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Cleft lip and cleft palate are birth defects that occur during the first trimester of pregnancy in which the fetus' lip or mouth fails to develop properly. As the development of the palate and lips occur separately in the developing fetus, it is possible for the baby to have both of these defects. Patients suffering from cleft lip or palate usually have difficulty speaking, eating, hearing, and are susceptible to ear infections <ref> 21331089</ref>. Although causes of cleft lip and palate are still being investigated, a notable aetiological factor includes the widely used drug, methotrexate. Several investigations have been undertaken to understand the mechanism of action of methotrexate in order to take preventative measures. | Cleft lip and cleft palate are birth defects that occur during the first trimester of pregnancy in which the fetus' lip or mouth fails to develop properly. As the development of the palate and lips occur separately in the developing fetus, it is possible for the baby to have both of these defects. Patients suffering from cleft lip or palate usually have difficulty speaking, eating, hearing, and are susceptible to ear infections <ref> 21331089</ref>. Although causes of cleft lip and palate are still being investigated, a notable aetiological factor includes the widely used drug, methotrexate. Several investigations have been undertaken to understand the mechanism of action of methotrexate in order to take preventative measures. | ||
Methotrexate is commonly used to treat rheumatoid arthritis, cancer (breast and leukaemia), and has also been used to terminate ectopic pregnancies. Research has revealed severe teratogenic effects of methotrexate causing structural defects during pregnancy particularly involving the central nervous system, skeletal structures including the palate, and the heart <ref>Natekar, P. (2007). Methotrexate Induced Gross Malformations in Chick Embryos. Journal Of Human Ecology, 21(3), 223-226. Retrieved from http://www.krepublishers.com/02-Journals/JHE/JHE-21-0-000-000-2007-Web/JHE-21-3-000-000-2007-Abstract-PDF/JHE-21-3-223-226-2007-1577-Natekar-P-E/JHE-21-3-223-226-2007-1577-Natekar-P-E-Tt.pdf</ref>. | Methotrexate is commonly used to treat rheumatoid arthritis, cancer (breast and leukaemia), and has also been used to terminate ectopic pregnancies. Research has revealed severe teratogenic effects of methotrexate causing structural defects during pregnancy particularly involving the central nervous system, skeletal structures including the palate, and the heart <ref>Natekar, P. (2007). Methotrexate Induced Gross Malformations in Chick Embryos. Journal Of Human Ecology, 21(3), 223-226. Retrieved from http://www.krepublishers.com/02-Journals/JHE/JHE-21-0-000-000-2007-Web/JHE-21-3-000-000-2007-Abstract-PDF/JHE-21-3-223-226-2007-1577-Natekar-P-E/JHE-21-3-223-226-2007-1577-Natekar-P-E-Tt.pdf</ref>. Its mechanism of action involves decreasing the proliferation rate of the cytotrophoblast cells of the trophoblast layer of the embryo, and acts as an antifolate <ref>22434686</ref>. | ||
Revision as of 17:39, 10 September 2015
Lab Attendance
Lab 1 --Z3462297 (talk) 13:47, 7 August 2015 (AEST)
Lab 2 --Z3462297 (talk) 13:19, 14 August 2015 (AEST)
Lab 3 --Z3462297 (talk) 12:26, 21 August 2015 (AEST)
Lab 4 --Z3462297 (talk) 12:13, 28 August 2015 (AEST)
Lab 5 --Z3462297 (talk) 12:06, 4 September 2015 (AEST)
Lab Assessment 1
1. <pubmed>25830275</pubmed>
Over time, massage therapy has been widely used to treat physical pain and mental difficulties and currently causes no significant adverse effects or risks to the patient. The purpose of this study was to investigate the impact of deep relaxation therapy (andullation) using oscillating vibrations on blastocyst transfer in in vitro fertilisation (IVF) cryo-cycles. The 267 IVF patients that participated in this study collectively had a mean age of 36.3 years and all previously received a transfer of vitrified, warmed blastocysts. Before embryo transfer, the test group received a deep relaxation massage for 30 minutes on a vibrating device, in comparison to the control group that underwent no changes. The main measurable factors included pregnancy rates using a urine test for hCG, ongoing pregnancies by examining the fetal heartbeat and birth rates, and miscarriage rates.
The results showed that patients who received andullation therapy before embryo transfer, had significantly greater pregnancy rates, ongoing pregnancies and birth rates compared to those who did not, regardless of age and hormonal status.
- Pregnancy rates: test group 58.9%, control group 41.7%
- Ongoing pregnancies: test group 53.6%, control group 33.2%
- Birth rates: test group 32%, control group 20.3%
The research team concluded that andullation therapy preceding to blastocyst transfer in cryo-cycles greatly improve implantation, as it reduces stress, uterine contractions and may also enhance blood flow in the abdomen. Ultimately, these findings have showed that massage therapy is a suitable method to enhance assisted-reproduction techniques (ARTs).
2. <pubmed>26054135</pubmed>
Acupuncture and moxibustion are key natural therapies that play a role in traditional Chinese medicine, and have been a recommended treatment for various conditions. The aim of the investigate was to observe the effects of acupuncture and moxibustion on pregnancy in IVF-embryo transfer (IVF-ET) patients, and to determine its application value in IVF-ET treatment. 114 IVF-ET patients that were treated with standard long-term program at luteal phase were equally and randomly divided into a test and control group. The test group underwent one session of acupuncture and moxibustion treatment before embryo-transfer, thus a total of 3 sessions of the therapy were undertaken. The control group did not receive acupuncture or moxibustion prior to ET. Measurable factors of this experiment included: "endometrial morphology and blood flow, levels of estrogen, progesterone and luteinizing hormone when hCG was injected, gonadotropin dosage, number of oocytes, high-quality embryo number, embryo cultivation rate and pregnancy rates" (Chen and Hau, 2015).
Patients treated with acupuncture and moxibustion revealed significantly higher estrogen levels on the day of hCG injections and high-quality embryo rate. It was also noted that endometrial blood flow and morphology was affected such that endometrial receptivity was increased. Therefore with further analysis into application and specific impacts, the researcher suggests acupuncture and moxibustion will improve IVF-ET outcome in patients and be a key assistant therapeutic.
--Mark Hill (talk) 11:15, 4 September 2015 (AEST) Good summaries of these 2 research papers. (5/5)
Lab Assessment 2
Uploading Images in 5 Easy Steps | ||
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First Read the help page Images and Copyright Tutorial.
Students cannot delete images once uploaded. You will need to email me with the full image name and request deletion, that I am happy to do with no penalty if done before I assess. Non-Table version of this page
|
Embryos during late blastula phase and early gastrulation[1]
PMID 25887993
--Mark Hill (talk) 11:19, 4 September 2015 (AEST) Image uploaded correctly with reference, copyright and student template. The file name is long (File:Embryos during late blastula phase and early gastrulation.jpg) and should have included the species to be a better description, e.g. File:Midas cichlid late blastula and early gastrula.jpg. (4/5)
Lab Assessment 3
The following are research articles discussing possible treatments for male infertility
1. <pubmed>22958644</pubmed> This article investigates the use of clomiphene citrate, hCG and human menopausal gonadotropin (hMG), to treat oligospermia as they increase hormones that are essential for successful spermatogenesis to occur, including FSH and testosterone.
2. <pubmed>26097523</pubmed>
The research discussed in this article discusses the advantages of using cerium dioxide nanoparticles (CNPs) to treat male infertility due to its antioxidant effects. The research team experimented on male rats to observe CNP effects on male health and infertility as oxidative stress plays a key role in preventing proper spermatogenesis.
3. <pubmed>PMC4023371</pubmed>
Research article also focuses on the effects of oxidative stress on male fertility. It discusses the use of lycopenes as a possible treatment for infertility disorders due to its antioxidant properties, as well as contributing to gap junction communication, modulation of gene expression, regulation of the cell cycle and immunological aspects.
--Mark Hill (talk) 11:19, 4 September 2015 (AEST) These 3 papers relate to the group project and you have given a good brief description. (5/5)
Lab Assessment 4
Mesoderm Development
ANAT2341 Student 2015 Quiz Questions
Lab 5 Assessment
Cleft Lip and cleft palate are associated with many different environmental and genetic causes. Identify and describe one cause of these abnormalities.
Cleft lip and cleft palate are birth defects that occur during the first trimester of pregnancy in which the fetus' lip or mouth fails to develop properly. As the development of the palate and lips occur separately in the developing fetus, it is possible for the baby to have both of these defects. Patients suffering from cleft lip or palate usually have difficulty speaking, eating, hearing, and are susceptible to ear infections [2]. Although causes of cleft lip and palate are still being investigated, a notable aetiological factor includes the widely used drug, methotrexate. Several investigations have been undertaken to understand the mechanism of action of methotrexate in order to take preventative measures.
Methotrexate is commonly used to treat rheumatoid arthritis, cancer (breast and leukaemia), and has also been used to terminate ectopic pregnancies. Research has revealed severe teratogenic effects of methotrexate causing structural defects during pregnancy particularly involving the central nervous system, skeletal structures including the palate, and the heart [3]. Its mechanism of action involves decreasing the proliferation rate of the cytotrophoblast cells of the trophoblast layer of the embryo, and acts as an antifolate [4].
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References
- ↑ <pubmed>25887993</pubmed>
- ↑ 21331089
- ↑ Natekar, P. (2007). Methotrexate Induced Gross Malformations in Chick Embryos. Journal Of Human Ecology, 21(3), 223-226. Retrieved from http://www.krepublishers.com/02-Journals/JHE/JHE-21-0-000-000-2007-Web/JHE-21-3-000-000-2007-Abstract-PDF/JHE-21-3-223-226-2007-1577-Natekar-P-E/JHE-21-3-223-226-2007-1577-Natekar-P-E-Tt.pdf
- ↑ 22434686