Vision - Lens Development
|Embryology - 4 Jul 2020 Expand to Translate|
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|A personal message from Dr Mark Hill (May 2020)|
|contributors to the site. The good news is Embryology will remain online and I will continue my association with UNSW Australia. I look forward to updating and including the many exciting new discoveries in Embryology!|
The lens or crystalline lens or aquula (Latin, aquula = a little stream) has a key role in focussing light (with the cornea) upon the neural retina. The lens embryonic origin is from surface ectoderm of the sensory placodes that form in the head region (More? Placodes).
The lens focusses by refracting light as it passes through the biconvex lens, which can be altered in shape (accommodation) by surrounding ciliary muscles. These ciliary muscles are activated (contracted) by parasympathetic innervation from the ciliary ganglion itself innervated by the oculomotor nerve (Cranial Nerve CN III).
The lens has recently been shown in the chicken model to not be required for specification of the iris and ciliary body.
Some Recent Findings
|More recent papers|
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
Search term: Lens Embryology
<pubmed limit=5>Lens Embryology</pubmed>
surface ectoderm -> lens placode -> lens pit -> lens vesicle -> lens fibres -> lens capsule and embryonic/fetal nucleus.
Human Embryo Carnegie stage 11 optic pit
The images below link to virtual slides of the human developing eye at Carnegie stage 22. Click on the image to open or select specific regions from the regions of interest links.
Virtual Slide - Regions of Interest
Wnt mediates lens repression by neural crest cells and Transforming growth factor-β (open image for full description)
- Links: Lens Development | Neural Crest Development | Wnt | Lens repression by neural crest cells | Proposed model how NCCs organize the eye | molecular model to explain TGF-β- and Wnt-mediated lens restriction
- Dias da Silva MR, Tiffin N, Mima T, Mikawa T & Hyer J. (2007). FGF-mediated induction of ciliary body tissue in the chick eye. Dev. Biol. , 304, 272-85. PMID: 17275804 DOI.
- Cvekl A & Ashery-Padan R. (2014). The cellular and molecular mechanisms of vertebrate lens development. Development , 141, 4432-47. PMID: 25406393 DOI.
- Cantù C, Zimmerli D, Hausmann G, Valenta T, Moor A, Aguet M & Basler K. (2014). Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development. Genes Dev. , 28, 1879-84. PMID: 25184676 DOI.
- Augusteyn RC. (2010). On the growth and internal structure of the human lens. Exp. Eye Res. , 90, 643-54. PMID: 20171212 DOI.
- Burgess D, Zhang Y, Siefker E, Vaca R, Kuracha MR, Reneker L, Overbeek PA & Govindarajan V. (2010). Activated Ras alters lens and corneal development through induction of distinct downstream targets. BMC Dev. Biol. , 10, 13. PMID: 20105280 DOI.
- Streeter GL. Developmental Horizons In Human Embryos Description Or Age Groups XIX, XX, XXI, XXII, And XXIII, Being The Fifth Issue Of A Survey Of The Carnegie Collection. (1957) Carnegie Instn. Wash. Publ. 611, Contrib. Embryol., 36: 167-196.
- Grocott T, Johnson S, Bailey AP, Streit A. Neural crest cells organize the eye via TGF-β and canonical Wnt signalling. Nat Commun. 2011 Apr;2:265. PMID21468017 | Nat Commun.
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Cite this page: Hill, M.A. (2020, July 4) Embryology Vision - Lens Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Vision_-_Lens_Development
- © Dr Mark Hill 2020, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G