Developmental Signals - Slit2/Robo1

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Adult human cardiovascular system

Factor Links: AMH | hCG | BMP | Sonic hedgehog | HOX | FGF | Nanog | NGF | Nodal | Notch | FOX | Hippo | PAX | Retinoic acid | SIX | Slit2/Robo1 | Sox | TBX | TGF-beta | VEGF | WNT | Category:Molecular

Some Recent Findings

Adult human cardiovascular system
  • Alterted SLIT2/ROBO1 signalling is linked to impaired placentation of missed and threatened miscarriage in early pregnancy[1] "Two-thirds of early pregnancy failures present with reduced trophoblast invasion, and SLIT2/ROBO1 signalling is considered to play an important role in trophoblast function during pregnancy. We investigated SLIT2/ROBO1 signalling associated with missed and threatened miscarriage during early gestation. METHODS AND RESULTS: Human placenta samples were collected from women with missed miscarriage (n = 25), threatened miscarriage (n = 22) and termination of pregnancy controls (n = 32). Corresponding decreases in beta human chorionic gonadotrophin (β-hCG) levels and shallow trophoblast invasion were observed in patients with missed and threatened miscarriage, immunohistological staining revealed abnormal Slit2 and Robo1, as well as E-cadherin and activating protein-2 alpha (AP-2α) expression in villi and extravillous trophoblasts, and the expression of these proteins were confirmed in villi and decidua of miscarriage material by Western blotting. Using HTR8/SVneo cells, blocking SLIT2/ROBO1 signalling promoted cell migration, proliferation and suppressed differentiation. Moreover, blocking SLIT2/ROBO1 signalling in HTR8/SVneo cells altered trophoblast differentiation-related and angiogenesis-related gene mRNA expression, which also occurred in the tissues of missed and threatened miscarriage. CONCLUSIONS: SLIT2/ROBO1 signalling may regulate trophoblast differentiation and invasion causing restricting β-hCG production, shallow trophoblast invasion and inhibiting placental angiogenesis in missed and threatened miscarriage during the first trimester."
More recent papers
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Search term: Slit2/Robo1

Shu-Jie Zhao, Yi-Fei Shen, Qing Li, Yun-Jie He, Yun-Kun Zhang, Li-Peng Hu, Yu-Qing Jiang, Nan-Wei Xu, Yu-Ji Wang, Jun Li, Ya-Hui Wang, Fei Liu, Rong Zhang, Guo-Yong Yin, Jin-Hai Tang, Dong Zhou, Zhi-Gang Zhang SLIT2/ROBO1 axis contributes to the Warburg effect in osteosarcoma through activation of SRC/ERK/c-MYC/PFKFB2 pathway. Cell Death Dis: 2018, 9(3);390 PubMed 29523788

Junhui Liu, Weiping Hou, Tao Guan, Luyao Tang, Xufei Zhu, Yi Li, Shihui Hou, Jun Zhang, Hua Chen, Yunjian Huang Slit2/Robo1 signaling is involved in angiogenesis of glomerular endothelial cells exposed to a diabetic-like environment. Angiogenesis: 2018; PubMed 29299781

Xuejing Zhang, Meiyan Mi, Weili Hao, Qiongying Fan, Bulang Gao Progesterone down-regulates SLIT/ROBO expression in mouse corpus luteum. Acta Histochem.: 2017; PubMed 28947260

Ping Li, Yuxun Shi, Hanlin Shuai, Yanzhen Cai, Wenhui Lu, Guang Wang, Lufen Gao, Lijing Wang, Xiujun Fan, Xuesong Yang Alterted SLIT2/ROBO1 signalling is linked to impaired placentation of missed and threatened miscarriage in early pregnancy. Histopathology: 2017; PubMed 28485101

Liqiang Liu, Wenhua Li, Shaomei Geng, Yanwei Fang, Zhimin Sun, Hongchao Hu, Zhaohui Liang, Zhongjie Yan Slit2 and Robo1 expression as biomarkers for assessing prognosis in brain glioma patients. Surg Oncol: 2016, 25(4);405-410 PubMed 27916173

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Cite this page: Hill, M.A. (2018, March 20) Embryology Developmental Signals - Slit2/Robo1. Retrieved from

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© Dr Mark Hill 2018, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
  1. Li P, Shi Y, Shuai H, Cai Y, Lu W, Wang G, Gao L, Wang L, Fan X & Yang X. (2017). Alterted SLIT2/ROBO1 signalling is linked to impaired placentation of missed and threatened miscarriage in early pregnancy. Histopathology , 71, 543-552. PMID: 28485101 DOI.