Y Chromosome: Difference between revisions
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The actual gene targets of SRY are still being determined but at least one downstream gene Sox9 has been identified. Another gene Dax1 (nuclear hormone-receptor superfamily member) when expressed as a transgene will antagonize Sry and also force dosage-sensitive sex reversal. | The actual gene targets of SRY are still being determined but at least one downstream gene Sox9 has been identified. Another gene Dax1 (nuclear hormone-receptor superfamily member) when expressed as a transgene will antagonize Sry and also force dosage-sensitive sex reversal. | ||
==Testis-specific Protein Y Chromosome== | |||
Testis-specific Protein Y Chromosome (TSPY) is an ampliconic gene on the Y chromosome with an unknown function, though the protein that has been shown to interact with gonadoblastoma. A recent study suggests that TSPY serves as a repressor in androgen-induced tumor development in testicular germ-cell tumours (TGCTs). | |||
== References == | == References == |
Revision as of 19:00, 9 November 2010
Introduction
Humans have 23 pairs of chromosomes, 22 autosomes and a pair of sex chromosomes. Males have one X and one Y chromosomes (46, XY) and females have a pair of X chromosomes (46, XX).
- contains approximately 200+ genes
- 50 million base pairs
Some Recent Findings
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Male Sex Determination
Sry gene, found in 1990 on the Y chromosome, the sry gene encodes a "testis-determining factor" a 204aa protein (Mr 23884 Da).
Sry acts as a transcriptional activator (HMG type-high mobility group) binding to DNA and initiating male sex determination then regulating male development. The protein sequence is shown on this current page and the full genebank entry can also be seen. The sry protein has a HMG box that binds DNA by intercalating in the minor groove. Read about the mapping of the testis determining factor which is SRY.
The actual gene targets of SRY are still being determined but at least one downstream gene Sox9 has been identified. Another gene Dax1 (nuclear hormone-receptor superfamily member) when expressed as a transgene will antagonize Sry and also force dosage-sensitive sex reversal.
Testis-specific Protein Y Chromosome
Testis-specific Protein Y Chromosome (TSPY) is an ampliconic gene on the Y chromosome with an unknown function, though the protein that has been shown to interact with gonadoblastoma. A recent study suggests that TSPY serves as a repressor in androgen-induced tumor development in testicular germ-cell tumours (TGCTs).
References
Online Textbooks
- Developmental Biology (6th ed) Gilbert, Scott F. Sunderland (MA): Sinauer Associates, Inc.; c2000. The Digestive Tube and Its Derivatives | Endodermal development of a human embryo
- Search NLM Online Textbooks "Y chromosome" : Developmental Biology | Endocrinology | Molecular Biology of the Cell | The Cell- A molecular Approach
Reviews
<pubmed>18416699</pubmed>
Articles
<pubmed>16284122</pubmed>
Search PubMed
Search November 2010 "Y Chromosome" - All (11590) Review (1052) Free Full Text (2688)
Search Pubmed: Y Chromosome
- Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline
Cite this page: Hill, M.A. (2024, May 19) Embryology Y Chromosome. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Y_Chromosome
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G