Neural - Medulla Oblongata Development
|Embryology - 13 Apr 2021 Expand to Translate|
|Google Translate - select your language from the list shown below (this will open a new external page)|
العربية | català | 中文 | 中國傳統的 | français | Deutsche | עִברִית | हिंदी | bahasa Indonesia | italiano | 日本語 | 한국어 | မြန်မာ | Pilipino | Polskie | português | ਪੰਜਾਬੀ ਦੇ | Română | русский | Español | Swahili | Svensk | ไทย | Türkçe | اردو | ייִדיש | Tiếng Việt These external translations are automated and may not be accurate. (More? About Translations)
The medulla or medulla oblongata develops from the secondary brain vesicle the myelencephalon, that in turn formed from the earlier primary brain vesicle rhombencephalon. The neural tube lateral walls have 2 halves (alar and a basal lamina) and are connected by a floor plate and roof-plate region.
Neural development is one of the earliest systems to begin and the last to be completed after birth. This development generates the most complex structure within the embryo and the long time period of development means in utero insult during pregnancy may have consequences to development of the nervous system.
The early central nervous system begins as a simple neural plate that folds to form a groove then tube, open initially at each end. Failure of these opening to close contributes a major class of neural abnormalities (neural tube defects).
Within the neural tube stem cells generate the 2 major classes of cells that make the majority of the nervous system : neurons and glia. Both these classes of cells differentiate into many different types generated with highly specialized functions and shapes. This section covers the establishment of neural populations, the inductive influences of surrounding tissues and the sequential generation of neurons establishing the layered structure seen in the brain and spinal cord. Neural development beginnings quite early, therefore also look at notes covering Week 3 neural tube and Week 4 early nervous system.
|Historic Medulla Embryology|
Sabin FR. and Knower H. An atlas of the medulla and midbrain, a laboratory manual (1901) Baltimore: Friedenwald.
Essick CR. The development of the nuclei pontis and the nucleus arcuatus in man. (1912) Amer. J Anat. 13(1): -54.
Some Recent Findings
|More recent papers|
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
Search term: Medulla Oblongata Embryology
<pubmed limit=5>Medulla Oblongata Embryology</pubmed>
Neuralation begins at the trilaminar embryo with formation of the notochord and somites, both of which underly the ectoderm and do not contribute to the nervous system, but are involved with patterning its initial formation. The central portion of the ectoderm then forms the neural plate that folds to form the neural tube, that will eventually form the entire central nervous system.
- Early developmental sequence: Epiblast - Ectoderm - Neural Plate - Neural groove and Neural Crest - Neural Tube and Neural Crest
|Neural Tube||Primary Vesicles||Secondary Vesicles||Adult Structures|
|week 3||week 4||week 5||adult|
|prosencephalon (forebrain)||telencephalon||Rhinencephalon, Amygdala, hippocampus, cerebrum (cortex), hypothalamus, pituitary | Basal Ganglia, lateral ventricles|
|diencephalon||epithalamus, thalamus, Subthalamus, pineal, posterior commissure, pretectum, third ventricle|
|mesencephalon (midbrain)||mesencephalon||tectum, Cerebral peduncle, cerebral aqueduct, pons|
|myelencephalon||medulla oblongata, isthmus|
|spinal cord, pyramidal decussation, central canal|
Early Brain Vesicles
Historic Ziegler Model
- Links: Ziegler Models
- Watson C, Bartholomaeus C & Puelles L. (2019). Time for Radical Changes in Brain Stem Nomenclature-Applying the Lessons From Developmental Gene Patterns. Front Neuroanat , 13, 10. PMID: 30809133 DOI.
- Jin PP, Xia F, Ma BF, Li Z, Zhang GF, Deng YC, Tu ZL, Zhang XX & Hou SX. (2019). Spatiotemporal expression of NDRG2 in the human fetal brain. Ann. Anat. , 221, 148-155. PMID: 30312765 DOI.
- García-Moreno F, Pedraza M, Di Giovannantonio LG, Di Salvio M, López-Mascaraque L, Simeone A & De Carlos JA. (2010). A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei. Nat. Neurosci. , 13, 680-9. PMID: 20495559 DOI.
Duncan JR, Paterson DS & Kinney HC. (2008). The development of nicotinic receptors in the human medulla oblongata: inter-relationship with the serotonergic system. Auton Neurosci , 144, 61-75. PMID: 18986852 DOI.
Lorke DE, Kwong WH, Chan WY & Yew DT. (2003). Development of catecholaminergic neurons in the human medulla oblongata. Life Sci. , 73, 1315-31. PMID: 12850246
Tan K & Le Douarin NM. (1991). Development of the nuclei and cell migration in the medulla oblongata. Application of the quail-chick chimera system. Anat. Embryol. , 183, 321-43. PMID: 1867385
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2021, April 13) Embryology Neural - Medulla Oblongata Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Neural_-_Medulla_Oblongata_Development
- © Dr Mark Hill 2021, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G