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...lay="true">Human_blastocyst_hatching_day_5-6.flv|Human blastocyst hatching movie icon.jpg</wikiflv> [[Media:Human_blastocyst_hatching_day_5-6.mov|Quicktime movie]]

| valign="top" |Movie shows ''in vitro'' development of a human blastocyst between day 5 and day 6 post-fertilization. '''00:03''' - commence blastocyst hatching (1 o'clock position)

{{Movie header}} ...ign="top" |Movie shows ''in vitro'' development of a human {{morula}} to {{blastocyst}} stage occurring between day 3 and day 6 post-fertilization.

| valign="top" |Movie shows ''in vitro'' development of a human blastocyst between day 5 and day 6 post-fertilization. '''00:17''' - commence blastocyst hatching (1 o'clock position)

...jpg|100px|left]] Movie shows ''in vitro'' development of a human morula to blastocyst stage occurring between day 3 and day 6 post-fertilization. Movie shows ''in vitro'' development of a human morula to blastocyst stage occurring between day 3 and day 6 post-fertilization.

{{Movie header}} ...ign="top" |Movie shows ''in vitro'' development of a human {{morula}} to {{blastocyst}} stage occurring between day 5 and day 6 post-fertilization.

===Human Blastocyst (day 3 to 6)=== ...the first week (day 3 and day 6) post-fertilization and finishes with the blastocyst "hatching out" of the protective zone pellucida, ready to begin implantatio

{{Movie header}} ...ign="top" |Movie shows ''in vitro'' development of a human {{morula}} to {{blastocyst}} stage occurring between day 3 and day 6 post-fertilization.

[[Media:Human_blastocyst_day_3-6.mov|Quicktime movie]] | valign="top" |Movie shows ''in vitro'' development of a human morula to blastocyst stage occurring between day 3 and day 6 post-fertilization.

| width=405px|[[File:Human embryo day 5 label2.jpg|400px]] Human blastocyst (day 5) still within zone pellucida.

Stage 4 sees the attached blastocyst begin implantation into the maternal uterine lining epithelium and underlyi * Week 1-2, size 0.1 - 0.2 mm

Human early zygote showing male and female pronuclei The early human {{zygote}} where the male and female {{pronuclei}} (centre of image) have n

...t the formation of a hollow ball of cells, the 1-chambered conceptus or '''blastocyst''' (defined by the presence of this cavity the '''blastocoel'''). == From Oocyte to Blastocyst ==

...ith the animation and additional information such as: a description of the movie, additional images, links, references and copyright information. Note, clic * '''Play''' - Opens just the movie in the browser window, no additional information is shown.

== Week 1 == [[File:Week1 summary.jpg|thumb|Week 1 and 2 development]]

...le:Week1 summary.jpg|thumb|alt=Week 1 and 2 development cartoon|300px|Week 1 and 2 development]] ...Events of Human Development during the first week ([[:Category:Week 1|week 1]]) following fertilization or clinical [[Gestational Age|gestational age]]

==Fertilization and Blastocyst Development== ...first page will give a brief overview of: menstrual cycle, fertilization, blastocyst and implantation. You are not expected to know everything about these proce

...etailed description or for use elsewhere. Look at the [[#Human Development|Human Development]] cartoon below for an overview of the changes seen during the The first videos relate to undergraduate [[Medicine]] phase 1 embryology in BGDA and BGDB.

...g video and genetic analysis of ''in vitro'' human development during week 1 following fertilization. [[File:Model human blastocyst development.jpg|600px]]

[[File:Human embryo day 2.jpg|thumb|300px|Human morula (day 2){{#pmid:19924284|PMID19924284}}]] [[File:Human_embryo_day_3.jpg|thumb|300px|Human morula (day 3){{#pmid:19924284|PMID19924284}}]]

[[Week 1]] | [[Week 2]] | [[Zygote]] | [[Morula]] | [[Blastocyst]] | [[Implantation]] [[File:Week1_summary.jpg|thumb|450px|Week 1 and 2 Development (see [[Week 1 Movie]])]]

| valign="bottom"|{{Ovulation movie}} | valign="bottom"|{{Bovine oocyte movie 1}}

=Week 1 and 2= [[Movie_-_Human_Development_cartoon|Human Development Overview]]

* Understand broadly the events of week 2-3 of human development [http://embryology.med.unsw.edu.au/Movies/week2/week2.mov Movie - Implantation]

...hicken movie 1961.jpg|thumb|150px|link=Historic Chicken Movie 1961|Chicken Movie (1961)]] * Users - 1.4 M

...dure-related risk of miscarriage following CVS was 0.35% (95% CI: -0.31 to 1.00).{{#pmid:29161799|PMID29161799}} A more detailed Cochrane review of {{am ...nic villus sampling, 2.01% for transcervical chorionic villus sampling and 1.18% for amniocentesis. No statistically noticeable differences between the

* Understand broadly the events of week 3 of human development | valign="bottom"|{{Week 3 mesoderm movie}}

#REDIRECT [[Lecture - Week 1 and 2 Development]] =Week 1 and 2=

...imeline graph 02.jpg|thumb|400px|link=One Minute Embryology#Human Timeline|Human development timeline]] ...es on the embryo. These stages are also shown in the movie "Carnegie stage human growth through embryonic period". Identify the key structures in figures on

...rnegieComparisonHRM]] - table of Carnegie stage approx comparison between Human, Rat and Mouse. * [[Template:10wkFetus|10wkFetus]] Human Fetus - female, 10 week, Planes A, B, C and D move towards the midline.

...futures. In the conceptus, this is a period of blastocyst "hatching" rapid blastocyst differentiation into extraembryonic and embryonic tissues and proliferation ...lead to attachment, '''adplantation''', on the inner cell mass side of the blastocyst. This will be the site where '''implantation''' will begin and the placenta

[[File:Early_zygote_labelled.jpg|thumb|300px|Early Human Zygote, with 2 pronuclei]] ...} ({{GA}} week 3) and is described as [[Carnegie stage 1|'''Carnegie stage 1''']]. This stage is followed by mitosis to form 2 blastomeres and then a so

Hatching leaves the blastocyst now free of the zona pellucida and should have occured approximately at the ...lead to attachment, '''adplantation''', on the inner cell mass side of the blastocyst. This will be the site where '''implantation''' will begin and the placenta

...le:Week1 summary.jpg|thumb|alt=Week 1 and 2 development cartoon|300px|Week 1 and 2 development]] Key events of human development during the second week ([[:Category:Week 2|week 2]]) following

...ly as a medical student, but also for our fundamental understanding of the human body. ...tology). This lecture is going to take you briefly through key concepts in human development. I will be using simplified terms in the lecture slides (with d

...es 3,368 - Page edits since Embryology was set up 46,327 - '''Views total 1,882,523''' ...ance Imaging]] page with image of [[Magnetic_Resonance_Imaging#Human_Birth|Human Birth]]. Updated [[Gastrointestinal Tract - Abnormalities]] page with Intes

| valign="bottom"|{{Ovulation movie}} | valign="bottom"|{{Bovine oocyte movie 1}}

[[File:Human_embryo_day_5.jpg|thumb|250px|Human Blastocyst (day 5){{#pmid:19924284|PMID19924284}}]] The blastocyst consists of cells forming an outer '''{{trophectoderm}}''' (TE, {{trophobla

...at the external appearance of embryos in sequence from [[#Carnegie_Stages|1 to 23]]. It is not so important to memorise the dates, as they are only app ...an development during the embryonic period of the first eight weeks (weeks 1 - 8) following fertilization. This period is also considered the organogeni

...is lecture is going to take you briefly through key biological concepts in human development, these will later be explored in more detail through the BGD co [[Media:2019 Foundations Lecture - Introduction to Human Development.pdf|2019 PDF]]

:''From 1 layer of cells to 3 layers that define all tissues of the entire embryo.'' ...tus also forms the fetal component of the placenta, not all cells from our blastocyst will form part of the developing embryo.

==Human Development - Week 1== * Key developmental changes during Week 1 ({{GA}} week 3)

Hatching leaves the blastocyst now free of the zona pellucida and should have occured approximately at the ...lead to attachment, '''adplantation''', on the inner cell mass side of the blastocyst. This will be the site where '''implantation''' will begin and the placenta

...n development timeline graph 02.jpg|thumb|400px|link=One Minute Embryology#Human Timeline]] ...overview of human development. Now in BGDA we will be working through the human development process in more detail, focussing on key events.

[[Special:Statistics|Statistics]] | Content pages - 1,963 Uploaded files - 9,743 Page edits since Embryology was set up - 129,32 ...raft version of historic textbook [[Book_-_Human_Embryology_and_Morphology|Human Embryology and Morphology]] (1902).

| valign="bottom"|{{Birth MRI movie 1}} | valign="bottom"|{{Embryo stage movie 1}}

| Hatching leaves the blastocyst now free of the zona pellucida and should have occured approximately at the ...lead to attachment, '''adplantation''', on the inner cell mass side of the blastocyst. This will be the site where '''implantation''' will begin and the placenta

| Human Embryo - early implantation ([[Carnegie stage 5|stage 5]]) | valign="bottom"|{{Week 2 implant movie}}

...du.au/Medicine/BGDlecture5.htm Lecture 9 Development of the embryo/fetus - 1] (12 May 10-11am, Clancy) ==Week 1==

...ly as a medical student, but also for our fundamental understanding of the human body. This lecture is going to take you briefly through key concepts in human development, these will later be explored in more detail through the BGD co

This is a brief introductory 4 part presentation on the [https://human-embryology.org '''Digital Embryology Consortium'''] ([[Digital Embryology C # [[#1. Human Embryology History|'''Human embryology history''']]

[[Special:Statistics|Statistics]]: Content pages - 1,745 Uploaded files - 8,388 Page edits since Embryology was set up - 113,178 ...ie [[Quicktime Movie - Mouse E15 sectioned microCT|Quicktime version]] | [[Movie - Mouse E15 sectioned microCT|Flash version]].

...that there still exist significant differences between "animal models" and human development. ...ay, "Programmed Cell Death". In development, apoptosis begins in the early blastocyst and is a developmental mechanism found throughout tissues in the embryo and

| This is a brief introductory 4 part presentation on the [https://human-embryology.org '''Digital Embryology Consortium'''] ([[Digital Embryology C # [[#1. Human Embryology History|'''Human embryology history''']]

...f>McDole K. etal., [https://www.cell.com/cell/fulltext/S0092-8674(18)31243-1 In Toto Imaging and Reconstruction of Post-Implantation Mouse Development a ...constructions of key components of the data herein. At the anatomic level, human and mouse kidney development differ in timing, scale, and global features s

#REDIRECT [[BGDA Lecture - Development of the Embryo/Fetus 1]] ...n Development|Lecture]] and [[2010 Foundations Practical - Introduction to Human Development|Practical]].

[[Special:Statistics|Statistics]]: Content pages - 1,351 Uploaded files - ...ovie of simulation for embryonic development from zygote (1 cell stage) to blastocyst (128 cell stage) [[Quicktime_Movie_-_Model_Embryo_to_128_Cell_Stage|Quickti

! About this Movie &nbsp; ...tocyst Day 3-6 Movie]] shows ''in vitro'' development of a human morula to blastocyst stage occurring between day 3 and day 6 post-fertilisation.<ref><pubmed>208

...ould be of value to those wanting a better understanding of the process of human haemochorial placentation. ...the the uterus lining (endometrium epithelium). The hatched [[B#blastocyst|blastocyst]] with a flat outer layer of '''trophoblast cells''' (green), the inner cel

...man fertilization movie 2 frame 03.jpg|thumb|300px|alt=Human fertilization|Human Fertilization]] [[File:Early_zygote_labelled.jpg|thumb|300px|Early Human Zygote]]

...:Stage5_bf11L.jpg|thumb|300px|alt=Image of human conceptus fully implanted|Human conceptus fully implanted ([[Carnegie_stage_5|Stage 5]]).]] ...In humans, this process begins at the end of week 1, with most successful human pregnancies the conceptus implants 8 to 10 days after ovulation, and early

==Week 1 and 2== [[File:Week1 summary.jpg|thumb|Week 1 and 2]]

...acenta a mateno-fetal organ which begins developing at implantation of the blastocyst and is delivered with the fetus at birth. Only recently have we begun to un | valign="bottom"|{{Week 2 implant movie}}

...d in the technique, the risk of a miscarriage related to the test is about 1 %. {{Ultrasound 12wk movie}}

| valign=top|[[File:Stage5 bf11L.jpg|alt=Human embryo Carnegie stage 5|400px]] | valign="top"| '''Facts:''' Week 1 - 2, size 0.1 - 0.2 mm

...follicle can be seen. The final image on this current page is a link to a movie showing follicle development and ovulation. Use the series of images of the ...p3|listen Part 2]] | [[:File:BGD2010-Embryo Lab 120510-302.mp3|download]] (1.7 Mb MP3 14:16)

Development is 1 embryonic cell producing about 100,000,000,000,000 cells in the adult at an ...is]] | [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5500 MCB Movie - The stages of mitosis and cytokinesis in an animal cell]

...bryological tool, the rabbit (Taxon- ''Oryctolagus cuniculus'') along with human was a species which show birth defects with thalidomide (teratogenic effect ...thoracolumbar transitional vertebrae/lumbosacral transitional vertebrae (n=1). These findings suggest that vertebral columns in rabbits display a wide r

...'' and the late '''Prof. I. Tork''' in the early 1980's. The original 27mm Human embryo microfiche images were developed by '''Dr M. Smith '''and the 6mm Pi ...dited with permission of '''Dr B. Freeman''', from his ''Course Manual for Human Embryology ''(1995). Other staff and former staff who had contributed to th

* The Developing Human: Clinically Oriented Embryology (8th Edition) by Keith L. Moore and T.V.N P * Larsen’s Human Embryology - Chapter 1

...one human generation, explaining the extreme phenotypic variation seen in human pedigrees with inherited mtDNA disorders." ...of mitophagy in the setting of HF/HS exposure contributes to the oocyte-to-blastocyst transmission of dysfunctional mitochondria."

...ductive age women. Can result in an increased risk for pre-term birth, HIV-1 acquisition and pelvic inflammatory disease. ...150px|alt=Barr body|link=Molecular_Development_-_X_Inactivation|Barr body (human female neutrophil)]]

[[File:Gray0458.gif|thumb|Historic image of early human vascular development]] * Human Embryology (3rd ed.) Larson Chapter 7 p151-188 Heart, Chapter 8 p189-228 Va

...llowing processes during early human development so far: fertilization and blastocyst development in the first week, implantation in the second week, early place * thought to be generated by a "clock" (1 pair every 90 minutes)

# [[#1._Preimplantation|Preimplantation]] '''Powerpoint Slides:''' [[Media:REI - Reproductive Medicine Seminar 2018.pdf|1 slide/page PDF]] | [[Media:REI - Reproductive Medicine Seminar 2018_3_slide

...llowing processes during early human development so far: fertilization and blastocyst development in the first week, implantation in the second week, early place ...ology.med.unsw.edu.au/pdf/ANAT2341L6Mesoderms1.pdf Mesoderm Lecture 2008 - 1 slide/page ] | [http://embryology.med.unsw.edu.au/pdf/ANAT2341L6Mesoderms4.

...acenta a mateno-fetal organ which begins developing at implantation of the blastocyst and is delivered with the fetus at birth. Only recently have we begun to un * '''Human Embryology''' Larson Ch7 p151-188 Heart, Ch8 p189-228 Vasculature

...acenta a mateno-fetal organ which begins developing at implantation of the blastocyst and is delivered with the fetus at birth. Only recently have we begun to un * '''Human Embryology''' Larson Ch7 p151-188 Heart, Ch8 p189-228 Vasculature

...cessful IVF occurred in 1980.{{#pmid:7353686|PMID7353686}} and during 2005 1,596 IVF babies were born. In the same year in Australia and New Zealand 51, ...rtilized oocyte to become a quality blastocyst, the ploidy of each quality blastocyst is not related to the size of the follicle from which its oocyte was retrie

...is one and a half hour presentation uses your existing knowledge of normal human development in an applied clinical manner in relation to our existing knowl [[File:Human_Carnegie_stage_1-23.jpg|thumb|Human Embryonic Development (week 1 to 8)]]

...diogram.jpg|thumb|150px|alt=idiogram|link=Molecular Development - Genetics|human idiogram]] :(More? [[:File:Human_idiogram.jpg|Human idiogram]] | [[Molecular Development - Genetics]])

[[File:Gray0458.gif|thumb|Historic image of early human vascular development]] * Human Embryology (3rd ed.) Larson Chapter 7 p151-188 Heart, Chapter 8 p189-228 Va

...al embryology and most sciences. The mouse is a useful mammalian model for human embryological development because the mouse: *Has a very similar size genome as the human genome

[[File:Adherens Junction 01.jpg|thumb|150px|link=Blastocyst Development|Adherens junction cadherin]] :(More? [[Blastocyst Development]])

...some ethical issues relating to what parameters will be in future used in blastocyst selection. [[File:Human_idiogram.jpg|thumb|Human idiogram]]

[[File:Human ovulation 01.jpg|thumb|300px|Human ovary undergoing ovulation.{{#pmid:18440526|PMID18440526}}]] The {{menstrual cycle}} describes the female human reproductive cycle. This is a cyclic endocrine regulated change in female a

...nta is a mateno-fetal organ which begins developing at implantation of the blastocyst and is delivered with the fetus at birth. As the fetus relies on the placen ...nflammation. Yet, several factors make comparison of the placenta to other human organs difficult. The placenta comprises tissues from two persons, complica

...a half hour presentation uses your [[Medicine|existing knowledge of normal human development]] in an applied clinical manner in relation to our existing kno * More than 1 in 3 maternal deaths occurred in women who were aged 35 or over.

...he maturing fetal lungs express steroid receptor coactivators 1 and 2 (SRC-1 and SRC-2) that induce production of Surfactant protein-A (SP-A) that is th ...(aRR = 1.92), stillbirth (aRR = 2.12), and intrauterine fetal death (aRR = 1.96). CONCLUSIONS: This population-based study detected a dose-response asso

...liferative to neurogenic divisions. Protein is associated with determining human cerebral cortical size, possibly by maintaining symmetric cleavage plane or ...ng System that monitors Australian data for birth anomalies detected up to 1 year of age. ACAMS superseded the National Congenital Malformations and Bir

...cytokine required for {{blastocyst}} {{implantation}} and also required in human fertility. :(More? {{meiosis}} | {{oocyte}} | {{spermatozoa}} | [[Week 1]] | [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=mboc4&part=A3686 MB

...associated with various genetic syndromes including Neurofibromatosis type 1 and 2. ...d Exner (1846 – 1926) an Austrian physiologist. Also present in a range of human ovarian tumours.

:An acronym for Haplotype Map, an international project to catalogue the human genome single nucleotide polymorphisms (SNPs), the variation in a single DN ...in) An acronym for the placental hormone [[H#human_chorionic_gonadotrophin|human Chorionic Gonadotrophin]].

...ace area of the alveolar sacs. Distal epithelial cells form 2 populations: 1. cells flattens, thins, and spreads to form type I cells; 2. cells remain c ...DNA from the second reductive division (the first was formed from meiosis 1 at ovulation, and the third polar body is from division of this first body)