Neural - Telencephalon Development

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Introduction

Stage10 sem6.jpg

Neural development is one of the earliest systems to begin and the last to be completed after birth. This development generates the most complex structure within the embryo and the long time period of development means in utero insult during pregnancy may have consequences to development of the nervous system.

The early central nervous system begins as a simple neural plate that folds to form a groove then tube, open initially at each end. Failure of these opening to close contributes a major class of neural abnormalities (neural tube defects).

Within the neural tube stem cells generate the 2 major classes of cells that make the majority of the nervous system : neurons and glia. Both these classes of cells differentiate into many different types generated with highly specialized functions and shapes. This section covers the establishment of neural populations, the inductive influences of surrounding tissues and the sequential generation of neurons establishing the layered structure seen in the brain and spinal cord.

  • Neural development beginnings quite early, therefore also look at notes covering Week 3- neural tube and Week 4-early nervous system.
  • Development of the neural crest and sensory systems (hearing/vision/smell) are only introduced in these notes and are covered in other notes sections.


Neural Links: neural | ventricular | ectoderm | Stage 22 | gliogenesis | neural fetal | Medicine Lecture - Neural | Lecture - Ectoderm | Lecture - Neural Crest | Lab - Early Neural | neural crest | Sensory | neural abnormalities | folic acid | iodine deficiency | Fetal Alcohol Syndrome | Postnatal | Postnatal - Neural Examination | Histology | Historic Neural | Category:Neural
Neural Parts: neural | prosencephalon | telencephalon cerebrum | amygdala | hippocampus | basal ganglia | lateral ventricles | diencephalon | Epithalamus | thalamus | hypothalamus‎ | pituitary | pineal | third ventricle | mesencephalon | tectum | cerebral aqueduct | rhombencephalon | metencephalon | pons | cerebellum | myelencephalon | medulla oblongata | spinal cord | neural vascular | meninges | Category:Neural

Some Recent Findings

  • The Mammalian DM Domain Transcription Factor Dmrta2 Is Required for Early Embryonic Development of the Cerebral Cortex[1]"Development of the mammalian telencephalon is precisely organized by a combination of extracellular signaling events derived from signaling centers and transcription factor networks. Using gene expression profiling of the developing mouse dorsal telencephalon, we found that the DM domain transcription factor Dmrta2 (doublesex and mab-3-related transcription factor a2) is involved in the development of the dorsal telencephalon."
  • The transcription factor Foxg1 regulates telencephalic progenitor proliferation[2] "The transcription factor Foxg1 is an important regulator of telencephalic cell cycles. Its inactivation causes premature lengthening of telencephalic progenitor cell cycles and increased neurogenic divisions, leading to severe hypoplasia of the telencephalon. ....We conclude that Foxg1 exerts control over telencephalic progenitor proliferation by cell autonomous mechanisms that include the regulation of Pax6, which itself is known to regulate proliferation cell autonomously in a regional manner."
  • Populations of subplate and interstitial neurons in fetal and adult human telencephalon[3] "In the adult human telencephalon, subcortical (gyral) white matter contains a special population of interstitial neurons considered to be surviving descendants of fetal subplate neurons [Kostovic & Rakic (1980) Cytology and the time of origin of interstitial neurons in the white matter in infant and adult human and monkey telencephalon. J Neurocytol9, 219]. We designate this population of cells as superficial (gyral) interstitial neurons and describe their morphology and distribution in the postnatal and adult human cerebrum. Human fetal subplate neurons cannot be regarded as interstitial, because the subplate zone is an essential part of the fetal cortex, the major site of synaptogenesis and the 'waiting' compartment for growing cortical afferents, and contains both projection neurons and interneurons with distinct input-output connectivity. However, although the subplate zone is a transient fetal structure, many subplate neurons survive postnatally as superficial (gyral) interstitial neurons. The fetal white matter is represented by the intermediate zone and well-defined deep periventricular tracts of growing axons, such as the corpus callosum, anterior commissure, internal and external capsule, and the fountainhead of the corona radiata."
  • Ephrins guide migrating cortical interneurons in the basal telencephalon[4] "Cortical interneurons are born in the proliferative zones of the ganglionic eminences in the subpallium and migrate to the developing cortex along well-defined tangential routes. The mechanisms regulating interneuron migration are not completely understood. ... Together, these results suggest that ephrin-A3 acts as a repulsive cue that restricts cortical interneurons from entering inappropriate regions and thus contributes to define the migratory route of cortical interneurons."
  • FoxG1 and TLE2 act cooperatively to regulate ventral telencephalon formation[5] "FoxG1 is a conserved transcriptional repressor that plays a key role in the specification, proliferation and differentiation of the telencephalon, and is expressed from the earliest stages of telencephalic development through to the adult. ...Knocking down either FoxG1 or TLE2 disrupts the development of the ventral telencephalon, supporting the idea that endogenous TLE2 and FoxG1 work together to specify the ventral telencephalon."
More recent papers  
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This table shows an automated computer PubMed search using the listed sub-heading term.

  • Therefore the list of references do not reflect any editorial selection of material based on content or relevance.
  • References appear in this list based upon the date of the actual page viewing.

References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.

Links: References | Discussion Page | Pubmed Most Recent | Journal Searches


Search term: Telencephalon Embryology

Henriette Franz, Alejandro Villarreal, Stefanie Heidrich, Pavankumar Videm, Fabian Kilpert, Ivan Mestres, Federico Calegari, Rolf Backofen, Thomas Manke, Tanja Vogel DOT1L promotes progenitor proliferation and primes neuronal layer identity in the developing cerebral cortex. Nucleic Acids Res.: 2018; PubMed 30329130

Dimka Hinova-Palova, Alexandar Iliev, Lawrence Edelstein, Boycho Landzhov, Georgi Kotov, Adrian Paloff Electron microscopic study of Golgi-impregnated and gold-toned neurons and fibers in the claustrum of the cat. J. Mol. Histol.: 2018; PubMed 30306356

Brian G Rash, Nicola Micali, Anita J Huttner, Yury M Morozov, Tamas L Horvath, Pasko Rakic Metabolic regulation and glucose sensitivity of cortical radial glial cells. Proc. Natl. Acad. Sci. U.S.A.: 2018; PubMed 30224493

Anca B Mihalas, Robert F Hevner Clonal analysis reveals laminar fate multipotency and daughter cell apoptosis of mouse cortical intermediate progenitors. Development: 2018, 145(17); PubMed 30217810

Sophie R Miller, Cristina Benito, Rhona Mirsky, Kristján R Jessen, Clare V H Baker Neural crest Notch/Rbpj signaling regulates olfactory gliogenesis and neuronal migration. Genesis: 2018, 56(6-7);e23215 PubMed 30134068

Development Overview

Neuralation begins at the trilaminar embryo with formation of the notochord and somites, both of which underly the ectoderm and do not contribute to the nervous system, but are involved with patterning its initial formation. The central portion of the ectoderm then forms the neural plate that folds to form the neural tube, that will eventually form the entire central nervous system.

Early developmental sequence: Epiblast - Ectoderm - Neural Plate - Neural groove and Neural Crest - Neural Tube and Neural Crest


Neural Tube Primary Vesicles Secondary Vesicles Adult Structures
week 3 week 4 week 5 adult
neural plate
neural groove
neural tube

Brain
Prosencephalon Telencephalon Rhinencephalon, Amygdala, Hippocampus, Cerebrum (Cortex), Hypothalamus, Pituitary | Basal Ganglia, lateral ventricles
Diencephalon Epithalamus, Thalamus, Subthalamus, Pineal, third ventricle
Mesencephalon Mesencephalon Tectum, Cerebral peduncle, Pretectum, cerebral aqueduct
Rhombencephalon Metencephalon Pons, Cerebellum
Myelencephalon Medulla Oblongata
Spinal Cord

Adult Cerebral Cortex

Each lobe below is further divided into regions.

  • Frontal lobe
  • Parietal lobe
  • Occipital lobe
  • Temporal lobe
  • Limbic lobe
  • Insular cortex
  • Interlobar sulci/fissures

Early Brain Vesicles

Primary Vesicles

CNS primary vesicles.jpg

Secondary Vesicles

CNS secondary vesicles.jpg


Insular Cortex

(insula, insulary cortex, insular lobe) Region from the telencephalon forming part of the cerebral cortex located deep within the lateral fissure (Sylvian fissure) between the temporal lobe and the frontal lobe. Adult roles in consciousness, emotion, sensory and homeostasis, see review.[6]

  • less than 2% of total cortical surface area
  • receives afferents from some sensory thalamic nuclei
  • connected with amygdala and many limbic and association cortical areas


Historical Background  
  • 1928 Rose[7]
  • 1940 Brockhaus</ref>Brockhaus H. Die Cyto- und Myeloarchitektonik des Cortex claustralis und des Claustrum beim Menschen. (1940) Journal fuer Psychologie und Neurologie, 49:249–348.</ref>
  • 1985 Mesulam and Mufson[8]

Molecular Development

Regulatory Networks

Telencephalon gene regulatory network.jpg

Algorithm-based gene regulatory network structure for dorsal and ventral telencephalon development.[9]

To highlight the key regulators, the nodes representing genes predicted to be the parent of at least nine other genes are largest in size (Sox9, Mef2a, Elavl4 and Pou6f1), whereas those that are predicted to regulate at least five other genes are medium in size (Ngn2, Centg3, Tef, Tcf4, Wnt7b, Pou2f1, Yy1, Dll1, E2f1, Arx, and Creb).

Netrin-1 Signaling

Telencephalon- Netrin-1 signaling thalamocortical projections.jpg Model of the Role of Netrin-1 Signaling in the Topography of Thalamocortical Projections in the Ventral Telencephalon[10]

Models summarizing previous[11] and above reference[10] findings regarding the axon guidance cues controlling the topographic sorting of thalamocortical axons in the ventral telencephalon.


Links: OMIM - NETRIN 1 | Mouse Development

References

  1. Konno D, Iwashita M, Satoh Y, Momiyama A, Abe T, Kiyonari H & Matsuzaki F. (2012). The mammalian DM domain transcription factor Dmrta2 is required for early embryonic development of the cerebral cortex. PLoS ONE , 7, e46577. PMID: 23056351 DOI.
  2. . (). . , , . PMID: 221418559
  3. Judaš M, Sedmak G, Pletikos M & Jovanov-Milošević N. (2010). Populations of subplate and interstitial neurons in fetal and adult human telencephalon. J. Anat. , 217, 381-99. PMID: 20979586 DOI.
  4. Rudolph J, Zimmer G, Steinecke A, Barchmann S & Bolz J. (2010). Ephrins guide migrating cortical interneurons in the basal telencephalon. Cell Adh Migr , 4, 400-8. PMID: 20473036
  5. Roth M, Bonev B, Lindsay J, Lea R, Panagiotaki N, Houart C & Papalopulu N. (2010). FoxG1 and TLE2 act cooperatively to regulate ventral telencephalon formation. Development , 137, 1553-62. PMID: 20356955 DOI.
  6. Nieuwenhuys R. (2012). The insular cortex: a review. Prog. Brain Res. , 195, 123-63. PMID: 22230626 DOI.
  7. Rose M. Die Inselrinde des Menschen und der Tiere. (1928) Journal fuer Psychologie und Neurologie, 37: 467–624
  8. Mesulam MM. and Mufson EJ. The insula of Reil in man and monkey. (1985) A. Peters, E.G. Jones (Eds.), Association and auditory cortices, Plenum, New York, pp. 179–226
  9. Gohlke JM, Armant O, Parham FM, Smith MV, Zimmer C, Castro DS, Nguyen L, Parker JS, Gradwohl G, Portier CJ & Guillemot F. (2008). Characterization of the proneural gene regulatory network during mouse telencephalon development. BMC Biol. , 6, 15. PMID: 18377642 DOI.
  10. 10.0 10.1 Powell AW, Sassa T, Wu Y, Tessier-Lavigne M & Polleux F. (2008). Topography of thalamic projections requires attractive and repulsive functions of Netrin-1 in the ventral telencephalon. PLoS Biol. , 6, e116. PMID: 18479186 DOI.
  11. Dufour A, Seibt J, Passante L, Depaepe V, Ciossek T, Frisén J, Kullander K, Flanagan JG, Polleux F & Vanderhaeghen P. (2003). Area specificity and topography of thalamocortical projections are controlled by ephrin/Eph genes. Neuron , 39, 453-65. PMID: 12895420

Reviews

Nomura T, Hattori M & Osumi N. (2009). Reelin, radial fibers and cortical evolution: insights from comparative analysis of the mammalian and avian telencephalon. Dev. Growth Differ. , 51, 287-97. PMID: 19210541 DOI.

Hébert JM & Fishell G. (2008). The genetics of early telencephalon patterning: some assembly required. Nat. Rev. Neurosci. , 9, 678-85. PMID: 19143049 DOI.


Articles

Yu W, Wang Y, McDonnell K, Stephen D & Bai CB. (2009). Patterning of ventral telencephalon requires positive function of Gli transcription factors. Dev. Biol. , 334, 264-75. PMID: 19632216 DOI.

Gulacsi AA & Anderson SA. (2008). Beta-catenin-mediated Wnt signaling regulates neurogenesis in the ventral telencephalon. Nat. Neurosci. , 11, 1383-91. PMID: 18997789 DOI.

. (). . , , . PMID: 18682721

Rash BG & Grove EA. (2007). Patterning the dorsal telencephalon: a role for sonic hedgehog?. J. Neurosci. , 27, 11595-603. PMID: 17959802 DOI.

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Cite this page: Hill, M.A. (2018, December 11) Embryology Neural - Telencephalon Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Neural_-_Telencephalon_Development

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© Dr Mark Hill 2018, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G