Neural - Metencephalon Development
|Embryology - 9 Dec 2018 Expand to Translate|
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Neural development is one of the earliest systems to begin and the last to be completed after birth. This development generates the most complex structure within the embryo and the long time period of development means in utero insult during pregnancy may have consequences to development of the nervous system. The early central nervous system begins as a simple neural plate that folds to form a groove then tube, open initially at each end. Failure of these opening to close contributes a major class of neural abnormalities (neural tube defects).
The midbrain/hindbrain boundary (MHB, isthmic organizer) is a secondary organizer region lying at the junction of the Mesencephalon and Metencephalon.
- Neural Parts: neural | prosencephalon | telencephalon cerebrum | amygdala | hippocampus | basal ganglia | lateral ventricles | diencephalon | Epithalamus | thalamus | hypothalamus | pituitary | pineal | third ventricle | mesencephalon | tectum | cerebral aqueduct | rhombencephalon | metencephalon | pons | cerebellum | myelencephalon | medulla oblongata | spinal cord | neural vascular | meninges | Category:Neural
Some Recent Findings
|More recent papers|
This table shows an automated computer PubMed search using the listed sub-heading term.
References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.
César Augusto Pinheiro Ferreira Alves, Diego Cardoso Fragoso, Fabrício Guimarães Gonçalves, Victor Hugo Marussi, Lázaro Luís Faria do Amaral Cerebellar Ataxia in Children: A Clinical and MRI Approach to the Differential Diagnosis. Top Magn Reson Imaging: 2018, 27(4);275-302 PubMed 30086112
Bea R H van den Bergh, Robert Dahnke, Maarten Mennes Prenatal stress and the developing brain: Risks for neurodevelopmental disorders. Dev. Psychopathol.: 2018, 30(3);743-762 PubMed 30068407
Zeferino Junior Demartini, Tatiana von Hertwig de Oliveira, Ricardo Munhoz da Rocha Guimarães, Alfredo Löhr, Gelson Luis Koppe, Luana A Maranha Gatto Posterior Inferior Cerebellar Artery Origin over the C2 Posterior Arch. Pediatr Neurosurg: 2018, 53(5);364-366 PubMed 30048991
Menno R Germans, Zsolt Kulcsar, Luca Regli, Oliver Bozinov Clipping of Ruptured Aneurysm of Lateral Spinal Artery Associated with Anastomosis to Distal Posterior Inferior Cerebellar Artery: A Case Report. World Neurosurg: 2018, 117;186-189 PubMed 29935320
Jan Voogd, Peter J Koehler Historic notes on anatomic, physiologic, and clinical research on the cerebellum. Handb Clin Neurol: 2018, 154;3-26 PubMed 29903448
Neuralation begins at the trilaminar embryo with formation of the notochord and somites, both of which underly the ectoderm and do not contribute to the nervous system, but are involved with patterning its initial formation. The central portion of the ectoderm then forms the neural plate that folds to form the neural tube, that will eventually form the entire central nervous system.
- Early developmental sequence: Epiblast - Ectoderm - Neural Plate - Neural groove and Neural Crest - Neural Tube and Neural Crest
|Neural Tube||Primary Vesicles||Secondary Vesicles||Adult Structures|
|week 3||week 4||week 5||adult|
|Prosencephalon||Telencephalon||Rhinencephalon, Amygdala, Hippocampus, Cerebrum (Cortex), Hypothalamus, Pituitary | Basal Ganglia, lateral ventricles|
|Diencephalon||Epithalamus, Thalamus, Subthalamus, Pineal, third ventricle|
|Mesencephalon||Mesencephalon||Tectum, Cerebral peduncle, Pretectum, cerebral aqueduct|
Early Brain Vesicles
- Harukazu Nakamura, Tatsuya Sato, Asuka Suzuki-Hirano Isthmus organizer for mesencephalon and metencephalon. Dev. Growth Differ.: 2008, 50 Suppl 1;S113-8 PubMed 18494704
- Eiji Matsunaga, Tatsuya Katahira, Harukazu Nakamura Role of Lmx1b and Wnt1 in mesencephalon and metencephalon development. Development: 2002, 129(22);5269-77 PubMed 12399317
- M Wassef, A L Joyner Early mesencephalon/metencephalon patterning and development of the cerebellum. Perspect Dev Neurobiol: 1997, 5(1);3-16 PubMed 9509514
Nicholas D E Greene, Andrew J Copp Development of the vertebrate central nervous system: formation of the neural tube. Prenat. Diagn.: 2009, 29(4);303-11 PubMed 19206138
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Cite this page: Hill, M.A. (2018, December 9) Embryology Neural - Metencephalon Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Neural_-_Metencephalon_Development
- © Dr Mark Hill 2018, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G