgehog Regulation of the Neural Precursor Cell Fate During Chicken Optic Tectum Development. J. Mol. Neurosci. , 64, 287-299. PMID: 29285739 DOI.
- Agoston Z, Li N, Haslinger A, Wizenmann A & Schulte D. (2012). Genetic and physical interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development. BMC Dev. Biol. , 12, 10. PMID: 22390724 DOI.
- Pyrgaki C, Trainor P, Hadjantonakis AK & Niswander L. (2010). Dynamic imaging of mammalian neural tube closure. Dev. Biol. , 344, 941-7. PMID: 20558153 DOI.
- Shirao T & Sekino Y. (2017). General Introduction to Drebrin. Adv. Exp. Med. Biol. , 1006, 3-22. PMID: 28865011 DOI.
Marachlian E, Avitan L, Goodhill GJ & Sumbre G. (2018). Principles of Functional Circuit Connectivity: Insights From Spontaneous Activity in the Zebrafish Optic Tectum. Front Neural Circuits , 12, 46. PMID: 29977193 DOI.
Joly JS, Recher G, Brombin A, Ngo K & Hartenstein V. (2016). A Conserved Developmental Mechanism Builds Complex Visual Systems in Insects and Vertebrates. Curr. Biol. , 26, R1001-R1009. PMID: 27780043 DOI.
Zhaoping L. (2016). From the optic tectum to the primary visual cortex: migration through evolution of the saliency map for exogenous attentional guidance. Curr. Opin. Neurobiol. , 40, 94-102. PMID: 27420378 DOI.
Saitsu H & Shiota K. (2008). Involvement of the axially condensed tail bud mesenchyme in normal and abnormal human posterior neural tube development. Congenit Anom (Kyoto) , 48, 1-6. PMID: 18230116 DOI.
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Cite this page: Hill, M.A. (2020, July 2) Embryology Neural - Tectum Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Neural_-_Tectum_Development
- © Dr Mark Hill 2020, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G