File:TGF-beta signaling pathway.jpg: Difference between revisions
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==Basic overview of TGF-β signalling pathway== | ==Basic overview of TGF-β signalling pathway== | ||
Binding of a ligand to a Type II receptor initiates signaling. The sequestering of a Type I receptor results in the activation of a Receptor-Smad (Smad1/5, Smad2/3). Together with the Co-Smad (Smad4), this complex enters the nucleus and activates the transcription of target genes. The pathway can be inhibited by extracelluar antagonists, or intracellularly via Inhibitor-Smad (Smad6/7) or the ubiquitin ligase SMURF. | # Binding of a ligand to a Type II receptor initiates signaling. | ||
# The sequestering of a Type I receptor results in the activation of a Receptor-Smad (Smad1/5, Smad2/3). | |||
# Together with the Co-Smad (Smad4), this complex enters the nucleus and activates the transcription of target genes. | |||
The pathway can be inhibited by extracelluar antagonists, or intracellularly via Inhibitor-Smad (Smad6/7) or the ubiquitin ligase SMURF. | |||
:{{Template:Factor Links}} | |||
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© 2011 Pang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | © 2011 Pang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | ||
[[Category:TGF-beta]] | |||
[[Category:Molecular]] [[Category:Cartoon]] | [[Category:Molecular]] [[Category:Cartoon]] | ||
Latest revision as of 17:59, 10 September 2011
Basic overview of TGF-β signalling pathway
- Binding of a ligand to a Type II receptor initiates signaling.
- The sequestering of a Type I receptor results in the activation of a Receptor-Smad (Smad1/5, Smad2/3).
- Together with the Co-Smad (Smad4), this complex enters the nucleus and activates the transcription of target genes.
The pathway can be inhibited by extracelluar antagonists, or intracellularly via Inhibitor-Smad (Smad6/7) or the ubiquitin ligase SMURF.
| Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Original file name: Figure 1. Journal.pone.0024152.g001.jpg dpi:10.1371/journal.pone.0024152.g001
Reference
Pang K, Ryan JF, Baxevanis AD, Martindale MQ (2011) Evolution of the TGF-β Signaling Pathway and Its Potential Role in the Ctenophore, Mnemiopsis leidyi. PLoS ONE 6(9): e24152. PLoS ONE
© 2011 Pang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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| current | 15:11, 10 September 2011 |  | 600 × 559 (47 KB) | S8600021 (talk | contribs) | ==Basic overview of TGF-β signalling pathway== Binding of a ligand to a Type II receptor initiates signaling. The sequestering of a Type I receptor results in the activation of a Receptor-Smad (Smad1/5, Smad2/3). Together with the Co-Smad (Smad4), this |
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