Gastrointestinal Tract - Liver Histology: Difference between revisions
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{{Header}} | |||
==Introduction== | ==Introduction== | ||
[[File:Liver_histology_005.jpg|thumb|300px|Portal Triad]] | |||
[[File:Liver_structure_cartoon.jpg|thumb|300px|Liver cellular structure cartoon]] | [[File:Liver_structure_cartoon.jpg|thumb|300px|Liver cellular structure cartoon]] | ||
This section of notes gives an overview mainly of adult liver histology, see also [[Gastrointestinal Tract - Liver Development|Liver Development]] notes. | This section of notes gives an overview mainly of adult liver histology, see also [[Gastrointestinal Tract - Liver Development|Liver Development]] notes. | ||
[[File:HMsmall.jpg | [[File:HMsmall.jpg]] Page also provides further background information for Medicine phase 1 Health Maintenance B Hepatobiliary System 1 Practical. | ||
'''This page content is not part of the HMB practical class.''' | |||
::'''HMB:''' [[Gastrointestinal Tract - Pancreas Histology|Pancreas Histology]] | [[Gastrointestinal_Tract_-_Liver_Histology|Liver Histology]] | [[Gastrointestinal_Tract_-_Gall_Bladder_Histology|Gall Bladder Histology]] | [[Renal System Histology]] | |||
{{Gastrointestinal Tract Links}} | |||
===Virtual Slides=== | |||
[https://moodle.telt.unsw.edu.au/mod/book/view.php?id=856230&chapterid=106903 Hepatobiliary System 1] (requires Moodle log-in) | |||
* [https://www.best.edu.au/s/an4b8z35/748txiq7/invite/gkdfj4nd?data=8%403!9%4022512!10%40-13716.5&version=1 Liver] (pig) | |||
* [https://www.best.edu.au/s/5ij6ty7z/s7ggj6sj/invite/v26gq25d?data=8%401!9%4012404.5!10%40-10031&version=1 Liver] (human) | |||
* [https://www.best.edu.au/s/idzltlat/q9pryfah/invite/3ylsjrra?data=8%401!9%408827.5!10%40-10560.5&version=1 Liver] (carbon injected) | |||
* [https://www.best.edu.au/s/sazg6qcg/h89up1yj/invite/487bmcmu?data=8%407!9%4015703!10%40-23473.5&version=1 Liver] (reticular fibres) | |||
===Lab Audio=== | |||
[[File:Podcast_icon.jpg]] Wednesday 17 August 2011 3-4 pm G2G4. | |||
{{AudioHMBLiver2011}} | |||
===Images=== | |||
{{Liver Histology Images}} | {{Liver Histology Images}} | ||
==Liver Structure== | ==Liver Structure== | ||
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File:Stage_22_image_132.jpg|Histology - embryonic liver (week 8) | File:Stage_22_image_132.jpg|Histology - embryonic liver (week 8) | ||
File:Stage_22_image_133.jpg|Histology - embryonic liver (week 8) | File:Stage_22_image_133.jpg|Histology - embryonic liver (week 8) | ||
File: | File:Liver histology 009.jpg|Histology - fetal liver HEx40 | ||
File: | File:Liver histology 008.jpg|Histology - fetal liver x100 | ||
</gallery> | </gallery> | ||
=== | ==Adult Histology== | ||
{{Liver Histology Images}} | |||
{| | |||
| [[File:Liver_histology_001.jpg|400px]] | |||
| [[File:Liver_histology_004.jpg|400px]] | |||
|- | |||
| [[File:Liver_histology_002.jpg|400px]] | |||
| [[File:Liver_histology_003.jpg|400px]] | |||
|} | |||
[[File:Liver histology 005.jpg|600px]] | |||
===Unlabeled Large Images=== | |||
<gallery> | <gallery> | ||
File: | File:Liver_histology_101.jpg|Human liver showing central vein | ||
File:Liver_histology_102.jpg|Portal triad | |||
File:Liver_histology_104.jpg|Portal triad | |||
File:Liver_histology_103.jpg|Hepatocytes | |||
</gallery> | </gallery> | ||
==Kupffer Cells and Reticular Fibres== | |||
[[File:Liver- Kupffer cell and reticular fibre.jpg|500px]] | |||
==Hepatocyte Polyploidy== | |||
[[File:Liver_histology_004.jpg|600px]] | |||
Human hepatocytes | |||
[[File:Liver polyploidy 01.jpg|600px]] | |||
Mouse hepatocytes ''in vitro'' and ''in vivo''{{#pmid:20861837|PMID20861837}} | |||
==Liver Histology - Super Resolution== | |||
[[File:Liver sinusoidal endothelial cell fenestrations.jpg|600px]] | |||
Liver sinusoidal endothelial cell fenestrations{{#pmid:26549018|PMID26549018}} | |||
==Liver Histology - Electron Micrograph== | |||
The electron micrographs below show the cellular, vascular and bilary organisation of the liver. | |||
[[File:Liver histology EM01.jpg|400px]] [[File:Liver histology EM02.jpg|400px]] | |||
==References== | |||
<references/> | |||
==Terms== | |||
* '''Glisson's capsule''' (Glisson's sheath) - a collagenous capsule covering the external surface of the liver the outer layer comprising a single layer of mesothelial cells. The capsule also extends into the liver as "sheaths" around the hepatic ducts, hepatic arteries and portal tributaries. Named after Francis Glisson (1599 – 1677) a British anatomist. | |||
* '''Kupffer cells''' - liver macrophage located in sinusoidal space. Named after Karl Wilhelm von Kupffer (1829 - 1902 ) a German anatomist. | |||
* '''sinusoids''' (vascular sinusoids, liver sinusoids) - the spaces between the hepatocytes that are distensible vascular channels lined with fenestrated endothelial cells forming a discontinuous simple squamous epithelium. | |||
* '''stellate cells''' (Ito cells) - Named after Toshio Ito, a twentieth century Japanese physician PMID 11450594 | |||
==External Links== | ==External Links== | ||
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* '''Blue Histology''' [http://www.lab.anhb.uwa.edu.au/mb140/CorePages/Liver/liver.htm#LIVER Liver] | * '''Blue Histology''' [http://www.lab.anhb.uwa.edu.au/mb140/CorePages/Liver/liver.htm#LIVER Liver] | ||
* '''UNSW Virtual Slides''' Medicine phase 1 [http://vslides.unsw.edu.au/VirtualSlideV2.nsf/id/4F2D04 Health Maintenance B Hepatobiliary System 1 Practical] (requires login for access). | * '''UNSW Virtual Slides''' Medicine phase 1 [http://vslides.unsw.edu.au/VirtualSlideV2.nsf/id/4F2D04 Health Maintenance B Hepatobiliary System 1 Practical] (requires login for access). | ||
* '''UIOWA Virtual Slidebox of Histology''' [http://www.path.uiowa.edu/cgi-bin-pub/vs/fpx_browse.cgi?cat=o_liver&div=nlm Liver and biliary system] | |||
{{Template:Glossary}} | {{Template:Glossary}} |
Latest revision as of 13:26, 25 February 2019
Embryology - 10 Jun 2024 Expand to Translate |
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Introduction
This section of notes gives an overview mainly of adult liver histology, see also Liver Development notes.
Page also provides further background information for Medicine phase 1 Health Maintenance B Hepatobiliary System 1 Practical.
This page content is not part of the HMB practical class.
Virtual Slides
Hepatobiliary System 1 (requires Moodle log-in)
Lab Audio
Wednesday 17 August 2011 3-4 pm G2G4.
- Links: listen 1 | download 1 | listen 2 | download 2 | listen 3 | download 3 | listen 4 | download 4 | listen 5 | download 5 | Liver Histology Background
Images
- Liver Histology: Central vein (label) | Central vein (unlabel) | Portal triad 1 (label) | Portal triad 2 (label) | Portal triad (unlabel) | Hepatocytes (unlabel) | Hepatocytes polyploid (label) | Liver - reticular connective tissue (LP) | Liver - reticular connective tissue (HP) | Liver - fetal (HP) | Liver - fetal (HP) | Liver Development | GIT Histology
Liver Structure
Liver Lobule
This looped animation shows the different ways of interpreting the cellular structure of the liver lobule. |
Liver Blood Flow
Dual blood supply of the liver merges upon entry into the liver lobule at the portal field.
|
Hepatocytes
These are the adult functional cells forming the majority of the liver (80% of the cells).
Many different functions including:
|
Histology Images
Development Histology
Adult Histology
- Liver Histology: Central vein (label) | Central vein (unlabel) | Portal triad 1 (label) | Portal triad 2 (label) | Portal triad (unlabel) | Hepatocytes (unlabel) | Hepatocytes polyploid (label) | Liver - reticular connective tissue (LP) | Liver - reticular connective tissue (HP) | Liver - fetal (HP) | Liver - fetal (HP) | Liver Development | GIT Histology
Unlabeled Large Images
Kupffer Cells and Reticular Fibres
Hepatocyte Polyploidy
Human hepatocytes
Mouse hepatocytes in vitro and in vivo[1]
Liver Histology - Super Resolution
Liver sinusoidal endothelial cell fenestrations[2]
Liver Histology - Electron Micrograph
The electron micrographs below show the cellular, vascular and bilary organisation of the liver.
References
- ↑ Duncan AW, Taylor MH, Hickey RD, Hanlon Newell AE, Lenzi ML, Olson SB, Finegold MJ & Grompe M. (2010). The ploidy conveyor of mature hepatocytes as a source of genetic variation. Nature , 467, 707-10. PMID: 20861837 DOI.
- ↑ Mönkemöller V, Øie C, Hübner W, Huser T & McCourt P. (2015). Multimodal super-resolution optical microscopy visualizes the close connection between membrane and the cytoskeleton in liver sinusoidal endothelial cell fenestrations. Sci Rep , 5, 16279. PMID: 26549018 DOI.
Terms
- Glisson's capsule (Glisson's sheath) - a collagenous capsule covering the external surface of the liver the outer layer comprising a single layer of mesothelial cells. The capsule also extends into the liver as "sheaths" around the hepatic ducts, hepatic arteries and portal tributaries. Named after Francis Glisson (1599 – 1677) a British anatomist.
- Kupffer cells - liver macrophage located in sinusoidal space. Named after Karl Wilhelm von Kupffer (1829 - 1902 ) a German anatomist.
- sinusoids (vascular sinusoids, liver sinusoids) - the spaces between the hepatocytes that are distensible vascular channels lined with fenestrated endothelial cells forming a discontinuous simple squamous epithelium.
- stellate cells (Ito cells) - Named after Toshio Ito, a twentieth century Japanese physician PMID 11450594
External Links
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
- Blue Histology Liver
- UNSW Virtual Slides Medicine phase 1 Health Maintenance B Hepatobiliary System 1 Practical (requires login for access).
- UIOWA Virtual Slidebox of Histology Liver and biliary system
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2024, June 10) Embryology Gastrointestinal Tract - Liver Histology. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Gastrointestinal_Tract_-_Liver_Histology
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G