Integumentary System - Eyelid Development
Introduction
Note that some species, such as rodents, are born with closed eyelids.
The palpebral commissure (canthus) is located at the corner of the eye where the upper and lower eyelids meet.
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Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Eyelid Embryology | Eyelid Development |
Older papers |
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These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.
See also the Discussion Page for other references listed by year and References on this current page.
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Human Eyelid Timeline
The following data is from a study of human embryonic Carnegie stages.[5]
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The images below link to virtual slides of the human developing eye at Carnegie stage 22. Click on the image to open or select specific regions from the regions of interest links.
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Virtual Slide - Regions of InterestLinks: Embryo Virtual Slides |
Adult Anatomy
The palpebral commissure (canthus) is located at the corner of the eye where the upper and lower eyelids meet.
Molecular
See recent article on molecular biology and genetics of embryonic eyelid development.[1]
- cell migration - FGF10, TGF-α, Activin B, and HB-EGF modulate downstream BMP4 signaling, the ERK cascade, and JNK/c-JUN.
- Wnt/β-catenin signaling pathway - may inhibit and regulate eyelid fusion.
Abnormalities
Congenital upper eyelid ectopic cilia
References
- ↑ 1.0 1.1 Rubinstein TJ, Weber AC & Traboulsi EI. (2016). Molecular biology and genetics of embryonic eyelid development. Ophthalmic Genet. , 37, 252-9. PMID: 26863902 DOI. Cite error: Invalid
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tag; name 'PMID26863902' defined multiple times with different content - ↑ Sanchis A, Bayo P, Sevilla LM & Pérez P. (2010). Glucocorticoid receptor antagonizes EGFR function to regulate eyelid development. Int. J. Dev. Biol. , 54, 1473-80. PMID: 21136383 DOI.
- ↑ Mine N, Iwamoto R & Mekada E. (2005). HB-EGF promotes epithelial cell migration in eyelid development. Development , 132, 4317-26. PMID: 16141218 DOI.
- ↑ Zhang H, Hara M, Seki K, Fukuda K & Nishida T. (2005). Eyelid fusion and epithelial differentiation at the ocular surface during mouse embryonic development. Jpn. J. Ophthalmol. , 49, 195-204. PMID: 15944823 DOI.
- ↑ Pearson AA. (1980). The development of the eyelids. Part I. External features. J. Anat. , 130, 33-42. PMID: 7364662
Reviews
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Articles
<pubmed></pubmed> <pubmed></pubmed> <pubmed>25377219</pubmed> <pubmed>15020428</pubmed> <pubmed>8270467</pubmed> <pubmed>7125235</pubmed>
Search PubMed
Search Pubmed: Eyelid Development
Additional Images
Historic
Gray H. Anatomy of the human body. (1918) Philadelphia: Lea & Febiger.
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Cite this page: Hill, M.A. (2024, June 23) Embryology Integumentary System - Eyelid Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Integumentary_System_-_Eyelid_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G