Neural Crest - Enteric Nervous System
|Embryology - 15 Dec 2018 Expand to Translate|
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- 1 Introduction
- 2 Some Recent Findings
- 3 Plexuses
- 4 Development Overview
- 5 Mouse Model
- 6 Chicken Model
- 7 Historic
- 8 Neural Crest Migration
- 9 Molecular
- 10 Abnormalities
- 11 References
- 12 Additional Images
- 13 External Links
- 14 Glossary Links
The enteric nervous system (ENS) regulates many key aspects of the gastrointestinal tract including: motility, secretion and blood flow. In the body region, neural crest cells form the entire enteric nervous system, both neurons and glia, of the gastrointestinal tract.
The neural crest are bilaterally paired strips of cells arising in the ectoderm at the margins of the neural tube. These cells migrate to many different locations and differentiate into many cell types within the embryo. This means that many different systems (neural, skin, tooth, head, face, heart, adrenal glands, gastrointestinal tract) will also have a contribution fron the neural crest cells.
Vagal neural crest cells initially migrate into the foregut splanchnic mesoderm of the developing gastrointestinal tract, these cells then migrate caudally along the gut into the midgut. A second population of sacral neural crest cells have been identified as migrating into the region of the hindgut.
The two gastrointestinal plexuses are located between the longitudinal and circular smooth muscle layers (myenteric plexus, Auerbach's plexus) and in the submucosal layer (submucosal plexus, Meissner's plexus). Interstitial cells of Cajal (ICCs) within the myenteric plexus are pacemaker cells that control peristaltic contraction waves.
intestine | Gastrointestinal Tract Development
Some Recent Findings
|More recent papers|
This table shows an automated computer PubMed search using the listed sub-heading term.
References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.
Guillaume Chapelet, Laurène Leclair-Visonneau, Thomas Clairembault, Michel Neunlist, Pascal Derkinderen Can the gut be the missing piece in uncovering PD pathogenesis? Parkinsonism Relat. Disord.: 2018; PubMed 30448099
Hui Hu, Yuanyuan Ding, Wenbo Mu, Ying Li, Yanpeng Wang, Weifang Jiang, Yong Fu, Jinfa Tou, Wei Chen DRG-Derived Neural Progenitors Differentiate into Functional Enteric Neurons Following Transplantation in the Postnatal Colon. Cell Transplant: 2018;963689718811061 PubMed 30442032
Subhash Kulkarni, Julia Ganz, James Bayrer, Laren Becker, Milena Bogunovic, Meenakshi Rao Advances in Enteric Neurobiology: The "Brain" in the Gut in Health and Disease. J. Neurosci.: 2018, 38(44);9346-9354 PubMed 30381426
Arnaud Bessac, Patrice D Cani, Etienne Meunier, Gilles Dietrich, Claude Knauf Inflammation and Gut-Brain Axis During Type 2 Diabetes: Focus on the Crosstalk Between Intestinal Immune Cells and Enteric Nervous System. Front Neurosci: 2018, 12;725 PubMed 30364179
| These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.
|Myenteric plexus||Submucosal plexus|
|Auerbach's plexus||Meissner's plexus|
|Leopold Auerbach (1828–1897) a German anatomist and neuropathologist.||Georg Meissner (1829–1905) a German anatomist and physiologist.|
|Links: enteric nervous system | intestine | neural crest | PMID 25428846|
- week 7 - rostro-caudal neural crest cell colonization of the gut complete and differentiated into neurons and glia. Interstitial cells of Cajal (ICCs) localized in the ganglion plexus.
- foregut neurons and glia were aggregated into ganglion plexus (myenteric region) not in submucosa.
- hind gut neurons and glia are dispersed within the mesenchyme.
- week 9 - myenteric plexus, longitudinal and circular muscle layers formed along the entire gut.
- week 12 - scattered and individual neurons and glia, and small ganglion plexuses were detected in the foregut and midgut submucosa. Muscularis mucosae formed at the foregut and midgut.
- week 14 - ganglion plexus seen in the hind gut submucosa. Muscularis mucosae formed at the hindgut.
- week 20 - ICCs preferentially localized at the periphery of the plexus.
Mouse enteric plexus GFP
In the chicken gut, neural crest cells from both vagal (somite level 1-7) and sacral (somite level 28 and posterior) levels differentiate into the neurons and glial cells of the enteric nervous system.
See also Nicole Le Douarin's research.
(myenteric plexus) In 1864 Auerbach first described the neural plexus lying between the longitudinal and circular smooth muscle layers of the gastrointestinal tract. The plexus has both parasympathetic and sympathetic input and is involved in the rhythmic peristaltic contractions of the gut wall. Plexus named after Leopold Auerbach (1828 – 1897) a German anatomist and neuropathologist born in Breslau.
(submucosal plexus) Part of the enteric nervous system lying in the submucosa layer of the gastrointestinal tract is associated with mucosal secretion (secretomotor). Embryologically derived from neural crest cells. Named after Georg Meissner (1829-1905) a German histologist, physiologist and anatomist.
Neural Crest Migration
- Impdh2 - Inosine 5′ monophosphate dehydrogenase
(intestinal aganglionosis, Hirschsprung's disease, aganglionic colon, megacolon, congenital aganglionic megacolon, congenital megacolon) A condition caused by the lack of enteric nervous system (neural ganglia) in the intestinal tract responsible for gastric motility (peristalsis). In general, its severity is dependent upon the amount of the GIT that lacks intrinsic ganglia, due to developmental lack of neural crest migration into those segments. (More? Neural Crest System - Abnormalities)
Historically, Hirschsprung's disease takes its name from Dr Harald Hirschsprung (1830-1916) a Danish pediatrician (of German extraction). In 1886, he presented at the German Society of Pediatrics conference in Berlin a case of 2 infants who died of complications of bowel obstruction (H. Hirschsprung, Stuhltragheit Neugeborener in Folge von Dilatation und Hypertrophie des Colons, Jhrb f Kinderh 27 (1888), pp. 1-7). Later autopsies identified a dilatation and hypertrophy of large intestine, and the rectum appeared normally narrow. Hirschsprung suggested that the condition was an inborn disease and named it congenital megacolon.
The first indication in newborns is an absence of the first bowel movement, other symptoms include throwing up and intestinal infections. Clinically this is detected by one or more tests (barium enema and x ray, manometry or biopsy) and can currently only be treated by surgery. A temoporary ostomy (Colostomy or Ileostomy) with a stoma is carried out prior to a more permanent pull-through surgery.
|Ostomy - Aganglionic portion removed||Stoma - intestine attached to the abdomen wall|
|Short section of the colon without smooth muscle neural ganglia||Aganglionic segment removed||Reattachment|
Hirschsprung’s disease (1.3 per 10,000 births) ICD-10 Q43.1
- A condition characterised by partial or complete bowel obstruction resulting from absence of peristalsis in a segment of bowel due to an aganglionic section of the bowel.
- More than two-thirds (66.7%) of the babies born with this anomaly were males.
- Women aged 40 years or older had the highest rate of affected pregnancies.
- Bondurand N, Dufour S & Pingault V. (2018). News from the endothelin-3/EDNRB signaling pathway: Role during enteric nervous system development and involvement in neural crest-associated disorders. Dev. Biol. , , . PMID: 30171849 DOI.
- Nagy N, Barad C, Hotta R, Bhave S, Arciero E, Dora D & Goldstein AM. (2018). Collagen 18 and agrin are secreted by enteric neural crest cells to remodel their microenvironment and regulate their migration during ENS development. Development , , . PMID: 29678817 DOI.
- Radenkovic G, Radenkovic D & Velickov A. (2018). Development of interstitial cells of Cajal in the human digestive tract as the result of reciprocal induction of mesenchymal and neural crest cells. J. Cell. Mol. Med. , 22, 778-785. PMID: 29193736 DOI.
- Uribe RA, Hong SS & Bronner ME. (2018). Retinoic acid temporally orchestrates colonization of the gut by vagal neural crest cells. Dev. Biol. , 433, 17-32. PMID: 29108781 DOI.
- Green SA, Uy BR & Bronner ME. (2017). Ancient evolutionary origin of vertebrate enteric neurons from trunk-derived neural crest. Nature , 544, 88-91. PMID: 28321127 DOI.
- Faure S, McKey J, Sagnol S & de Santa Barbara P. (2015). Enteric neural crest cells regulate vertebrate stomach patterning and differentiation. Development , 142, 331-42. PMID: 25519241 DOI.
- Jin S, Martinelli DC, Zheng X, Tessier-Lavigne M & Fan CM. (2015). Gas1 is a receptor for sonic hedgehog to repel enteric axons. Proc. Natl. Acad. Sci. U.S.A. , 112, E73-80. PMID: 25535338 DOI.
- Goldstein AM, Hofstra RM & Burns AJ. (2013). Building a brain in the gut: development of the enteric nervous system. Clin. Genet. , 83, 307-16. PMID: 23167617 DOI.
- Fu M, Tam PK, Sham MH & Lui VC. (2004). Embryonic development of the ganglion plexuses and the concentric layer structure of human gut: a topographical study. Anat. Embryol. , 208, 33-41. PMID: 14991401 DOI.
- Fujimura T, Shibata S, Shimojima N, Morikawa Y, Okano H & Kuroda T. (2016). Fluorescence Visualization of the Enteric Nervous Network in a Chemically Induced Aganglionosis Model. PLoS ONE , 11, e0150579. PMID: 26943905 DOI.
- Erickson CA & Goins TL. (2000). Sacral neural crest cell migration to the gut is dependent upon the migratory environment and not cell-autonomous migratory properties. Dev. Biol. , 219, 79-97. PMID: 10677257 DOI.
- Abeywardana S & Sullivan EA 2008. Congenital Anomalies in Australia 2002-2003. Birth anomalies series no. 3 Cat. no. PER 41. Sydney: AIHW National Perinatal Statistics Unit.
Hao MM, Bornstein JC, Vanden Berghe P, Lomax AE, Young HM & Foong JP. (2013). The emergence of neural activity and its role in the development of the enteric nervous system. Dev. Biol. , 382, 365-74. PMID: 23261929 DOI.
Musser MA & Michelle Southard-Smith E. (2013). Balancing on the crest - Evidence for disruption of the enteric ganglia via inappropriate lineage segregation and consequences for gastrointestinal function. Dev. Biol. , 382, 356-64. PMID: 23376538 DOI.
Hao MM, Boesmans W, Van den Abbeel V, Jennings EA, Bornstein JC, Young HM & Vanden Berghe P. (2011). Early emergence of neural activity in the developing mouse enteric nervous system. J. Neurosci. , 31, 15352-61. PMID: 22031881 DOI.
Burns AJ & Douarin NM. (1998). The sacral neural crest contributes neurons and glia to the post-umbilical gut: spatiotemporal analysis of the development of the enteric nervous system. Development , 125, 4335-47. PMID: 9753687
Anderson RB, Newgreen DF, Young HM. Neural Crest and the Development of the Enteric Nervous System. In: Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience; 2000-. Available from: http://www.ncbi.nlm.nih.gov/books/NBK6273/
Search All Databases: Enteric Neural Development
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Cite this page: Hill, M.A. (2018, December 15) Embryology Neural Crest - Enteric Nervous System. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Neural_Crest_-_Enteric_Nervous_System
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