File:Chicken embryo E-cad and P-cad gastrulation.png

Localization of E-cad and P-cad mRNA, and E-cad and Slug proteins, in HH stage 4–7 embryos

(A-C, A’-C’) E-cad (CDH1) mRNA expression in HH stage 4, 5 and 7 embryos (A-C) and in transverse sections (A’-C’). (D-F, D’-F’) P-Cad (CDH3) mRNA expression in embryos at stages 4, 5 and 6 (D-F) and in transverse sections (D’-F’). E-cad mRNAs are downregulated in the pre ingression epiblast and in the primitive streak, while P-cad mRNAs persist in the primitive streak and medial mesoderm (arrows). (G-I) Immunofluorescence localization of Slug (green) and cadherin proteins using an antibody that recognizes E-cad and P-cad (red) in transverse sections through the middle streak region of HH stage 4, 5 and 7 embryos.

http://dx.doi.org/10.1371/journal.pone.0153591.g001

Reference

<pubmed>27097030</pubmed>

Moly PK, Cooley JR, Zeltzer SL, Yatskievych TA, Antin PB (2016) Gastrulation EMT Is Independent of P-Cadherin Downregulation. PLoS ONE 11(4): e0153591. doi:10.1371/journal.pone.0153591

Copyright

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