Neural - Prosencephalon Development

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Introduction

Stage10 sem6.jpg

Neural development is one of the earliest systems to begin and the last to be completed after birth. This development generates the most complex structure within the embryo and the long time period of development means in utero insult during pregnancy may have consequences to development of the nervous system.

The early central nervous system begins as a simple neural plate that folds to form a groove then tube, open initially at each end. Failure of these opening to close contributes a major class of neural abnormalities (neural tube defects).

Within the neural tube stem cells generate the 2 major classes of cells that make the majority of the nervous system : neurons and glia. Both these classes of cells differentiate into many different types generated with highly specialized functions and shapes. This section covers the establishment of neural populations, the inductive influences of surrounding tissues and the sequential generation of neurons establishing the layered structure seen in the brain and spinal cord.

  • Neural development beginnings quite early, therefore also look at notes covering Week 3- neural tube and Week 4-early nervous system.
  • Development of the neural crest and sensory systems (hearing/vision/smell) are only introduced in these notes and are covered in other notes sections.


Neural Links: ectoderm | neural | neural crest | ventricular | sensory | Stage 22 | gliogenesis | neural fetal | Medicine Lecture - Neural | Lecture - Ectoderm | Lecture - Neural Crest | Lab - Early Neural | neural abnormalities | folic acid | iodine deficiency | Fetal Alcohol Syndrome | Postnatal | Postnatal - Neural Examination | Histology | Historic Neural | Category:Neural
Neural Parts: neural | prosencephalon | telencephalon cerebrum | amygdala | hippocampus | basal ganglia | lateral ventricles | diencephalon | Epithalamus | thalamus | hypothalamus‎ | pituitary | pineal | third ventricle | mesencephalon | tectum | cerebral aqueduct | rhombencephalon | metencephalon | pons | cerebellum | myelencephalon | medulla oblongata | spinal cord | neural vascular | meninges | Category:Neural

Some Recent Findings

Developing mouse forebrain Robo3 expression[1]
  • Development of laminar organization of the fetal cerebrum[2] "Heads of 131 fetal specimens of 14-40 weeks gestational age (GA) were scanned by 3.0T MRI. Eleven fetal specimens of 14-27 weeks GA were scanned by 7.0T MRI. On T(1)-weighted 3.0T MRI, layers could be visualized at 14 weeks GA and appeared clearer after 18 weeks GA. On 7.0T MRI, four zones could be recognized at 14 weeks GA. During 15-22 weeks GA, when laminar organization appeared typical, seven layers including the periventricular zone and external capsule fibers could be differentiated, which corresponded to seven zones in histological stained sections. At 23-28 weeks GA, laminar organization appeared less typical, and borderlines among them appeared obscured. After 30 weeks GA, it disappeared and turned into mature-like structures. The developing lamination appeared the most distinguishable at the parieto-occipital part of brain and peripheral regions of the hippocampus. The migrating thalamocortical afferents were probably delineated as a high signal layer located at the lower, middle, and upper part of the subplate zone at 16-28 weeks GA on T(1)-weighted 3.0T MRI."
More recent papers
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Search term: Prosencephalon Embryology

<pubmed limit=5>Prosencephalon Embryology</pubmed>

Development Overview

Neuralation begins at the trilaminar embryo with formation of the notochord and somites, both of which underly the ectoderm and do not contribute to the nervous system, but are involved with patterning its initial formation. The central portion of the ectoderm then forms the neural plate that folds to form the neural tube, that will eventually form the entire central nervous system.

Early developmental sequence: Epiblast - Ectoderm - Neural Plate - Neural groove and Neural Crest - Neural Tube and Neural Crest


Neural Tube Development
Neural Tube Primary Vesicles Secondary Vesicles Adult Structures
week 3 week 4 week 5 adult
neural plate
neural groove
neural tube

Brain
prosencephalon telencephalon Rhinencephalon, Amygdala, Hippocampus, Cerebrum (Cortex), Hypothalamus, Pituitary | Basal Ganglia, lateral ventricles
Diencephalon Epithalamus, Thalamus, Subthalamus, Pineal, third ventricle
mesencephalon mesencephalon Tectum, Cerebral peduncle, Pretectum, cerebral aqueduct
rhombencephalon metencephalon pons, cerebellum
myelencephalon medulla oblongata
spinal cord

Primary Vesicles

Brain primary vesicle development (Carnegie stage 13)

CNS primary vesicles.jpg


Additional Images

Historic

Human Embryology And Morphology (1921)
Keith, A. Human Embryology And Morphology (1921) Longmans, Green & Co.:New York.

9 Fore-Brain and 10 Fore-Brain Cerebral Vesicles

References

  1. <pubmed>19366869</pubmed>| Cereb Cortex.
  2. <pubmed>20981415</pubmed>

Reviews

<pubmed>19560042</pubmed> <pubmed>17275286</pubmed> <pubmed>17030124</pubmed> <pubmed>16418000</pubmed> <pubmed>12626695</pubmed> <pubmed>12461551</pubmed>

Articles

<pubmed>11955708</pubmed> <pubmed>11803577</pubmed> <pubmed>11734354</pubmed> <pubmed>10473296</pubmed> <pubmed>10375509</pubmed> <pubmed>9810564</pubmed> <pubmed>1661870</pubmed> <pubmed>4018406</pubmed>

Search PubMed

Search Pubmed: Prosencephalon Embryology | Prosencephalon Development |


Glossary Links

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Cite this page: Hill, M.A. (2019, August 22) Embryology Neural - Prosencephalon Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Neural_-_Prosencephalon_Development

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© Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G