BGDA Practical Placenta - Villi Development: Difference between revisions
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==Chorionic Villi== | |||
[[File:Embryo-membranes_stage_11.jpg|thumb|Chorionic villi embryo (Week 4, Stage11)]] | |||
[[File:Stage18_bf10.jpg|thumb|Chorionic villi embryo (Week 7, Stage18)]] | |||
<gallery> | |||
File:Gray0036.gif|Primary chorionic villi | |||
File:Gray0037.gif|Secondary chorionic villi | |||
File:Gray0031.jpg|Tertiary chorionic villi | |||
File:Placenta anchoring villi.jpg|Placenta anchoring villi | |||
File:Placental villi.jpg|Villi first trimester | |||
File:Placental villi 5.jpg|Villi at term | |||
File:Placental_villi_3.jpg|Villi at term | |||
</gallery> | |||
* '''primary villi''' - week 2, first stage of chorionic villi development, trophoblastic shell cells (syncitiotrophoblasts and cytotrophoblasts) form finger-like extensions into maternal decidua. | |||
* '''secondary villi''' - week 3, second stage of chorionic villi development, extraembryonic mesoderm grows into villi, covers entire surface of chorionic sac. | |||
* '''tertiary villi''' third stage of chorionic villi development, mesenchyme differentiates into blood vessels and cells, forms arteriocapillary network, fuse with placental vessels, developing in connecting stalk | |||
* '''stem villi''' - or anchoring villi, cytotrophoblast cells attached to maternal tissue. | |||
* '''branched villi''' - or terminal villi, grow from sides of stem villi, region of main exchange, surrounded by maternal blood in intervillous spaces. | |||
===Chorionoic Villi Location=== | |||
[[File:Gray0034.gif|thumb]] | |||
* originally cover entire chorionic surface and become restricted to decidua basalis region forming 2 regions | |||
* Frondosum - "leafy" where villi are mainly located | |||
* Capsularis - smooth chorion, where villi are absent or not abundant | |||
Revision as of 18:58, 29 May 2012
Practical 14: Implantation and Early Placentation | Villi Development | Maternal Decidua | Cord Development | Placental Functions | Diagnostic Techniques | Abnormalities |
Chorionic Villi
- primary villi - week 2, first stage of chorionic villi development, trophoblastic shell cells (syncitiotrophoblasts and cytotrophoblasts) form finger-like extensions into maternal decidua.
- secondary villi - week 3, second stage of chorionic villi development, extraembryonic mesoderm grows into villi, covers entire surface of chorionic sac.
- tertiary villi third stage of chorionic villi development, mesenchyme differentiates into blood vessels and cells, forms arteriocapillary network, fuse with placental vessels, developing in connecting stalk
- stem villi - or anchoring villi, cytotrophoblast cells attached to maternal tissue.
- branched villi - or terminal villi, grow from sides of stem villi, region of main exchange, surrounded by maternal blood in intervillous spaces.
Chorionoic Villi Location
- originally cover entire chorionic surface and become restricted to decidua basalis region forming 2 regions
- Frondosum - "leafy" where villi are mainly located
- Capsularis - smooth chorion, where villi are absent or not abundant
- Gray0034.gif
Uterus in the third and fourth month
Cytotrophoblast Layer
There is a new interpretation of the changes that are occuring in the cytotrophoblast (CTB) layer during early to full-term human placenta development. Traditionally the interpretation was that the cytotrophoblast layer thinned and became discontinuous towards term. The thinning is thought due to the epithelium surface expanding at a faster rate than its volume. Two recent studies suggest that while the cytotrophoblast layer does indeed thin, it does not become discontinuous.
Syncytiotrophoblast Layer
The syncytiotrophoblast (STB) layer forms the epithelial covering of the entire villous tree. These cells are multinucleated, terminally-differentiated syncytium formed by the fusion of the underlying progenitor cytotrophoblast (CTB) cells. The process is described as "syncytialization" and is mediated by syncytin-1, an envelope protein of a human endogenous retrovirus W (HERV-W). The differentiation is regulated by chorionic gonadotropin (hCG) and the fusion of cytotrophoblast cells is ongoing during placental development.
Cellular parts derived from the syncytiotrophoblasts (apoptotic nuclei and microparticulate debris) can be shed into the maternal blood in which they are bathed. The apototic process appears to be part of the fusion mechanism between cytotrophoblast and the overlying multinucleate syncytiotrophoblast layer.
Studies have suggested that these cells are transcriptionally inactive. A recent study using a number of different detection techniques now suggests that at least some of the cells nuclei may still be transcriptionally inactive.
Mesenchymal Villi
Mesenchymal villi generate all other villous types:
- immature intermediate villi
- stem villi
- mature intermediate villi
- terminal villi
Mesenchymal villi continuously form out of the trophoblastic sprouts throughout pregnancy and have been considered the basis for growth and differentiation of the villous trees.
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Cite this page: Hill, M.A. (2024, June 10) Embryology BGDA Practical Placenta - Villi Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/BGDA_Practical_Placenta_-_Villi_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G