Endocrine System Development

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Human adrenal gland (Week 10)
Adult endocrine organs

The endocrine system resides within specific endocrine organs and both organs and tissues with other specific functions. Epithelia (ectoderm and endoderm) form the majority of the “ductless” endocrine glands like gastrointestinal and skin associated “ducted” glands. Differentiation of several also organs involves a epithelial/mesenchye interaction, seen in repeated in many differentiation of many different tissues. The endocrine glands produce hormones, which are distributed by the vascular system to the many body tissues, subsequently these organs are richly vascularized.

Hormones are recognised by either cell surface receptors (modified amino acids, peptides, proteins) or cytoplasmic/nuclear receptors (steroids). Hormones “orchestrate” responses in other tissues, including other endocrine organs, and these overall effects can be similar or different in different tissues. In addition, these hormone effects (like music) can be rapid, slow, brief, diurnal, or long-term. Hormone effects can be mimicked, stimulated, and blocked by therapeutic drugs, nutritional and environmental chemicals.

The human fetus is dependent upon endocrine development for hormones, which support normal development. Peripheral endocrine glands (thyroid, pancreas, adrenals, gonads) form early in the second month from epithelial/mesenchye interactions and differentiate into the third month. The fetus also has a unique hormonal system that combines not only its own developing endocrine system, but also that of the corpus luteum, placenta and maternal hormones.

Abnormal endocrine development/function can impact on many different systems. For example, insufficient maternal dietary iodine impacts on fetal thyroid gland thyroid hormone production, which in turn can lead to abnormal neural development. Alternatively, we now know many environmental and therapeutic chemicals have a wide range of effects on the endocrine system.

Sex hormones from the gonads have significant effects prenatally and postnatally, specifically at puberty with a role to play in male/female biological maturity and have wide actions throughout the body.

This current page provides a general introduction to the endocrine system, use the links below to explore development of specific endocrine organs.

Endocrine Links: Introduction | BGD Lecture | Science Lecture | Pineal | Hypothalamus‎ | Pituitary | Thyroid | Parathyroid | Thymus‎ | Pancreas‎ | Adrenal‎ | Gonad‎ | Placenta‎ | Other Tissues | Stage 22 | Abnormalities | Hormones | Category:Endocrine
Historic Embryology  
1912 Chromaffin Organs and of the Suprarenal Bodies | 1914 Suprarenal System of Organs

Pineal gland position.jpg


Stage 22 image 055.jpg




Pharyngeal pouches.jpg


Stage 22 image 169.jpg


Pancreas adult.jpg


Some Recent Findings

  • Endocrine Pancreas[1] "The transcription factor Pax6 functions in the specification and maintenance of the differentiated cell lineages in the endocrine pancreas. It has two DNA binding domains, the paired domain and the homeodomain, in addition to a C-terminal transactivation domain. The phenotype of Pax6-/- knockout mice suggests non-redundant functions of the transcription factor in the development of glucagon-expressing alpha-cells as this cell type is absent in the mutants."
  • Pituitary Gland Development[2] recent review article looking at molecular mechanisms of development.
More recent papers  
Mark Hill.jpg
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This table shows an automated computer PubMed search using the listed sub-heading term.

  • Therefore the list of references do not reflect any editorial selection of material based on content or relevance.
  • References appear in this list based upon the date of the actual page viewing.

References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.

Links: References | Discussion Page | Pubmed Most Recent | Journal Searches

Search term: Endocrine Embryology

Oliwia Anna Segiet, Mariusz Deska, Łukasz Mielańczyk, Marlena Brzozowa-Zasada, Grzegorz Buła, Jacek Gawrychowski, Romuald Wojnicz Expression of TRAIL and Fas in Primary Hyperparathyroidism. J Invest Surg: 2016;1-5 PubMed 27763797

Jae-Hwan Lee, Changhwan Ahn, Hee Young Kang, Eui-Ju Hong, Sang-Hwan Hyun, Kyung-Chul Choi, Eui-Bae Jeung Effects of Octylphenol and Bisphenol A on the Metal Cation Transporter Channels of Mouse Placentas. Int J Environ Res Public Health: 2016, 13(10); PubMed 27690074

Célia Lopes, Tânia Vieira Madureira, Nádia Ferreira, Ivone Pinheiro, L Filipe C Castro, Eduardo Rocha Peroxisome proliferator-activated receptor gamma (PPARγ) in brown trout: Interference of estrogenic and androgenic inputs in primary hepatocytes. Environ. Toxicol. Pharmacol.: 2016, 46;328-336 PubMed 27541269

Norbert Gleicher, Sarah K Darmon, Vitaly A Kushnir, Andrea Weghofer, Qi Wang, Lin Zhang, David F Albertini, David H Barad How FSH and AMH reflect probabilities of oocyte numbers in poor prognosis patients with small oocyte yields. Endocrine: 2016; PubMed 27510172

Saori Tomita, Mohamed Osama Ali Abdalla, Saori Fujiwara, Tatsuro Yamamoto, Hirotaka Iwase, Mitsuyoshi Nakao, Noriko Saitoh Roles of long noncoding RNAs in chromosome domains. Wiley Interdiscip Rev RNA: 2016; PubMed 27489248


In general, not dealt with as a system in many embryology textbooks, so various chapters: nervous system, head, gastrointestinal tract, reproductive organs, etc. See the online Endocrinology textbook for better descriptions of these tissues.

Endocrinology Textbook - Chapter Titles  
Endocrinology - An Integrated Approach.png
Endocrinology - An Integrated Approach Stephen Nussey and Saffron Whitehead. St. George's Hospital Medical School, London, UK Oxford: BIOS Scientific Publishers; 2001. ISBN-10: 1-85996-252-1

Full Table of Contents

Endocrinology Textbook - Table of Contents  
Endocrinology - An Integrated Approach.png
Endocrinology - An Integrated Approach Stephen Nussey and Saffron Whitehead. St. George's Hospital Medical School, London, UK Oxford: BIOS Scientific Publishers; 2001. ISBN-10: 1-85996-252-1
  1. Principles of endocrinology
    1. Functions of hormones and their regulation
    2. Chemical signalling - endocrine, paracrine, autocrine and intracrine mechanisms
    3. Chemical classification of hormones and their synthesis
    4. Hormone synthesis
    5. Transport of hormones in the circulation and their half-lives
    6. Hormone receptors - cell surface
    7. Hormone receptors - intracellular
    8. Hormones and gene transcription
    9. Hormone receptor regulation
    10. Neuroendocrine interactions
    11. Hormones and the immune system
    12. Hormones, growth promotion and malignancy
    13. Genes, mutations and endocrine function
    14. Clinical evaluation of endocrine disorders
  2. The endocrine pancreas
    1. Glucose turnover
    2. Anabolic and catabolic phases of glucose metabolism
    3. Actions of insulin and glucagon
    4. Lipid metabolism - insulinopenia and diabetic ketosis
    5. Protein metabolism and the anabolic actions of insulin
    6. Definition and diagnosis of diabetes mellitus
    7. Etiology of type 1 DM
    8. Prevention of type 1 DM
    9. Structure, synthesis and metabolism of insulin and glucagon
    10. Anatomical features of pancreatic islets in relation to hormone secretion and its control
    11. Control of insulin and glucagon secretion
    12. Type 2 DM
    13. Causes of DM
    14. Genetic disorders of β-cell function
    15. Counter-regulatory hormones and DM
    16. Complications of DM
    17. Macrovascular circulatory changes
    18. Microvascular changes - diabetic retinopathy, nephropathy and neuropathy
    19. Diabetes and the neuropathic foot
    20. Diabetes and insulin resistance of pregnancy
    21. Development of the pancreas: effects of DM on organogenesis
    22. Treatment of DM - rationale and practical considerations
    23. Hypoglycemia
    24. Physiological responses to hypoglycemia and its treatment
    25. Hypoglycemia and insulinoma
    26. Hypoglycemia in infancy
    27. Disorders of the α, γ and PP cells of the islets
    28. Clinical case questions
  3. The thyroid gland
    1. Iodine intake
    2. Anatomical features of the thyroid gland
    3. Iodine trapping and thyroid function
    4. Synthesis of thyroid hormones
    5. Actions of thyroid hormones
    6. Control of thyroid hormone synthesis and secretion
    7. Hyperthyroidism — Graves' disease
    8. Surgical anatomy and embryology of the thyroid gland
    9. Primary hypothyroidism — Hashimoto's disease and myxedema
    10. Secondary hypothyroidism
    11. Hypothyroidism in infancy and childhood
    12. Thyroid hormone resistance
    13. Non-thyroid illness (‘sick euthyroid’ syndrome)
    14. Transport and metabolism of thyroid hormones
    15. Biochemical measurements of thyroid hormone status
    16. Thyroid growth
    17. Nodular thyroid disease
    18. Thyroid cancer
    19. Clinical case questions
  4. The adrenal gland
    1. Specificity of the biological effects of adrenal steroid hormones
    2. Cholesterol and steroid synthesis in the adrenal cortex
    3. Anatomical and functional zonation in the adrenal cortex
    4. Glucocorticoid receptors
    5. Actions of glucocorticoids and clinical features of Cushing's syndrome
    6. Adrenal cortical androgens
    7. Hypothalamic control of adrenocortical steroid synthesis - CRH and vasopressin
    8. Pituitary control of adrenocortical steroids - ACTH
    9. Feedback control of glucocorticoids
    10. Excess glucocorticoids: biochemical investigation of Cushing's syndrome
    11. Measurements of cortisol in blood, urine and saliva
    12. Dynamic tests of endocrine function
    13. Imaging the adrenal gland
    14. Treatment of Cushing's syndrome
    15. Nelson's syndrome
    16. Excess adrenal androgens - congenital adrenal hyperplasia (CAH)
    17. Deficiency of adrenocortical secretions - Addison's disease
    18. Aldosterone and the control of salt and water balance
    19. Transport and metabolism of adrenocortical steroids
    20. Selective mineralocorticoid excess and deficiency
    21. The adrenal medulla and pheochromocytoma
    22. Catecholamine synthesis and secretion
    23. Diagnosis and treatment of pheochromocytomas
    24. Clinical case questions
  5. The parathyroid glands and vitamin D
    1. Calcium and phosphate in serum and its measurement
    2. Intracellular calcium concentration
    3. Calcium and phosphate balance
    4. Hormonal control of serum Ca2+ and Pi concentrations
    5. Sources, metabolism and transport of vitamin D
    6. Classical actions of vitamin D on intestine and bone
    7. Parathyroid glands and PTH synthesis
    8. Control of PTH secretion
    9. Actions of PTH
    10. Hypercalcemia and primary hyperparathyroidism
    11. Hyperparathyroidism and multiple endocrine neoplasia (MEN)
    12. Hypercalcemia and vitamin D excess
    13. Hypercalcemia and malignancy
    14. Parathyroid hormone-related peptide (PTHrp)
    15. Treatment of hypercalcemia
    16. Mutations of the Ca2+ or PTH receptors
    17. Hypocalcemia and its treatment
    18. Pseudohypoparathyroidism
    19. Vitamin D deficiency
    20. Non-classical actions of vitamin D
    21. Vitamin D resistance and rickets
    22. Hormones and the skeleton
    23. Structure, formation and function of bone
    24. Osteoporosis
    25. Paget's disease (osteitis deformans)
    26. Calcitonin and calcitonin gene-related peptide
    27. Clinical case questions
  6. The gonad
    1. Genetic determination of sexual differentiation
    2. Sexual differentiation of the gonads and internal reproductive tracts
    3. Sexual differentiation of the external genitalia
    4. Control of steroid production in the fetal gonads
    5. Puberty
    6. GnRH and the control of gonadotrophin synthesis and secretion
    7. The gonadotrophins - LH and FSH - and their actions
    8. Endocrine changes in puberty
    9. Precocious sexual development
    10. Delayed puberty
    11. Premature adrenarche
    12. Acne, hair growth and hirsutism
    13. The breast - premature development, hypoplasia and gynecomastia
    14. Testicular function
    15. Control of testicular function
    16. Transport, metabolism and actions of androgens
    17. Spermatogenesis
    18. Erection and ejaculation
    19. Ovarian control and the menstrual cycle
    20. Transport, metabolism and actions of ovarian steroids
    21. The ovary - folliculogenesis and oogenesis
    22. Non-steroidal factors in the control of the hypothalamic-pituitary-gonadal axis
    23. Ovulation, menstruation and its problems
    24. Polycystic ovary syndrome (PCOS)
    25. Contraception
    26. Infertility
    27. Ovulation induction and assisted conception
    28. Ovarian failure, the menopause and andropause
    29. Hormonal replacement therapy (HRT) and selective estrogen receptor modulators (SERMS)
    30. Clinical case questions
  7. The pituitary gland
    1. Anatomical and functional connections of the hypothalamo-pituitary axis
    2. Embryology of the pituitary gland
    3. Craniopharyngioma
    4. Blood supply of the hypothalamo-pituitary axis
    5. Sheehan's syndrome
    6. Growth and somatotrophin deficiency
    7. Growth hormone - secretory patterns and control
    8. Actions of growth hormone and insulin-like growth factors
    9. GH replacement therapy
    10. GH excess - gigantism and acromegaly
    11. Pituitary adenomas - incidence and treatment
    12. Prolactinomas
    13. Prolactin and its control
    14. Circadian rhythms and the suprachiasmatic nucleus
    15. The pineal gland and melatonin
    16. Autonomic functions of the hypothalamus
    17. Obesity
    18. The neural lobe of the pituitary gland - AVP and oxytocin
    19. Clinical case questions
  8. Cardiovascular and renal endocrinology
    1. Endocrinology of heart failure
    2. Paracrine and autocrine regulation of blood pressure: the endocrinology of sepsis
    3. Hormones and blood cell production - erythropoietin
    4. Carcinoid
    5. Clinical case questions
Larsen's Human Embryology - UNSW Students
Larsen's human embryology 5th ed.jpg
Schoenwolf, G.C., Bleyl, S.B., Brauer, P.R., Francis-West, P.H. & Philippa H. (2015). Larsen's human embryology (5th ed.). New York; Edinburgh: Churchill Livingstone. UNSW students have full access to this textbook edition through UNSW Library subscription (with student Zpass log-in).
Endocrine Links: Introduction | BGD Lecture | Science Lecture | Pineal | Hypothalamus‎ | Pituitary | Thyroid | Parathyroid | Thymus‎ | Pancreas‎ | Adrenal‎ | Gonad‎ | Placenta‎ | Other Tissues | Stage 22 | Abnormalities | Hormones | Category:Endocrine
Historic Embryology  
1912 Chromaffin Organs and of the Suprarenal Bodies | 1914 Suprarenal System of Organs


  • Understand the main steps in the development of the thyroid, parathyroid, adrenal, pituitary, pineal glands, thymus and gonads.
  • Have a general understanding of the chief functions of these endocrine organs.
  • Understand the endocrine contribution to embryo development.
  • Understand the endocrine role of the placenta during development.
  • Have a general understanding of different types of hormones and their signaling actions.


Steroid hormone receptor signaling[3]

Hormone Types

Steroid biosynthesis pathway
  • Amino acid derivatives - noradrenaline (norepinepherine), adrenalin (epinepherine) , thyroid hormone
  • Proteins, peptides - thyroid stimulating hormone, leutenising hormone, follicle stimulating hormone
  • Steroids - androgens, glucocorticoids, mineralocorticoids

Hormone Actions

  • Autocrine - acts on self (extracellular fluid)
  • Paracrine - acts locally (extracellular fluid)
  • Endocrine - acts by secretion into blood stream (endocrine organs are richly vascularized)

Hormone Receptors

Hormones are recognised by either cell surface receptors (modified amino acids, peptides, proteins) or cytoplasmic/nuclear receptors (steroids).

Podcast icon.jpg Interested in endocrine and hormone history? Listen to ABC Radio Ockham's Razor 2005-07-31 Centenary of the word "hormone" (File:Audio - centenary of hormone.mp3), by Sydney medical scientist (from SOMS) and writer Dr John Carmody commemorates the centenary of the entry of the word 'hormone' into the English language.

Links: Hormones

Endocrine Origins

  • Derived from epithelia - covering embryo, lining gastrointestinal tract, lining coelomic cavity
  • Also mesenchymal contribution

Development Overview

See specific endocrine organ development.

Pineal Gland

Adult pineal body
Pineal gland position
  • part of epithalmus - neurons, glia and pinealocytes
  • pinealocytes secrete melatonin - cyclic nature of activity, melatonin lowest during daylight
    • inhibit hypothalamic secretion of GnRH until puberty, pineal gland then rapidly regresses.
  • other activities - possibly gamete maturation, antioxidant effect, protect neurons?

Pineal Development

  • Neuroectoderm - prosenecephalon then diencephalon
  • caudal roof, median diverticulum, epiphysis
  • Initially a hollow diverticulum, cell proliferation to solid, pinealocytes (neuroglia), cone-shaped gland innervated by epithalmus

Links: Endocrine - Pineal Development


Hormones - Thyrotrophin releasing hormone (TRH), Corticotrophin releasing hormone (CRH), Arginine vasopressin (AVP), Gonadotrophin releasing hormone (GnRH), Growth hormone releasing hormone (GHRH), Somatostatin, Prolactin relasing factor (PRF), Dopamine

Hypothalamus Development

  • Neuroectoderm - prosenecephalon then diencephalon
  • ventro-lateral wall intermediate zone proliferation
  • Mamillary bodies - form pea-sized swellings ventral wall of hypothalamus

Links: Endocrine - Hypothalamus Development


Adult pituitary

Anterior pituitary hormones - Thyroid-stimulating hormone (TSH), Adrenocorticotrophic hormone (ACTH), Luteinizing hormone (LH), Follicle-stimulating hormone (FSH), Somatotrophin/growth hormone (GH), Prolactin (PRL), Melanocyte-stimulating hormone (MSH)

Posterior pituitary hormones - Oxytocin, Arginine vasopressin

Pituitary Development

Pituitary rabbit development
Pituitary development animation.gif Blue - neural tube ectoderm

Red - surface ectoderm

  • Dual ectoderm origins
    • Ectoderm - ectoderm roof of stomodeum, Rathke's pouch, adenohypophysis
    • Neuroectoderm - prosenecephalon then diencephalon, neurohypophysis


  • Anterior wall proliferates - pars distalis
  • Posterior wall little growth – pars intermedia
  • Rostral growth around infundibular stem – pars tuberalis


  • Infundibulum – median eminence, infundibulum, pars nervosa

Pituitary Timeline

  • Week 4 - hypophysial pouch, Rathke’s pouch, diverticulum from roof
  • Week 5 - elongation, contacts infundibulum, diverticulum of diencephalon
  • Week 6 - connecting stalk between pouch and oral cavity degenerates
  • Week 10 - growth hormone and ACTH detectable
  • Week 16 - adenohypophysis fully differentiated
  • Week 20 to 24 - growth hormone levels peak, then decline

Links: Endocrine - Pituitary Development | Embryo Images - Pituitary


  • Functions from wk10, required for neural development, stimulates metabolism (protein, carbohydrate, lipid), reduced/absence = cretinism (see abnormalities)

Hormones - (amino acid derivatives) Thyroxine (T4), Triiodothyronine (T3)

Thyroid Development

Stage 13 and Stage 22 thyroid development
foramen caecum
  • thyroid median endodermal thickening in the floor of pharynx, outpouch – thyroid diverticulum
  • tongue grows, cells descend in neck
  • thyroglossal duct - proximal end at the foramen cecum of tongue thyroglossal duct
  • thyroid diverticulum - hollow then solid, right and left lobes, central isthmus

Thyroid Timeline

  • 24 days - thyroid median endodermal thickening in the floor of pharynx, outpouch – thyroid diverticulum
  • Week 11 - colloid appearance in thyroid follicles, iodine and thyroid hormone (TH) synthesis

growth factors (insulin-like, epidermal) stimulates follicular growth

Fetal Thyroid Hormone

  • Initial secreted biologically inactivated by modification, late fetal secretion develops brown fat
  • Iodine deficiency- during this period, leads to neurological defects (cretinism)
  • Birth - TSH levels increase, thyroxine (T3) and T4 levels increase to 24 h, then 5-7 days postnatal decline to normal levels

Links: Endocrine - Thyroid Development


Parathyroid adult
  • Parathyroid Hormone - Increase calcium ions [Ca2+], stimulates osteoclasts, increase Ca GIT absorption (opposite effect to calcitonin)
  • Adult Calcium and Phosphate - Daily turnover in human with dietary intake of 1000 mg/day
  • secreted by chief cells

Principal cells cords of cells

Parathyroid Development

Pharyngeal pouches
  • Endoderm - third and fourth pharyngeal pouches, could also have ectoderm and neural crest
    • 3rd Pharyngeal Pouch - inferior parathyroid, initially descends with thymus
    • 4th Pharyngeal Pouch - superior parathyroid
  • Week 6 - diverticulum elongate, hollow then solid, dorsal cell proliferation
  • Fetal parathyroids - respond to calcium levels, fetal calcium levels higher than maternal

Links: Endocrine - Parathyroid Development


  • Thymus - bone-marrow lymphocyte precursors become thymocytes, and subsequently mature into T lymphocytes (T cells)
  • Thymus hormones - thymosins stimulate the development and differentiation of T lymphocytes

Thymus Development

  • Endoderm - third pharyngeal pouch
  • Week 6 - diverticulum elongates, hollow then solid, ventral cell proliferation
  • Thymic primordia - surrounded by neural crest mesenchyme, epithelia/mesenchyme interaction
    • Note in contrast to this historic image (shown here), current research has shown that the human thymic epithelium derives solely from the third pharyngeal pouch (as in the mouse). [4]

Links: Endocrine - Thymus Development


Pancreas adult
pancreas structure
  • Functions - exocrine (amylase, alpha-fetoprotein), 99% by volume; endocrine (pancreatic islets) 1% by volume
  • Exocrine function - begins after birth
  • Endocrine function - from 10 to 15 weeks onward hormone release
    • exact roles of hormones in regulating fetal growth?

Pancreas Development

Pancreatic buds and duct developing
Stage22 pancreas
  • Pancreatic buds - duodenal level endoderm, splanchnic mesoderm forms dorsal and ventral mesentery, dorsal bud (larger, first), ventral bud (smaller, later)
  • Pancreas Endoderm - pancreas may be opposite of liver
    • Heart cells promote/notochord prevents liver formation
    • Notochord may promote pancreas formation
    • Heart may block pancreas formation
  • Duodenum growth/rotation - brings ventral and dorsal buds together, fusion of buds
  • Pancreatic duct - ventral bud duct and distal part of dorsal bud, exocrine function
  • Islet cells - cords of endodermal cells form ducts, from which cells bud off to form islets

Pancreatic Islets

  • Islets of Langerhans - 4 endocrine cell types
  • Alpha - glucagon, mobilizes lipid
  • Beta - insulin, increase glucose uptake
    • Beta cells, stimulate fetal growth, continue to proliferate to postnatal, in infancy most abundant
  • Delta - somatostatin, inhibits glucagon, insulin secretion
  • F-cells - pancreatic polypeptide

Pancreas Timeline

  • Week 7 to 20 - pancreatic hormones secretion increases, small amount maternal insulin
  • Week 10 - glucagon (alpha) differentiate first, somatostatin (delta), insulin (beta) cells differentiate, insulin secretion begins
  • Week 15 - glucagon detectable in fetal plasma

Links: Endocrine - Pancreas Development | Gastrointestinal Tract - Pancreas Development


  • Richly vascularized - arterioles passing through cortex, capillaries from cortex to medulla, portal-like circulation
  • Fetal Cortex - produces a steroid precursor (DEA), converted by placenta into estrogen
  • Adult Medulla - produces adrenalin (epinephrine), noradrenaline (norepinephrine)
  • Fetal adrenal hormones - influence lung maturation

Adrenal cortical hormones - (steroids) Cortisol, Aldosterone, Dehydroepiandrosterone

  • zona glomerulosa - regulated by renin-angiotensin-aldosterone system controlled by the juxtaglomerular apparatus of the kidney.
  • zona fasciculata - regulated by hypothalamo-pituitary axis with the release of CRH and ACTH respectively.

Adrenal medullary hormones - (amino acid derivatives) Epinephrine, Norepinephrine

Adrenal Development

Adrenal medulla.jpg
Week 10 adrenal gland
  • Fetal Adrenals - fetal cortex later replaced by adult cortex
  • Week 6 - fetal cortex, from mesothelium adjacent to dorsal mesentery; Medulla, neural crest cells from adjacent sympathetic ganglia
  • Adult cortex - mesothelium mesenchyme encloses fetal cortex

Adrenal Cortex

  • Late Fetal Period - differentiates to form cortical zones
  • Birth - zona glomerulosa, zona fasiculata present
  • Year 3 - zona reticularis present

Endocrinology - Adrenal Cortex Development

Adrenal Medulla

  • neural crest origin, migrate adjacent to coelomic cavity, initially uncapsulated and not surrounded by fetal cortex, cells have neuron-like morphology
  • 2 cell types - secrete epinepherine (adrenaline) 80%; secrete norepinepherine (noradrenaline* 20%


Links: Endocrine - Adrenal Development


Female HPG axis

HPG Axis - Endocrinology - Simplified diagram of the actions of gonadotrophins

Gonad Development

  • mesoderm - mesothelium and underlying mesenchyme, primordial germ cells
  • Gonadal ridge - mesothelium thickening, medial mesonephros
  • Primordial Germ cells - yolk sac, to mesentery of hindgut, to genital ridge of developing kidney


  • testis-determining factor (TDF) from Y chromosome: presence (testes), absence (ovaries)


  • 8 Weeks, mesenchyme, interstitial cells (of Leydig) secrete testosterone, androstenedione
  • 8 to 12 Weeks - hCG stimulates testosterone production
  • Sustentacular cells - produce anti-mullerian hormone to puberty


  • X chromosome genes regulate ovary development

Corpus Luteum

Corpus luteum histology

A maternal endocrine organ that develops within the ovary in all mammalian species from the ovulating follicle[5]. The key function of this endocrine organ is to maintain pregnancy in response to endocrine signals from the implanting conceptus (chorionic ganadotrophin). Corpus luteum steroidogenesis then alters the normal female reproductive cycle, maintains the endometrial lining of the uterus, and acts on the maternal endocrine system. The corpus luteum, depending upon the species, produces a range of androgens, estrogens and progesterone.

Corpus Luteum Links: anatomy overview | histology overview | low power label | high power label | low power | high power | corpus albicans | theca and granulosa lutein cells | Granulosa cell | Ovary Development | Menstrual Cycle
Links: Endocrine - Gonad Development | Menstrual Cycle | Estrous Cycle


Trophoblast hCG function
  • Human chorionic gonadotrophin (hCG) - like leutenizing hormone, supports corpus luteum in ovary, pregnant state rather than menstrual, maternal urine in some pregnancy testing
  • Human chorionic somatommotropin (hCS) - or placental lactogen stimulate (maternal) mammary development
  • Human chorionic thyrotropin (hCT)
  • Human chorionic corticotropin (hCACTH)
  • progesterone and estrogens - support maternal endometrium
  • Relaxin
  • Placenta - Maternal (decidua) and Fetal (trophoblastic cells, extraembryonic mesoderm) components
  • Endocrine function - maternal and fetal precursors, synthesis and secretion
    • Protein Hormones - chorionic gonadotropin (hCG), chorionic somatomammotropin (hCS) or placental lactogen (hPL), chorionic thyrotropin (hCT), chorionic corticotropin (hCACTH)
      • hCG - up to 20 weeks, fetal adrenal cortex growth and maintenance
      • hCS – rise through pregnancy, stimulates maternal metabolic processes, breast growth
    • Steroid Hormones - progesterone (maintains pregnancy), estrogens (fetal adrenal/placenta)

Links: Endocrine - Placenta Development

Other Endocrine

Endocrine Heart

  • Atrial natriuretic peptide (ANP) - Increase Filtration rate / decrease Na+ reabsorption
  • Endothelins - ET-1, ET-2, ET-3, Vasoconstriction / Increase NO
  • Nitric oxide (NO) - Vasodilatation

Endocrine Kidney

  • Renin - Increase Angiotensin-aldosterone system
  • Prostaglandins - decrease Na+ reabsorption
  • Erythropoietin - Increase Erythrocyte (rbc) production
  • 1,25 (OH)2 vitamin D - calcium homeostasis
  • Prekallikreins - Increase Kinin production

GIT Endocrine

Enteric control of digestive function

  • Gastrin - Secreted from stomach (G cells), role in control of gastric acid secretion
  • Cholecystokinin - small intestine hormone, stimulates secretion of pancreatic enzymes and bile
  • Secretin - small intestine hormone (epithelial cells), stimulates secretion of bicarbonate-rich fluids from pancreas and liver

Adipose Tissue

  • Leptin - polypeptide hormone produced in adipose and many other tissues with also many different roles
  • Adiponectin - regulation of energy homeostasis and glucose and lipid metabolism, as well as acting as an anti-inflammatory on the cellular vascular wall
  • Resistin - (for resistance to insulin, RETN) a 108 amino acid polypeptide and the related resistin-like protein-beta (Resistin-like molecule-beta, RELMbeta) stimulate endogenous glucose production

Links: Endocrine - Other Tissues

Endocrine Functional Changes

  • Puberty - Increased activity
  • Menopause - Decreased activity
  • Disease - (diabetes, thyroid, kidney) suggested trends that genetics, health, nutrition, lifestyle may influence time that these events occur
  • Pharmaceutical impact - birth control, steroids, Hormone Replacement Therapy (HRT)


  1. Petra Dames, Ramona Puff, Michaela Weise, Klaus G Parhofer, Burkhard Göke, Magdalena Götz, Jochen Graw, Jack Favor, Andreas Lechner Relative roles of the different Pax6 domains for pancreatic alpha cell development. BMC Dev. Biol.: 2010, 10;39 PubMed 20377917
  2. Daniel Kelberman, Karine Rizzoti, Robin Lovell-Badge, Iain C A F Robinson, Mehul T Dattani Genetic regulation of pituitary gland development in human and mouse. Endocr. Rev.: 2009, 30(7);790-829 PubMed 19837867 | Endocr Rev.
  3. Alexander Griekspoor, Wilbert Zwart, Jacques Neefjes, Rob Michalides Visualizing the action of steroid hormone receptors in living cells. Nucl Recept Signal: 2007, 5;e003 PubMed 17464358 | PMC1853070 | Nucl Recept Signal.
  4. Alison M Farley, Lucy X Morris, Eric Vroegindeweij, Marianne L G Depreter, Harsh Vaidya, Frances H Stenhouse, Simon R Tomlinson, Richard A Anderson, Tom Cupedo, Jan J Cornelissen, C Clare Blackburn Dynamics of thymus organogenesis and colonization in early human development. Development: 2013, 140(9);2015-26 PubMed 23571219
  5. Alexander Griekspoor, Wilbert Zwart, Jacques Neefjes, Rob Michalides Visualizing the action of steroid hormone receptors in living cells. Nucl Recept Signal: 2007, 5;e003 PubMed 17464358


Endocrine Development This series is devoted to specific areas of fetal, neonatal, pediatric and adolescent endocrinology. It addresses a wide range of relevant issues in the context of a well defined subject and covers new areas of clinical and basic research.


Endocrinology - An Integrated Approach.png Endocrinology - An Integrated Approach Stephen Nussey and Saffron Whitehead, St. George's Hospital Medical School, London, UK Oxford: BIOS Scientific Publishers; 2001.

ISBN-10: 1-85996-252-1 Copyright © 2001, BIOS Scientific Publishers Limited. Bookshelf Link

Endotext.png Endotext De Groot LJ, Beck-Peccoz P, Chrousos G, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. Bookshelf Link


Samim Özen, Şükran Darcan Effects of environmental endocrine disruptors on pubertal development. J Clin Res Pediatr Endocrinol: 2011, 3(1);1-6 PubMed 21448326


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Cite this page: Hill, M.A. (2016) Embryology Endocrine System Development. Retrieved October 21, 2016, from https://embryology.med.unsw.edu.au/embryology/index.php/Endocrine_System_Development

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