Gastrointestinal Tract - Gall Bladder Development: Difference between revisions

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:{{Template:Gastrointestinal Tract Links}} | [[Gastrointestinal Tract - Gall Bladder Histology|Gall Bladder Histology]] | [http://embryology.med.unsw.edu.au/Notes/git7a.htm original page]
{{Gastrointestinal Tract Links}} | [[Gastrointestinal Tract - Gall Bladder Histology|Gall Bladder Histology]] | [http://embryology.med.unsw.edu.au/Notes/git7a.htm original page]


== Some Recent Findings ==
== Some Recent Findings ==
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* '''Embryology of the biliary tract'''<ref name="PMID20551648"><pubmed>20551648</pubmed></ref> "A hepatic diverticulum appears in the ventral wall of the primitive midgut early in the 4th week of intrauterine life in the development of the human embryo. This small diverticulum is the anlage for the development of the liver, extrahepatic biliary ducts, gallbladder, and ventral pancreas. By the 5th week, all elements of the biliary tree are recognizable. Marked elongation of the common duct occurs with plugging of the lumen by epithelial cells. Recanalization of the lumen of the common duct starts at the end of the 5th week and moves slowly distally. By the 6th week, the common duct and ventral pancreatic bud rotate 180 degrees clockwise around the duodenum. Early in the 7th week, the bile and pancreatic ducts end in closed cavities of the duodenum. Between the early 8th and 12th week, hepatopancreatic ducts have both superior and inferior orifices."
* '''Embryology of the biliary tract'''<ref name="PMID20551648"><pubmed>20551648</pubmed></ref> "A hepatic diverticulum appears in the ventral wall of the primitive midgut early in the 4th week of intrauterine life in the development of the human embryo. This small diverticulum is the anlage for the development of the liver, extrahepatic biliary ducts, gallbladder, and ventral pancreas. By the 5th week, all elements of the biliary tree are recognizable. Marked elongation of the common duct occurs with plugging of the lumen by epithelial cells. Recanalization of the lumen of the common duct starts at the end of the 5th week and moves slowly distally. By the 6th week, the common duct and ventral pancreatic bud rotate 180 degrees clockwise around the duodenum. Early in the 7th week, the bile and pancreatic ducts end in closed cavities of the duodenum. Between the early 8th and 12th week, hepatopancreatic ducts have both superior and inferior orifices."
* '''Muscularis mucosae versus muscularis propria in gallbladder, cystic duct, and common bile duct: smoothelin and desmin immunohistochemical study'''<ref name="PMID21074688"><pubmed>21074688</pubmed></ref> "The muscle layer in the cystic duct and common bile duct is not well defined, and it is unresolved whether it represents muscularis mucosae or muscularis propria. ... Based on our findings, we conclude that, in the gallbladder wall, the muscle layer is muscularis propria and there is no muscularis mucosae present. In the cystic duct and common bile duct, only an attenuated and incomplete muscle layer of muscularis mucosae is present; because there is no muscularis propria, there probably is limited contractile function."
* '''Muscularis mucosae versus muscularis propria in gallbladder, cystic duct, and common bile duct: smoothelin and desmin immunohistochemical study'''<ref name="PMID21074688"><pubmed>21074688</pubmed></ref> "The muscle layer in the cystic duct and common bile duct is not well defined, and it is unresolved whether it represents muscularis mucosae or muscularis propria. ... Based on our findings, we conclude that, in the gallbladder wall, the muscle layer is muscularis propria and there is no muscularis mucosae present. In the cystic duct and common bile duct, only an attenuated and incomplete muscle layer of muscularis mucosae is present; because there is no muscularis propria, there probably is limited contractile function."
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Search term: ''Gall Bladder Embryology''


PMID: 21074688
<pubmed limit=5>Gall Bladder Embryology</pubmed>
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Revision as of 23:18, 5 Mayıs 2013

Introduction

Early embryonic gall bladder (Carnegie stage 13, Week 4)

This section of notes gives an overview of Gall Bladder and hillary tree development, histology and abnormalities associated with the biliary system. In the adult, the gall bladder is a site of bile salt storage and concentration, to then be released into the duodenum where they act to solubilize dietary lipids by their detergent effect. Bile salts are a cholesterol derivative (breakdown product).

The transverse septum differentiates to form the hepatic diverticulum and the hepatic primordium, these two structures together will go on to form different components of the mature liver and gall bladder.

The hepatic diverticulum divides into two parts: pars hepatica (larger cranial part, primordium of the liver) and pars cystica (smaller ventral invagination, primordium of gall bladder).

The pars cystica vacuolates and expands, the stalk becoming the cystic duct. This structure is initially hollow, then solid (by proliferation of epithelial lining), and then recanalized occurs by vacuolation of this expanded epithelium. There are several opinions as to whether the duct has a solid phase or remains patent throughout development.[1][2]

See also Gall Bladder Histology.


GIT Links: Introduction | Medicine Lecture | Science Lecture | endoderm | mouth | oesophagus | stomach | liver | gallbladder | Pancreas | intestine | mesentery | tongue | taste | enteric nervous system | Stage 13 | Stage 22 | gastrointestinal abnormalities | Movies | Postnatal | milk | tooth | salivary gland | BGD Lecture | BGD Practical | GIT Terms | Category:Gastrointestinal Tract
GIT Histology Links: Upper GIT | Salivary Gland | Smooth Muscle Histology | Liver | Gallbladder | Pancreas | Colon | Histology Stains | Histology | GIT Development
Historic Embryology - Gastrointestinal Tract  
1878 Alimentary Canal | 1882 The Organs of the Inner Germ-Layer The Alimentary Tube with its Appended Organs | 1884 Great omentum and transverse mesocolon | 1902 Meckel's diverticulum | 1902 The Organs of Digestion | 1903 Submaxillary Gland | 1906 Liver | 1907 Development of the Digestive System | 1907 Atlas | 1907 23 Somite Embryo | 1908 Liver | 1908 Liver and Vascular | 1910 Mucous membrane Oesophagus to Small Intestine | 1910 Large intestine and Vermiform process | 1911-13 Intestine and Peritoneum - Part 1 | Part 2 | Part 3 | Part 5 | Part 6 | 1912 Digestive Tract | 1912 Stomach | 1914 Digestive Tract | 1914 Intestines | 1914 Rectum | 1915 Pharynx | 1915 Intestinal Rotation | 1917 Entodermal Canal | 1918 Anatomy | 1921 Alimentary Tube | 1932 Gall Bladder | 1939 Alimentary Canal Looping | 1940 Duodenum anomalies | 2008 Liver | 2016 GIT Notes | Historic Disclaimer
Human Embryo: 1908 13-14 Somite Embryo | 1921 Liver Suspensory Ligament | 1926 22 Somite Embryo | 1907 23 Somite Embryo | 1937 25 Somite Embryo | 1914 27 Somite Embryo | 1914 Week 7 Embryo
Animal Development: 1913 Chicken | 1951 Frog

| Gall Bladder Histology | original page

Some Recent Findings

  • Embryology of the biliary tract[2] "A hepatic diverticulum appears in the ventral wall of the primitive midgut early in the 4th week of intrauterine life in the development of the human embryo. This small diverticulum is the anlage for the development of the liver, extrahepatic biliary ducts, gallbladder, and ventral pancreas. By the 5th week, all elements of the biliary tree are recognizable. Marked elongation of the common duct occurs with plugging of the lumen by epithelial cells. Recanalization of the lumen of the common duct starts at the end of the 5th week and moves slowly distally. By the 6th week, the common duct and ventral pancreatic bud rotate 180 degrees clockwise around the duodenum. Early in the 7th week, the bile and pancreatic ducts end in closed cavities of the duodenum. Between the early 8th and 12th week, hepatopancreatic ducts have both superior and inferior orifices."
  • Muscularis mucosae versus muscularis propria in gallbladder, cystic duct, and common bile duct: smoothelin and desmin immunohistochemical study[3] "The muscle layer in the cystic duct and common bile duct is not well defined, and it is unresolved whether it represents muscularis mucosae or muscularis propria. ... Based on our findings, we conclude that, in the gallbladder wall, the muscle layer is muscularis propria and there is no muscularis mucosae present. In the cystic duct and common bile duct, only an attenuated and incomplete muscle layer of muscularis mucosae is present; because there is no muscularis propria, there probably is limited contractile function."

Embryonic Development

Stage 13 image 076.jpg

Stage 13 image 077.jpg

Early embryonic gall bladder (Carnegie stage 13, Week 4)


Stage 22 image 084.jpg

Late embryonic gall bladder (Carnegie stage 22, Week 8)

Abnormalities

Infections

These mainly relate to postnatal infections. Recent studies in the mouse have identified that gastrointestinal tract listeria infections can relocate to the gall bladder and reside there, leading to later reinfection of the gastrointestinal tract.


Links: Bacterial Infection

Additional Images

See also Gall Bladder Histology

  • Historic drawing gall bladder anatomy

    Historic drawing gall bladder anatomy

  • Historic drawing gall bladder transverse section

    Historic drawing gall bladder transverse section

  • Abnormality - ectopic opening of the common bile duct (CBD) into the duodenal bulb.

    Abnormality - ectopic opening of the common bile duct (CBD) into the duodenal bulb.

References

  1. ↑ <pubmed>12360416</pubmed>
  2. ↑ 2.0 2.1 <pubmed>20551648</pubmed>
  3. ↑ <pubmed>21074688</pubmed>


Reviews

<pubmed>21074731</pubmed> <pubmed>20152372</pubmed> <pubmed>18484608</pubmed> <pubmed>15853977</pubmed> <pubmed>15382016</pubmed>

Articles

<pubmed>21078254</pubmed> <pubmed>20191134</pubmed> <pubmed>16273658</pubmed>

Search Pubmed

July 2010

Search Bookshelf Gall Bladder Development

Search Pubmed Now: Gall Bladder Development | Cholangiocyte Development |


More Reviews and Articles


Glossary Links

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Cite this page: Hill, M.A. (2026, September 14) Embryology Gastrointestinal Tract - Gall Bladder Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Gastrointestinal_Tract_-_Gall_Bladder_Development

What Links Here?
© Dr Mark Hill 2026, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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