2017 Group Project 1
2017 Student Projects | |||
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Cerebral Cortex
Mark Hill (talk) 15:59, 14 September 2017 (AEST) Feedback
- lots of sub-headings, but no actual text.
- no defined structure to the sequence of sub-headings.
- no research images related to what is an extensively researched topic.
- historic background of key research findings, put our understanding today in perspective.
- Lon list of abnormalities, with no description.
Introduction
( Susannah )
What is it?
For concept: https://www.youtube.com/watch?v=dNngOlsLuGI
You might find this helpful (although you need to request copyright permission):
"Difference Between Cerebrum and Cerebral Cortex." DifferenceBetween.Com. August 7, 2012. < http://www.differencebetween.com/difference-between-cerebrum-and-vs-cerebral-cortex/ >
Histology of Cerebral Cortex
https://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0024757/ Z5177691 (talk) 22:37, 23 August 2017 (AEST)
Early Development of the Brain (and Nervous System)
( Eden )
For concept:
https://www.youtube.com/watch?v=XdN9i_ZWGho
https://embryology.med.unsw.edu.au/embryology/index.php/Neural_-_Cerebrum_Development
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989000/ https://embryology.med.unsw.edu.au/embryology/index.php/Neural_System_Development
Development of Cerebral Cortex
( Anna )
Terminology
- Corticogenesis:
- Zones:
- Ventricular zone
- Subventricular zone
- Cortical Plate
- Preplate: neural progenitor cells split into 2 regions
- Marginal zone:
- Subplate:
Timeline
Nature article: https://www.nature.com/nrn/journal/v9/n2/full/nrn2252.html
- E10.5-- VZ (ventricular zone) single layer of cells- have feet that attach to cerebral wall and start dividing. Slightly polarized.
- E11.5--cells begin to differentiate (PP/preplate) into “pioneer” neurons and move upward, laying molecular trail for subsequent differentiating neurons
- E13.5--VZ cells form secondary progenitor population in SVZ, PP (preplate pioneer) cells split into 2 zones (MZ and SP)
- MZ and SP cells tell newly differentiated and migrating cells where they are
- E14.5-17.5-- deep layers populated first and then superficial layers later
- The neuron senses the layer it is in and stops- condense in CP (cortical plate)
6 Layers
Layers I, II, III, IV, V, VI (see "Cortical Layer Review" Z5177691 (talk) 22:57, 23 August 2017 (AEST)
Cell Types
http://www.ruf.rice.edu/~lngbrain/Sidhya/
- Radial Glial cells--in developing cerebellum, hippocampus, cortex
- Migrating neurons glump onto radial glial to migrate- move up these RG cells
- RG Cells for migrating neurons that extend from VZ to get to the outer part of the cortex.
- Fibers that neurons use to migrate from VZ to their final destination
- Allows dividing cells (projector neurons)- to migrate not randomly but radially.
- Radial Glial Cells can divide as well→ overall process requires a lot of membrane
Cell Signaling
Anatomy of the Cerebral Cortex
( Jess)
You might find this helpful (although you need to request copyright permission): "Difference Between Cerebrum and Cerebral Cortex." DifferenceBetween.Com. August 7, 2012. < http://www.differencebetween.com/difference-between-cerebrum-and-vs-cerebral-cortex/ >
Functions of the Cerebral Cortex
( Jess)
For concept:
https://www.youtube.com/watch?v=n6zQbTT0yoY
https://www.youtube.com/watch?v=X-m0JDCw6TE
Abnormalities associated with Cerebral Cortex Development
(Zainab)
DRAFT: https://www.youtube.com/watch?v=luXDQrmMoUU
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992410/
[1]
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547618/
[2]
http://www.cell.com/neuron/fulltext/S0896-6273(00)80749-7?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627300807497%3Fshowall%3Dtrue [3]
https://www.youtube.com/watch?v=l_nTggR7LTE [4]
A- Disorders due to abnormal proliferation, growth or differentiation of neuroblasts
1-Focal cortical dysplasia (FCD)
2-Hemimegalencephaly
3-Microcephaly
4-Tuberous Sclerosis
B- Disorders due to abnormal neuronal migration
5-Heterotopia
Subcortical band heterotopia Periventricular heterotopia
6-Lissencephaly
•undermigration; Classical (Type I) Lisssencephaly
•overmigration;Cobblestone (Type II) lissencephaly
Fragile X-Syndrome
Microlissencephaly
7-Kallmann Syndrome
C- Disorders due to abnormal cortical maturation and organization/folding
8-Polymicrogyria
9-Schizencephaly
•destructive lesions.
D- Disorders due to abnormal Integrity of the Pial Surface
10-Muscle-Eye-Brain Disease
11-Walker-Warburg
12-Fetal Alcohol Spectrum Disorder (FASD)
13-Rett Syndrome
14-Corpus Callosum Agenesis
<html5media height="400" width="500">https://www.youtube.com/watch?v=7zOa3LLrHKc</html5media> [5]
Group Discussion Area (temporary heading)
We are supposed to discuss the project here:
https://moodle.telt.unsw.edu.au/mod/hsuforum/view.php?id=1416354
INFO teachers gave (temporary heading)
PubMed Searches: Cerebral Cortex Development | Cerebrum Development
BMC Dev Biol Search: Cerebral Cortex Development
Recent papers
<pubmed limit=5>Cerebral+Cortex+Development</pubmed>
References
[Harvard Style]
- ↑ Squier, W. and Jansen, A. (2010). Abnormal development of the human cerebral cortex. Journal of Anatomy, [online] 217(4), pp.312-323. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992410/ [Accessed 23 Sep. 2017].
- ↑ Pang, T., Atefy, R. and Sheen, V. (2008). Malformations of Cortical Development. The Neurologist, [online] 14(3), pp.181-191. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547618/ [Accessed 23 Sep. 2017].
- ↑ Christopher A, C. (2017). Genetic Malformations of the Human Cerebral Cortex. Neuron, [online] 23(1), pp.19 - 29. Available at: http://www.cell.com/neuron/fulltext/S0896-6273(00)80749-7?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627300807497%3Fshowall%3Dtrue [Accessed 23 Sep. 2017].
- ↑ Mahfouz, M. (2015). Imaging of cortical formation disorders - DRE 4 - Prof. Dr Mamdouh Mahfouz. [video] Available at: https://www.youtube.com/watch?v=l_nTggR7LTE [Accessed 23 Sep. 2017].
- ↑ Ezzo - Izzo, D. (2007). How the Body Works : The Corpus Callosum. [video] Available at: https://www.youtube.com/watch?v=7zOa3LLrHKc [Accessed 23 Sep. 2017].