Neural - Tectum Development
|Embryology - 10 Dec 2018 Expand to Translate|
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Neural development is one of the earliest systems to begin and the last to be completed after birth. This development generates the most complex structure within the embryo and the long time period of development means in utero insult during pregnancy may have consequences to development of the nervous system.
Differences between birds and mammals:
- both - have retinal axons projecting topographically to targets in the brain.
- birds - the visual fibers from the entire retina decussate at the optic chiasm.
- mammals - some axons from the temporal retina diverge at the midline to project ipsilaterally.
Neural development beginnings quite early, therefore also look at notes covering Week 3- neural tube and Week 4-early nervous system. Development of the neural crest and sensory systems (hearing/vision/smell) are only introduced in these notes and are covered in other notes sections.
- Neural Parts: neural | prosencephalon | telencephalon cerebrum | amygdala | hippocampus | basal ganglia | lateral ventricles | diencephalon | Epithalamus | thalamus | hypothalamus | pituitary | pineal | third ventricle | mesencephalon | tectum | cerebral aqueduct | rhombencephalon | metencephalon | pons | cerebellum | myelencephalon | medulla oblongata | spinal cord | neural vascular | meninges | Category:Neural
Some Recent Findings
|More recent papers|
This table shows an automated computer PubMed search using the listed sub-heading term.
References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.
Yuji Watanabe, Chie Sakuma, Hiroyuki Yaginuma Visualization of Tangential Cell Migration in the Developing Chick Optic Tectum. J Vis Exp: 2018, (140); PubMed 30417886
Yuji Watanabe, Chie Sakuma, Hiroyuki Yaginuma Dispersing movement of tangential neuronal migration in superficial layers of the developing chick optic tectum. Dev. Biol.: 2018; PubMed 29548944
Stéphanie Bouffard, Emilie Dambroise, Alessandro Brombin, Sylvain Lempereur, Isabelle Hatin, Matthieu Simion, Raphaël Corre, Franck Bourrat, Jean-Stéphane Joly, Françoise Jamen Fibrillarin is essential for S-phase progression and neuronal differentiation in zebrafish dorsal midbrain and retina. Dev. Biol.: 2018, 437(1);1-16 PubMed 29477341
Luciano A Favorito, Helce Riberio Julio-Junior, Francisco J Sampaio Relationship between Undescended Testis Position and Prevalence of Testicular Appendices, Epididymal Anomalies, and Patency of Processus Vaginalis. Biomed Res Int: 2017, 2017;5926370 PubMed 29445742
Ciqing Yang, Xiaoying Li, Qiuling Li, Han Li, Liang Qiao, Zhikun Guo, Juntang Lin Sonic Hedgehog Regulation of the Neural Precursor Cell Fate During Chicken Optic Tectum Development. J. Mol. Neurosci.: 2017; PubMed 29285739
Developmental Signaling Model
Model of interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development. 
Neuralation begins at the trilaminar embryo with formation of the notochord and somites, both of which underly the ectoderm and do not contribute to the nervous system, but are involved with patterning its initial formation. The central portion of the ectoderm then forms the neural plate that folds to form the neural tube, that will eventually form the entire central nervous system.
- Early developmental sequence: Epiblast - Ectoderm - Neural Plate - Neural groove and Neural Crest - Neural Tube and Neural Crest
|Neural Tube||Primary Vesicles||Secondary Vesicles||Adult Structures|
|week 3||week 4||week 5||adult|
|Prosencephalon||Telencephalon||Rhinencephalon, Amygdala, Hippocampus, Cerebrum (Cortex), Hypothalamus, Pituitary | Basal Ganglia, lateral ventricles|
|Diencephalon||Epithalamus, Thalamus, Subthalamus, Pineal, third ventricle|
|Mesencephalon||Mesencephalon||Tectum, Cerebral peduncle, Pretectum, cerebral aqueduct|
Early Brain Vesicles
Model of molecular interactions during dorsal midbrain development
| Model for a possible cooperation of Meis2, Pax3, Pax7 and Otx2 during tectal development.
Red lines indicate negative regulation, green arrows positive regulation. Dashed lines indicate hypothetical direct regulation of the Meis2 promoter/enhancer by different Pax3 concentrations. Solid lines indicate indirect regulation of Meis2 expression via Pax3/7 mediated induction of Fgf8 as previously reported:
- drebrin E - (5q35.3) widespread but not ubiquitous cell types in various tissues.
- drebrin A - adult brain neuron-specific, concentrated in dendritic spines, and its accumulation level is regulated by synaptic activity.
- OMIM: DBN1 drebrin E
- Watanabe Y, Sakuma C & Yaginuma H. (2018). Dispersing movement of tangential neuronal migration in superficial layers of the developing chick optic tectum. Dev. Biol. , 437, 131-139. PMID: 29548944 DOI.
- Yang C, Li X, Li Q, Li H, Qiao L, Guo Z & Lin J. (2018). Sonic Hedgehog Regulation of the Neural Precursor Cell Fate During Chicken Optic Tectum Development. J. Mol. Neurosci. , 64, 287-299. PMID: 29285739 DOI.
- Agoston Z, Li N, Haslinger A, Wizenmann A & Schulte D. (2012). Genetic and physical interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development. BMC Dev. Biol. , 12, 10. PMID: 22390724 DOI.
- Pyrgaki C, Trainor P, Hadjantonakis AK & Niswander L. (2010). Dynamic imaging of mammalian neural tube closure. Dev. Biol. , 344, 941-7. PMID: 20558153 DOI.
- Shirao T & Sekino Y. (2017). General Introduction to Drebrin. Adv. Exp. Med. Biol. , 1006, 3-22. PMID: 28865011 DOI.
Marachlian E, Avitan L, Goodhill GJ & Sumbre G. (2018). Principles of Functional Circuit Connectivity: Insights From Spontaneous Activity in the Zebrafish Optic Tectum. Front Neural Circuits , 12, 46. PMID: 29977193 DOI.
Joly JS, Recher G, Brombin A, Ngo K & Hartenstein V. (2016). A Conserved Developmental Mechanism Builds Complex Visual Systems in Insects and Vertebrates. Curr. Biol. , 26, R1001-R1009. PMID: 27780043 DOI.
Zhaoping L. (2016). From the optic tectum to the primary visual cortex: migration through evolution of the saliency map for exogenous attentional guidance. Curr. Opin. Neurobiol. , 40, 94-102. PMID: 27420378 DOI.
Saitsu H & Shiota K. (2008). Involvement of the axially condensed tail bud mesenchyme in normal and abnormal human posterior neural tube development. Congenit Anom (Kyoto) , 48, 1-6. PMID: 18230116 DOI.
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Cite this page: Hill, M.A. (2018, December 10) Embryology Neural - Tectum Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Neural_-_Tectum_Development
- © Dr Mark Hill 2018, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G