|Embryology - 26 Feb 2017 Expand to Translate|
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- 1 Introduction
- 2 Some Recent Findings
- 3 Early Mouse Development MicroCT
- 4 Human Embryo
- 5 Human Placenta
- 6 Newborn
- 7 Adult
- 8 Movies
- 9 Optical Coherence Tomography
- 10 Radiation Exposure
- 11 References
- 12 External Links
- 13 Glossary Links
In embryology, the technique of micro-CT (μCT) has recently begun to become relevant in animal models and used for analysis of normal development features and those seen in genetically modified animal models, such as the mouse (More? Mouse Development).
Computed Tomography or computed axial tomography (CAT or CT scan) began in 1970's using x-ray and a computer to produce images either as individual slices or reconstructed to give three dimensional (3D) views of specific anatomical regions or structures.
Other potential developmental research imaging techniques include: positron emission tomography (PET), single photon emission computed tomography, magnetic resonance imaging, computed tomography, optical bioluminescence, fluorescence and high frequency ultrasound.
- Links: Movies - Computed Tomography | Abnormal Development - Radiation | Category:Computed Tomography
Some Recent Findings
|More recent papers|
This table shows an automated computer PubMed search using the listed sub-heading term.
References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.
Judd Fastenberg, Michel Nassar First Branchial Cleft Cyst. N. Engl. J. Med.: 2016, 375(16);e33 PubMed 27797306
Hidenori Tsukui, Koji Koinuma, Mitsuaki Morimoto, Hisanaga Horie, Alan Kawarai Lefor, Yuka Kagaya, Haruo Takahashi, Tomonori Yano, Daisuke Matsubara, Hironori Yamamoto, Naohiro Sata Crohn's disease presenting as a ceco-urachal fistula. Clin J Gastroenterol: 2017, 10(1);32-36 PubMed 27766543
Kateřina Vymazalová, Lenka Vargová, Tomáš Zikmund, Jozef Kaiser The possibilities of studying human embryos and foetuses using micro-CT: a technical note. Anat Sci Int: 2016; PubMed 27730490
Fang Tong, Yue Liang, Muhammad Fasahat Khan, Lin Zhang, Wenhe Li, Mohammed Mahmoodurrahman, Yiwu Zhou A fatal case of severe neck abscess due to a third branchial cleft fistula: morphologic and immunohistochemical analyses. Diagn Pathol: 2016, 11(1);87 PubMed 27628180
Inés Moreno-Jiménez, Gry Hulsart-Billstrom, Stuart A Lanham, Agnieszka A Janeczek, Nasia Kontouli, Janos M Kanczler, Nicholas D Evans, Richard Oc Oreffo The chorioallantoic membrane (CAM) assay for the study of human bone regeneration: a refinement animal model for tissue engineering. Sci Rep: 2016, 6;32168 PubMed 27577960
Early Mouse Development MicroCT
|Stage 17 Embryo|
|Page | Play|
Right image shows computed tomography angiography (CTA) of the term human placenta viewed from the fetal side.
- CA - chorionic artery
- PSA - primary stem artery
- SSA - secondary stem artery
- TSA - tertiary stem artery
- Links: Skull Development
Renal Vascular Anomalies: Multiple renal arteries | Accessory renal artery | Supernumerary right renal vein 1 | Supernumerary right renal vein 1 | Multiple right renal veins 2 | Multiple right renal veins 2 | Cardiovascular System Development
Absent Cervical Spine Pedicle (volume render CT)
|a arrow||b arrow||c arrow|
|Lateral view VRTshows the dorsally displaced right articular pillar of C5.||Abnormal enlarged right intervertebral foramen of C4-5. which is a consequence of the absent cervical pedicle is displayed on an oblique view VRT image.||Spina bifida occulta at the same level as well as a reversed facet-joint on the right (arrowhead in c) are well depicted on a dorsal view VRT images (c).|
- Links: Movies - Computed Tomography
Optical Coherence Tomography
Optical Coherence Tomography (OCT) is a non-invasive imaging technique generating high resolution (axial resolution 5–7 μm) cross-sectional images. The techniques has been used clinically for diagnosis and management in:
- ophthalmology (spectral-domain OCT) for retinal diseases.
- dermatology for evaluation of skin lesions, skin changes, parasitic infestations.
Computed tomography is a source of medical X-ray radiation exposure to the general population. The risk to an individual patient on the basis of dose levels of developing a malignant tumour due to CT is low and acceptable compared to the substantial benefit. There is though a large range/variation in radiation exposure between individual institutions and equipment settings.
Total radiology collective effective dose
- UK (2005-2006) approximately 60% from CT.
- Germany (2000-2005) for cancer patients from all X-ray procedures was approximately 82%.
- USA about 67%
- Eric J Schmidt, Trish E Parsons, Heather A Jamniczky, Julian Gitelman, Cvett Trpkov, Julia C Boughner, C Cairine Logan, Christoph W Sensen, Benedikt Hallgrímsson Micro-computed tomography-based phenotypic approaches in embryology: procedural artifacts on assessments of embryonic craniofacial growth and development. BMC Dev. Biol.: 2010, 10;18 PubMed 20163731 | BMC Developmental Biology
- Karl Degenhardt, Alexander C Wright, Debra Horng, Arun Padmanabhan, Jonathan A Epstein Rapid 3D phenotyping of cardiovascular development in mouse embryos by micro-CT with iodine staining. Circ Cardiovasc Imaging: 2010, 3(3);314-22 PubMed 20190279
- John T Johnson, Mark S Hansen, Isabel Wu, Lindsey J Healy, Christopher R Johnson, Greg M Jones, Mario R Capecchi, Charles Keller Virtual histology of transgenic mouse embryos for high-throughput phenotyping. PLoS Genet.: 2006, 2(4);e61 PubMed 16683035 | PLoS Genetics
- Anne S Rasmussen, Henrik Lauridsen, Christoffer Laustsen, Bjarke G Jensen, Steen F Pedersen, Lars Uhrenholt, Lene W T Boel, Niels Uldbjerg, Tobias Wang, Michael Pedersen High-resolution ex vivo magnetic resonance angiography: a feasibility study on biological and medical tissues. BMC Physiol.: 2010, 10;3 PubMed 20226038 | BMC Physiol.
- Sheo Kumar, Zafar Neyaz, Archna Gupta The utility of 64 channel multidetector CT angiography for evaluating the renal vascular anatomy and possible variations: a pictorial essay. Korean J Radiol: 2009, 11(3);346-54 PubMed 20461189 | PMC2864862 | Korean J Radiol
- Roman Guggenberger, Gustav Andreisek, Hans Scheffel, Simon Wildermuth, Sebastian Leschka, Paul Stolzmann Absent cervical spine pedicle and associated congenital spinal abnormalities - a diagnostic trap in a setting of acute trauma: case report. BMC Med Imaging: 2010, 10;25 PubMed 21062465 | BMC Med Imaging.
- Yoshito Tsushima, Ayako Taketomi-Takahashi, Hiroyuki Takei, Hidenori Otake, Keigo Endo Radiation exposure from CT examinations in Japan. BMC Med Imaging: 2010, 10;24 PubMed 21044293 | BMC Med Imaging.
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
- University of Calgary 3D Morphometrics Lab
- Duke Center for In Vivo Microscopy A 4D Atlas and Morphologic Database
- Normal C57BL/6 mouse embryos from embryonic day E10.5 to E19.5
- Normal C57BL/6 mouse neonates from post-natal day 0 to 32
- Mutant mouse embryos with cardiac septation defects (conditional ablation of the Smoothened receptor gene, Mef2C-AHF-Cre;Smoflox/- mutants)
- Drishti and Drishti-2 stands for vision or insight in Sanskrit, an Indian language. Ajay Limaye
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Cite this page: Hill, M.A. 2017 Embryology Computed Tomography. Retrieved February 26, 2017, from https://embryology.med.unsw.edu.au/embryology/index.php/Computed_Tomography
- © Dr Mark Hill 2017, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G