Vision - Lens Development: Difference between revisions
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* '''Activated Ras alters lens and corneal development'''<ref><pubmed>20105280</pubmed></ref> "The murine lens and cornea have a common embryonic origin and arise from adjacent regions of the surface ectoderm. ...Collectively, these results suggest that Ras activation a) induces distinct sets of downstream targets in the lens and cornea resulting in distinct cellular responses and b) is sufficient for initiation but not completion of lens fiber differentiation." | * '''Activated Ras alters lens and corneal development'''<ref><pubmed>20105280</pubmed></ref> "The murine lens and cornea have a common embryonic origin and arise from adjacent regions of the surface ectoderm. ...Collectively, these results suggest that Ras activation a) induces distinct sets of downstream targets in the lens and cornea resulting in distinct cellular responses and b) is sufficient for initiation but not completion of lens fiber differentiation." | ||
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==Development Overview== | ==Development Overview== | ||
Revision as of 18:59, 19 May 2013
Introduction
The lens or crystalline lens or aquula (Latin, aquula = a little stream) has a key role in focussing light (with the cornea) upon the neural retina. The lens embryonic origin is from surface ectoderm of the sensory placodes that form in the head region (More? Placodes).
The lens focusses by refracting light as it passes through the biconvex lens, which can be altered in shape (accommodation) by surrounding ciliary muscles. These ciliary muscles are activated (contracted) by parasympathetic innervation from the ciliary ganglion itself innervated by the oculomotor nerve (Cranial Nerve III).
The lens has recently been shown in the chicken model to not be required for specification of the iris and ciliary body.[1]
| Placodes
Some Recent Findings
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Lens Embryology <pubmed limit=5>Lens Embryology</pubmed> |
Development Overview
surface ectoderm -> lens placode -> lens pit -> lens vesicle -> lens fibres -> lens capsule and embryonic/fetal nucleus.
Week 4
Human Embryo Carnegie stage 11 optic pit
Week 5
Week 8
Human embryo Carnegie stage 22
Molecular Signaling
Wnt mediates lens repression by neural crest cells and Transforming growth factor-β[4] (open image for full description)
- Links: Lens Development | Neural Crest Development | Wnt | Lens repression by neural crest cells | Proposed model how NCCs organize the eye | molecular model to explain TGF-β- and Wnt-mediated lens restriction
References
- ↑ <pubmed>17275804</pubmed>
- ↑ <pubmed>20171212</pubmed>
- ↑ <pubmed>20105280</pubmed>
- ↑ Grocott T, Johnson S, Bailey AP, Streit A. Neural crest cells organize the eye via TGF-β and canonical Wnt signalling. Nat Commun. 2011 Apr;2:265. PMID21468017 | Nat Commun.
Glossary Links
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Cite this page: Hill, M.A. (2024, June 26) Embryology Vision - Lens Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Vision_-_Lens_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G