Musculoskeletal System - Pelvis Development

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Stage20-23 limbs b.jpg

Introduction

The Embryonic Pelvic Girdle (week 5)
Adult appendicular skeleton
Hip bone

The pelvis is a developmentally complex skeletal structure requiring the fusion of separate elements and articulation with both the axial skeleton and lower limb. Postnatally, the human upright posture has also placed highly species specific physical demands on this structure. Developmental dysplasia of the hip is also one of the 3 most common (along with cleft palate, cleft lip) skeletal abnormalities.


The skeletal pelvis consists of: the sacrum and coccyx (axial skeleton), and pelvic girdle formed by a pair of hip bones (appendicular skeleton). Before puberty, he pelvic girdle also consists of three unfused bones: the ilium, ischium, and pubis. In chicken, the entire pelvic girdle originates from the somatopleure mesoderm (somite levels 26 to 35) and the ilium, but not of the pubis and ischium, depends on somitic and ectodermal signals.[1]

The mesoderm forms nearly all the connective tissues of the musculoskeletal system. Each tissue (cartilage, bone, and muscle) goes through many different mechanisms of differentiation.

The musculoskeletal system consists of skeletal muscle, bone, and cartilage and is mainly mesoderm in origin with some neural crest contribution.

The intraembryonic mesoderm can be broken into paraxial, intermediate and lateral mesoderm relative to its midline position. During the 3rd week the paraxial mesoderm forms into "balls" of mesoderm paired either side of the neural groove, called somites.

Somites appear bilaterally as pairs at the same time and form earliest at the cranial (rostral,brain) end of the neural groove and add sequentially at the caudal end. This addition occurs so regularly that embryos are staged according to the number of somites that are present. Different regions of the somite differentiate into dermomyotome (dermal and muscle component) and sclerotome (forms vertebral column). An example of a specialized musculoskeletal structure can be seen in the development of the limbs.

Skeletal muscle forms by fusion of mononucleated myoblasts to form mutinucleated myotubes. Bone is formed through a lengthy process involving ossification of a cartilage formed from mesenchyme. Two main forms of ossification occur in different bones, intramembranous (eg skull) and endochondrial (eg limb long bones) ossification. Ossification continues postnatally, through puberty until mid 20s. Early ossification occurs at the ends of long bones.

The pelvis is also covered in some urogenital studies.[2][3][4][5] Musculoskeletal and limb abnormalities are also one of the largest groups of congenital abnormalities.


Links: pelvis | shoulder


Historic Pelvis  

Thomson A. The sexual differences of the fetal pelvis. (1899) J Anat Physiol. 33(3): 359-380.

Ruth EB. A study of the development of the mammalian pelvis. (1932) Anat. Rec. 53(2): 208 -

Musculoskeletal Links: Introduction | mesoderm | somitogenesis | limb | cartilage | bone | bone timeline | shoulder | pelvis | axial skeleton | skull | joint | skeletal muscle | muscle timeline | tendon | diaphragm | Lecture - Musculoskeletal | Lecture Movie | musculoskeletal abnormalities | limb abnormalities | developmental hip dysplasia | cartilage histology | bone histology | Skeletal Muscle Histology | Category:Musculoskeletal
Historic Musculoskeletal Embryology  
1853 Bone | 1885 Sphenoid | 1902 - Pubo-femoral Region | Spinal Column and Back | Body Segmentation | Cranium | Body Wall, Ribs, and Sternum | Limbs | 1901 - Limbs | 1902 - Arm Development | 1906 Human Embryo Ossification | 1906 Lower limb Nerves and Muscle | 1907 - Muscular System | Skeleton and Limbs | 1908 Vertebra | 1908 Cervical Vertebra | 1909 Mandible | 1910 - Skeleton and Connective Tissues | Muscular System | Coelom and Diaphragm | 1913 Clavicle | 1920 Clavicle | 1921 - External body form | Connective tissues and skeletal | Muscular | Diaphragm | 1929 Rat Somite | 1932 Pelvis | 1940 Synovial Joints | 1943 Human Embryonic, Fetal and Circumnatal Skeleton | 1947 Joints | 1949 Cartilage and Bone | 1957 Chondrification Hands and Feet | 1968 Knee

Some Recent Findings

  • Cartilage formation in the pelvic skeleton during the embryonic and early-fetal period[6] "The pelvic skeleton is formed via endochondral ossification. However, it is not known how the normal cartilage is formed before ossification occurs. Furthermore, the overall timeline of cartilage formation and the morphology of the cartilage in the pelvis are unclear. In this study, cartilage formation in the pelvic skeletons of 25 human fetuses (crown-rump length [CRL] = 11.9-75.0 mm) was observed using phase-contrast computed tomography and 7T magnetic resonance imaging.
  • Review - Ontogeny of the Human Pelvis[7] "The human pelvis has evolved over time into a remarkable structure, optimised into an intricate architecture that transfers the entire load of the upper body into the lower limbs, while also facilitating bipedal movement. The pelvic girdle is composed of two hip bones, os coxae, themselves each formed from the gradual fusion of the ischium, ilium and pubis bones. Unlike the development of the classical long bones, a complex timeline of events must occur in order for the pelvis to arise from the embryonic limb buds. An initial blastemal structure forms from the mesenchyme, with chondrification of this mass leading to the first recognisable elements of the pelvis. Primary ossification centres initiate in utero, followed post-natally by secondary ossification at a range of locations, with these processes not complete until adulthood.
More recent papers  
Mark Hill.jpg
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This table shows an automated computer PubMed search using the listed sub-heading term.

  • Therefore the list of references do not reflect any editorial selection of material based on content or relevance.
  • References appear in this list based upon the date of the actual page viewing.

References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.

Links: References | Discussion Page | Pubmed Most Recent | Journal Searches


Note this search term may result in listing some papers related to renal development.

Search term: Pelvis Embryology

Yddoussalah Othmane, Alae Touzani [Isolated male epispadias]. [Epispadias masculin isolé.] Pan Afr Med J: 2017, 28;202 PubMed 29610640

Gemma Biviá-Roig, Juan Francisco Lisón, Daniel Sánchez-Zuriaga Changes in trunk posture and muscle responses in standing during pregnancy and postpartum. PLoS ONE: 2018, 13(3);e0194853 PubMed 29584774

Amanda T Whitaker, James Kasser, Young-Jo Kim Spinal dysraphism and dislocated hip: Beware of anomalous sciatic nerve through Ilium, a case report. Medicine (Baltimore): 2018, 97(12);e9770 PubMed 29561460

L Asensio Romero, M Asensio Gómez, A Prats-Galino, J A Juanes Méndez 3D Models of Female Pelvis Structures Reconstructed and Represented in Combination with Anatomical and Radiological Sections. J Med Syst: 2018, 42(3);37 PubMed 29333592

Hubert Scheuerlein, Frank Henschke, Ferdinand Köckerling Wilhelm von Waldeyer-Hartz-A Great Forefather: His Contributions to Anatomy with Particular Attention to "His" Fascia. Front Surg: 2017, 4;74 PubMed 29255713


Search term: Pelvis Development

Byung-Ho Yoon, In Keun Park, Yerl-Bo Sung Ankylosing Neurogenic Myositis Ossificans of the Hip: A Case Series and Review of Literature. Hip Pelvis: 2018, 30(2);86-91 PubMed 29896457

Marianna Romei, Laura M Oudenhoven, Petra E M van Schie, Willem J R van Ouwerkerk, Marjolein M van der Krogt, Annemieke I Buizer Evolution of gait in adolescents and young adults with spastic diplegia after selective dorsal rhizotomy in childhood: A 10 year follow-up study. Gait Posture: 2018, 64;108-113 PubMed 29894977

Sepp De Raedt, Inger Mechlenburg, Maiken Stilling, Lone Rømer, Ryan J Murphy, Mehran Armand, Jyri Lepistö, Marleen de Bruijne, Kjeld Søballe Reliability of computer-assisted periacetabular osteotomy using a minimally invasive approach. Int J Comput Assist Radiol Surg: 2018; PubMed 29876786

Basmah A Rafie, Omar J AbuHamdan, Nawal S Trengganu, Badr H Althebyani, Bassam S Almatrafi Torsion of a wandering spleen as a cause of portal hypertension and mesenteric varices: a rare aetiology. J Surg Case Rep: 2018, 2018(5);rjy107 PubMed 29876050

Azfar Neyaz, Nuzhat Husain, Nidhi Anand, Pallavi Srivastava Rare paratesticular aggressive angiomyxoma with negative oestrogen and progesterone receptors in a male patient. BMJ Case Rep: 2018, 2018; PubMed 29866663

Textbooks

  • The Developing Human: Clinically Oriented Embryology (8th Edition) by Keith L. Moore and T.V.N Persaud - Moore & Persaud Chapter 15 the skeletal system
  • Larsen’s Human Embryology by GC. Schoenwolf, SB. Bleyl, PR. Brauer and PH. Francis-West - Chapter 11 Limb Dev (bone not well covered in this textbook)
  • Before we Are Born (5th ed.) Moore and Persaud Chapter 16,17: p379-397, 399-405
  • Essentials of Human Embryology Larson Chapter 11 p207-228

Timeline

The following timeline data comes from a recent CT and MRI study of late human embryos from the Kyoto Collection.[6]

Human Pelvis Development
Carnegie Stage Event
18 chondrification centres of the ilium, ischium, and pubis first appears. Located around the acetabulum and grew radially.
20 iliac crest formed while the iliac body's central part remained chondrified.
22 Sacroiliac joint forms.
22 Iliac body is discoid. The growth rate was greater in the ilium than in the sacrum-coccyx, pubis, and ischium.
23 Articulation of the pubic symphysis, connection of the articular column in the sacrum, and Y-shape connection of the three parts of the hip bones to the acetabulum.
Early Fetal connection of the ischium and pubic ramus.
Data from human CT and MRI study.[6]
   Links: pelvis | pelvis timeline | joint | limb | timeline


Muscle Development (Myogenesis)

  • Early myogenic progenitor cells in the dermomyotome can be initially identified by the transcription factor Pax3.
  • Subsequent myogenic program development then depends on the myogenic determination factors (Myf5, MyoD, and MRF4), both Myf5 and MyoD are expressed in the limbs.
  • Final differentiation of these cells into post-mitotic muscle fibers in the limb bud is regulated by another myogenic determination factor, Myogenin.

(Some of the above text modified from[8]

Links: Muscle Development

Limb Bone

Limb sox9 and Wnt6 expression[9]
Chicken- limb bud chondrogenesis

Bone formation within the limb occurs by endochondral ossification of a pre-existing cartilage template. Ossification then replaces the existing cartilage except in the regions of articulation, where cartilage remains on the surface of the bone within the joint. Therefore bone development in the limb is initially about cartilage development or chondrogenesis.

In addition, there are two quite separate aspects to this development.

  1. Pattern - where the specific regions will commence to form cartilage, which will be different for each cartilage element.
  2. Chondrogenesis - the differentiation of mesoderm to form cartilage, which will be essentially the same program for all cartilage templates.

A recent study has identified that the overlying limb surface ectoderm potentially inhibits limb early chondrogenesis through Wnt6 signaling.[9]


Links: Cartilage Development | Bone Development

Molecular

Fibroblast Growth Factors

  • Fgf8 - morphogen gradient forms by a source-sink mechanism with freely diffusing molecules.[10]

T-box Transcription Factors

Abnormalities

Developmental Dysplasia of the Hip

X-Ray Developmental Dysplasia of the Hip
Acetabular angle[11]

Developmental dysplasia of the hip ((DDH) or congenital hip dislocation is one of the 3 most common skeletal abnormalities and can range from unilateral or bilateral instability to complete dislocation at the femur acetabulum of the lower limb. See the recommendation statement for screening for developmental dysplasia of the hip.[12]

  • Instability: 1:60 at birth; 1:240 at 1 wk: Dislocation untreated; 1:700
  • congenital instability of hip, later dislocates by muscle pulls or gravity
  • familial predisposition female predominance
  • Growth of femoral head, acetabulum and innominate bone are delayed until the femoral head fits firmly into the acetabulum.

International Classification of Diseases

Q65 Congenital deformities of hip

  • Q65.0 Congenital dislocation of hip, unilateral
  • Q65.1 Congenital dislocation of hip, bilateral
  • Q65.2 Congenital dislocation of hip, unspecified
  • Q65.3 Congenital subluxation of hip, unilateral
  • Q65.4 Congenital subluxation of hip, bilateral
  • Q65.5 Congenital subluxation of hip, unspecified
  • Q65.6 Unstable hip Dislocatable hip Subluxatable hip
  • Q65.8 Other congenital deformities of hip Anteversion of femoral neck Congenital acetabular dysplasia Congenital coxa: valga vara
  • Q65.9 Congenital deformity of hip, unspecified

Barlow test

(Barlow maneuver) A clinical term to describe a physical examination of the newborn for Developmental dysplasia of the hip (DDH). The examiner adducts the hip (bringing the thigh towards the midline) while applying light pressure on the knee, directing the force posteriorly. A positive sign is the hip being dislocatable, if the hip can be popped out of socket with this test. This test is then combined with the Ortolani test (manoeuvre). The test is named after Thomas Barlow (1845 – 1945) a British royal physician.

Ortolani test

(Ortolani manoeuvre) A clinical term to describe a physical examination of the newborn for developmental dysplasia of the hip (DDH). This is a test for posterior dislocation of the hip. Using the examiner's thumb, abduct the infant's leg, while using the examiner's index finger to place anterior pressure on the greater trochanter. A positive sign is a distinctive 'clunk' which can be heard and felt as the femoral head relocates anteriorly into the acetabulum, usually becomes negative after 2 months of age. This test is combined with the Barlow test (maneuver). Named after Marino Ortolani, the test developer in 1976.

Abduction Splints

There is variable evidence for the use of abduction splinting during onset of walking in children on the maturation of mild dysplastic hips.[11]


Shoulder

The skeletal shoulder consists of: the clavicle (collarbone), the scapula (shoulder blade), and the humerus. Development of his region occurs through both forms of ossification processes.


Links: Shoulder Development


References

  1. Malashichev Y, Christ B & Pröls F. (2008). Avian pelvis originates from lateral plate mesoderm and its development requires signals from both ectoderm and paraxial mesoderm. Cell Tissue Res. , 331, 595-604. PMID: 18087724 DOI.
  2. Pillet J. Reconstruction des organes pelviens d’embryons humains de 12,5 et de 25 mm CR. (1967) Ass Anat 51: 819-827.
  3. Pillet J. Reconstruction du pelvis d’un embryon humain de 7.5 mm (Stade XVI de Streeter) CR. (1968) Ass Anat 52: 1013-1023.
  4. Pillet J (1969) Reconstruction des organes génito«-urinaires et des veines pelviennes d’un embryon de 12,5 mm (Stade XVII de Streeter) CR. Ass Anat 53 : 1817-1824.
  5. Pillet J. Reconstruction des organes pelviens d’un embryon de 5 mm (Stade XV de Streeter) CR. (1971) Ass Anat 54:705-715
  6. 6.0 6.1 6.2 Okumura M, Ishikawa A, Aoyama T, Yamada S, Uwabe C, Imai H, Matsuda T, Yoneyama A, Takeda T & Takakuwa T. (2017). Cartilage formation in the pelvic skeleton during the embryonic and early-fetal period. PLoS ONE , 12, e0173852. PMID: 28384153 DOI.
  7. Verbruggen SW & Nowlan NC. (2017). Ontogeny of the Human Pelvis. Anat Rec (Hoboken) , 300, 643-652. PMID: 28297183 DOI.
  8. Giordani J, Bajard L, Demignon J, Daubas P, Buckingham M & Maire P. (2007). Six proteins regulate the activation of Myf5 expression in embryonic mouse limbs. Proc. Natl. Acad. Sci. U.S.A. , 104, 11310-5. PMID: 17592144 DOI.
  9. 9.0 9.1 Geetha-Loganathan P, Nimmagadda S, Christ B, Huang R & Scaal M. (2010). Ectodermal Wnt6 is an early negative regulator of limb chondrogenesis in the chicken embryo. BMC Dev. Biol. , 10, 32. PMID: 20334703 DOI.
  10. Yu SR, Burkhardt M, Nowak M, Ries J, Petrásek Z, Scholpp S, Schwille P & Brand M. (2009). Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules. Nature , 461, 533-6. PMID: 19741606 DOI.
  11. 11.0 11.1 Windhagen H, Thorey F, Kronewid H, Pressel T, Herold D & Stukenborg-Colsman C. (2005). The effect of functional splinting on mild dysplastic hips after walking onset. BMC Pediatr , 5, 17. PMID: 15958160 DOI.
  12. US Preventive Services Task Force. (2006). Screening for developmental dysplasia of the hip: recommendation statement. Pediatrics , 117, 898-902. PMID: 16510673 DOI.


Reviews

Hill RE. (2007). How to make a zone of polarizing activity: insights into limb development via the abnormality preaxial polydactyly. Dev. Growth Differ. , 49, 439-48. PMID: 17661738 DOI.

Articles

Satoh A, Makanae A & Wada N. (2010). The apical ectodermal ridge (AER) can be re-induced by wounding, wnt-2b, and fgf-10 in the chicken limb bud. Dev. Biol. , 342, 157-68. PMID: 20347761 DOI.

Galli A, Robay D, Osterwalder M, Bao X, Bénazet JD, Tariq M, Paro R, Mackem S & Zeller R. (2010). Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development. PLoS Genet. , 6, e1000901. PMID: 20386744 DOI.

Stefanov EK, Ferrage JM, Parchim NF, Lee CE, Reginelli AD, Taché M & Anderson RA. (2009). Modification of the zone of polarizing activity signal by trypsin. Dev. Growth Differ. , 51, 123-33. PMID: 19207183 DOI.

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Cite this page: Hill, M.A. (2018, June 22) Embryology Musculoskeletal System - Pelvis Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Musculoskeletal_System_-_Pelvis_Development

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© Dr Mark Hill 2018, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G