Lecture - Stem Cells

From Embryology

Introduction

Week 1 human development
Blastocyst development

Embryology is all about stem cells, a single cell (zygote) divides and differentiates to form all the tissues throughout the body. Furthermore within some tissues, stem cells remain to continuously replace cells that are lost through the life of that tissue. In recent years scientific and general interest in this topic has increased due to the many issues that surround this specialised cell type. This lecture will introduce the various types/sources of stem cells as well as their practical and therapeutic potentials. A brief discussion of the pros and cons of different types of stem cells currently investigated in the field of medical research will be discussed.



Here are the slides for today's lecture ANAT2341 Beverdam 2017 - Stem cell biology and technology.



Objectives

  • Tissue development and regeneration Stem cell biology
  • Stem cell niches
  • Stem cell regulation
  • Stem cells and cancer Regenerative medicine
  • Stem cell sources
  • Future of regenerative medicine

Additional Lecture Resources

References  
UNSW Embryology logo
Hill, M.A. (2017). UNSW Embryology (17th ed.) Retrieved November 23, 2017, from https://embryology.med.unsw.edu.au
Stem Cell Links: Introduction | Timeline | Placental Cord Blood | Adult | Induced | Yamanaka Factors | Somatic Cell Nuclear Transfer | Ethics | Category:Stem Cell

Archive: 2016 PDF | 2015 PDF | 2014 PDF

The Nobel Prize in Physiology or Medicine 2012 Awarded jointly to Sir John B. Gurdon and Shinya Yamanaka "for the discovery that mature cells can be reprogrammed to become pluripotent"
  • Yamanaka Factors Are a set of 4 transcription factors when introduced into cells induces stem cell formation. PMID 16904174 | PMID 18035408 | PMID 20535199
  • John Gurdon used nuclear transplantation and cloning to show that the nucleus of a differentiated somatic cell retains the totipotency necessary to form a whole organism.

Stem Cells - Induced

Stem Cell Therapies Opportunities for Ensuring the Quality and Safety of Clinical Offerings: Summary of a Joint Workshop.

Board on Health Sciences Policy; Board on Life Sciences; Division on Earth and Life Studies; Institute of Medicine; National Academy of Sciences. Washington (DC): National Academies Press (US); 2014 Jun 18. http://www.ncbi.nlm.nih.gov/books/NBK223197

NIH Report NIH - Regenerative Medicine 2006


 2017 ANAT2341 - Timetable | Course Outline | Group Projects | Moodle | Tutorial 1 | Tutorial 2 | Tutorial 3

Labs: 1 Fertility and IVF | 2 ES Cells to Genome Editing | 3 Preimplantation and Early Implantation | 4 Reproductive Technology Revolution | 5 Cardiac and Vascular Development | 6 CRISPR-Cas9 | 7 Somitogenesis and Vertebral Malformation | 8 Organogenesis | 9 Genetic Disorders | 10 Melanocytes | 11 Stem Cells | 12 Group

Lectures: 1 Introduction | 2 Fertilization | 3 Week 1/2 | 4 Week 3 | 5 Ectoderm | 6 Placenta | 7 Mesoderm | 8 Endoderm | 9 Research Technology | 10 Cardiovascular | 11 Respiratory | 12 Neural crest | 13 Head | 14 Musculoskeletal | 15 Limb | 16 Renal | 17 Genital | 18 Endocrine | 19 Sensory | 20 Fetal | 21 Integumentary | 22 Birth | 23 Stem cells | 24 Revision

 Student Projects: 1 Cortex | 2 Kidney | 3 Heart | 4 Eye | 5 Lung | 6 Cerebellum