Integumentary System - Eyelid Development: Difference between revisions
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* '''Molecular biology and genetics of embryonic eyelid development''' | * '''Molecular biology and genetics of embryonic eyelid development'''{{#pmid:26863902|PMID26863902}} "The embryology of the eyelid is a complex process that includes interactions between the surface ectoderm and mesenchymal tissues. In the mouse and human, the eyelids form and fuse before birth; they open prenatally in the human and postnatally in the mouse. In the mouse, cell migration is stimulated by different growth factors such as FGF10, TGF-α, Activin B, and HB-EGF. These growth factors modulate downstream BMP4 signaling, the ERK cascade, and JNK/c-JUN. Several mechanisms, such as the Wnt/β-catenin signaling pathway, may inhibit and regulate eyelid fusion." | ||
* '''Glucocorticoid receptor antagonizes EGFR function to regulate eyelid development''' | |||
* '''Glucocorticoid receptor antagonizes EGFR function to regulate eyelid development'''{{#pmid:21136383|PMID21136383}} "Eyelid formation constitutes a useful model to study epithelial development, as it requires coordinated regulation of keratinocyte proliferation, apoptosis and migration. ...Our data demonstrate that glucocorticoid receptor (GR) deficiency results in delayed and impaired eyelid closure, as illustrated by increased keratinocyte proliferation and apoptosis along with impaired differentiation in GR(-/-) eyelid epithelial cells." | |||
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| [[File:Mark_Hill.jpg|90px|left]] {{Most_Recent_Refs}} | | [[File:Mark_Hill.jpg|90px|left]] {{Most_Recent_Refs}} | ||
Search term: ''Eyelid Embryology'' | Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Eyelid+Embryology ''Eyelid Embryology''] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=Eyelid+Development ''Eyelid Development''] | ||
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* '''HB-EGF promotes epithelial cell migration in eyelid development'''{{#pmid:16141218|PMID16141218}} "Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of growth factors that binds to and activates the EGF receptor (EGFR) and ERBB4. ...These results indicate that soluble HB-EGF secreted from the tip of the leading edge activates the EGFR and ERK pathway, and that synergy with TGFalpha is required for leading edge extension in epithelial sheet migration during eyelid closure." | |||
* '''Eyelid fusion and epithelial differentiation at the ocular surface during mouse embryonic development'''{{#pmid:15944823|PMID15944823}} "Eyelid fusion is a critical period for differentiation of the ocular surface ectoderm into the epithelia of the conjunctiva, cornea, and eyelid skin. The conjunctival epithelium differentiates before the corneal epithelium, which in turn differentiates before the eyelid epidermis." | |||
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==Human Eyelid Timeline== | ==Human Eyelid Timeline== | ||
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| The following data is from a study of human embryonic | | The following data is from a study of human embryonic Carnegie stages.{{#pmid:7364662|PMID7364662}} | ||
* [[Carnegie_stage_10|Stage 10]] optic primordia appear. | * [[Carnegie_stage_10|Stage 10]] optic primordia appear. | ||
* [[Carnegie_stage_13|Stage 13]] - By the end of the fourth week the optic vesicle lies close to the surface ectoderm. The surface ectoderm overlying the optic vesicle, in response to this contact, has thickened to form the lense placode. | * [[Carnegie_stage_13|Stage 13]] - By the end of the fourth week the optic vesicle lies close to the surface ectoderm. The surface ectoderm overlying the optic vesicle, in response to this contact, has thickened to form the lense placode. |
Revision as of 16:57, 8 January 2019
Introduction
Note that some species, such as rodents, are born with closed eyelids.
The palpebral commissure (canthus) is located at the corner of the eye where the upper and lower eyelids meet.
Vision Links: vision | lens | retina | placode | extraocular muscle | cornea | eyelid | lacrima gland | vision abnormalities | Student project 1 | Student project 2 | Category:Vision | sensory | ||
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Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Eyelid Embryology | Eyelid Development |
Older papers |
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These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.
See also the Discussion Page for other references listed by year and References on this current page.
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Human Eyelid Timeline
The following data is from a study of human embryonic Carnegie stages.[5]
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The images below link to virtual slides of the human developing eye at Carnegie stage 22. Click on the image to open or select specific regions from the regions of interest links.
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Virtual Slide - Regions of InterestLinks: Embryo Virtual Slides |
Adult Anatomy
The palpebral commissure (canthus) is located at the corner of the eye where the upper and lower eyelids meet.
Molecular
See recent article on molecular biology and genetics of embryonic eyelid development.[1]
- cell migration - FGF10, TGF-α, Activin B, and HB-EGF modulate downstream BMP4 signaling, the ERK cascade, and JNK/c-JUN.
- Wnt/β-catenin signaling pathway - may inhibit and regulate eyelid fusion.
Abnormalities
Congenital upper eyelid ectopic cilia
References
- ↑ 1.0 1.1 Rubinstein TJ, Weber AC & Traboulsi EI. (2016). Molecular biology and genetics of embryonic eyelid development. Ophthalmic Genet. , 37, 252-9. PMID: 26863902 DOI. Cite error: Invalid
<ref>
tag; name 'PMID26863902' defined multiple times with different content - ↑ Sanchis A, Bayo P, Sevilla LM & Pérez P. (2010). Glucocorticoid receptor antagonizes EGFR function to regulate eyelid development. Int. J. Dev. Biol. , 54, 1473-80. PMID: 21136383 DOI.
- ↑ Mine N, Iwamoto R & Mekada E. (2005). HB-EGF promotes epithelial cell migration in eyelid development. Development , 132, 4317-26. PMID: 16141218 DOI.
- ↑ Zhang H, Hara M, Seki K, Fukuda K & Nishida T. (2005). Eyelid fusion and epithelial differentiation at the ocular surface during mouse embryonic development. Jpn. J. Ophthalmol. , 49, 195-204. PMID: 15944823 DOI.
- ↑ Pearson AA. (1980). The development of the eyelids. Part I. External features. J. Anat. , 130, 33-42. PMID: 7364662
Reviews
<pubmed></pubmed> <pubmed></pubmed> <pubmed>15558481</pubmed> <pubmed>6387662</pubmed>
Articles
<pubmed></pubmed> <pubmed></pubmed> <pubmed>25377219</pubmed> <pubmed>15020428</pubmed> <pubmed>8270467</pubmed> <pubmed>7125235</pubmed>
Search PubMed
Search Pubmed: Eyelid Development
Additional Images
Historic
Gray H. Anatomy of the human body. (1918) Philadelphia: Lea & Febiger.
Glossary Links
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Cite this page: Hill, M.A. (2024, April 26) Embryology Integumentary System - Eyelid Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Integumentary_System_-_Eyelid_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G