Musculoskeletal System - Pelvis Development
|Embryology - 11 Dec 2018 Expand to Translate|
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- 1 Introduction
- 2 Some Recent Findings
- 3 Textbooks
- 4 Timeline
- 5 Muscle Development (Myogenesis)
- 6 Limb Bone
- 7 Molecular
- 8 Abnormalities
- 9 Shoulder
- 10 References
- 11 Additional Images
- 12 Glossary Links
The pelvis is a developmentally complex skeletal structure requiring the fusion of separate elements and articulation with both the axial skeleton and lower limb. Postnatally, the human upright posture has also placed highly species specific physical demands on this structure. Developmental dysplasia of the hip is also one of the 3 most common (along with cleft palate, cleft lip) skeletal abnormalities.
The skeletal pelvis consists of: the sacrum and coccyx (axial skeleton), and pelvic girdle formed by a pair of hip bones (appendicular skeleton). Before puberty, he pelvic girdle also consists of three unfused bones: the ilium, ischium, and pubis. In chicken, the entire pelvic girdle originates from the somatopleure mesoderm (somite levels 26 to 35) and the ilium, but not of the pubis and ischium, depends on somitic and ectodermal signals.
The mesoderm forms nearly all the connective tissues of the musculoskeletal system. Each tissue (cartilage, bone, and muscle) goes through many different mechanisms of differentiation.
The musculoskeletal system consists of skeletal muscle, bone, and cartilage and is mainly mesoderm in origin with some neural crest contribution.
The intraembryonic mesoderm can be broken into paraxial, intermediate and lateral mesoderm relative to its midline position. During the 3rd week the paraxial mesoderm forms into "balls" of mesoderm paired either side of the neural groove, called somites.
Somites appear bilaterally as pairs at the same time and form earliest at the cranial (rostral,brain) end of the neural groove and add sequentially at the caudal end. This addition occurs so regularly that embryos are staged according to the number of somites that are present. Different regions of the somite differentiate into dermomyotome (dermal and muscle component) and sclerotome (forms vertebral column). An example of a specialized musculoskeletal structure can be seen in the development of the limbs.
Skeletal muscle forms by fusion of mononucleated myoblasts to form mutinucleated myotubes. Bone is formed through a lengthy process involving ossification of a cartilage formed from mesenchyme. Two main forms of ossification occur in different bones, intramembranous (eg skull) and endochondrial (eg limb long bones) ossification. Ossification continues postnatally, through puberty until mid 20s. Early ossification occurs at the ends of long bones.
Thomson A. The sexual differences of the fetal pelvis. (1899) J Anat Physiol. 33(3): 359-380.
Ruth EB. A study of the development of the mammalian pelvis. (1932) Anat. Rec. 53(2): 208 -
Some Recent Findings
|More recent papers|
This table shows an automated computer PubMed search using the listed sub-heading term.
References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.
Search term: Pelvis Embryology
G Mikuz Ectopias of the kidney, urinary tract organs, and male genitalia. [Ektopien der Niere, Harnwege und männlichen Geschlechtsorgane.] Pathologe: 2018; PubMed 30446779
Kenichiro Fukuoka, Joerg Wilting, Jose Francisco Rodríguez-Vázquez, Gen Murakami, Akimitsu Ishizawa, Akio Matsubara The Embryonic Ascent of the Kidney Revisited. Anat Rec (Hoboken): 2018; PubMed 30290083
Jill P J M Hikspoors, Nutmethee Kruepunga, Greet M C Mommen, Jean-Marie P W U Peeters, Cindy J M Hülsman, S Eleonore Köhler, Wouter H Lamers The development of the dorsal mesentery in human embryos and fetuses. Semin. Cell Dev. Biol.: 2018; PubMed 30142441
Y Wang, Q Lin, Z J Sun, B Jiang, B Hou, J J Lu, L Zhu, F Feng, Z Y Jin, J H Lang [Value of MRI in the pre-operative diagnosis and classification of oblique vaginal septum syndrome]. Zhonghua Fu Chan Ke Za Zhi: 2018, 53(8);534-539 PubMed 30138963
G Mikuz [Ectopias of the kidney, urinary tract organs, and male genitalia. German version.] [Ektopien der Niere, Harnwege und männlichen Geschlechtsorgane.] Pathologe: 2018; PubMed 30135974
Louise T S Arenholt, Bodil Ginnerup Pedersen, Karin Glavind, Susanne Greisen, Karl M Bek, Marianne Glavind-Kristensen Prospective evaluation of paravaginal defect repair with and without apical suspension: a 6-month postoperative follow-up with MRI, clinical examination, and questionnaires. Int Urogynecol J: 2018; PubMed 30506182
John R Humm, Narayan Yoganandan, Klaus G Driesslein, Frank A Pintar Three-dimensional kinematic corridors of the head, spine, and pelvis for small female driver seat occupants in near- and far-side oblique frontal impacts. Traffic Inj Prev: 2018;1-6 PubMed 30517033
V Belluscio, E Bergamini, G Salatino, T Marro, P Gentili, M Iosa, D Morelli, G Vannozzi Dynamic balance assessment during gait in children with Down and Prader-Willi syndromes using inertial sensors. Hum Mov Sci: 2018, 63;53-61 PubMed 30503982
Dongxu Liu, Jianfeng Jiang, Yingqi Hua, Zhengdong Cai, Zhongmin Jin, Leiming Gao, Zikai Hua In vitro experimental and numerical study on biomechanics and stability of a novel adjustable hemipelvic prosthesis. J Mech Behav Biomed Mater: 2018, 90;626-634 PubMed 30500700
Abbey C Thompson, Terence D Capellini, Catherine A Guenther, Yingguang Frank Chan, Carlos R Infante, Douglas B Menke, David M Kingsley ##Title## Elife: 2018, 7; PubMed 30499775
- The Developing Human: Clinically Oriented Embryology (8th Edition) by Keith L. Moore and T.V.N Persaud - Moore & Persaud Chapter 15 the skeletal system
- Larsen’s Human Embryology by GC. Schoenwolf, SB. Bleyl, PR. Brauer and PH. Francis-West - Chapter 11 Limb Dev (bone not well covered in this textbook)
- Before we Are Born (5th ed.) Moore and Persaud Chapter 16,17: p379-397, 399-405
- Essentials of Human Embryology Larson Chapter 11 p207-228
|18||chondrification centres of the ilium, ischium, and pubis first appears. Located around the acetabulum and grew radially.|
|20||iliac crest formed while the iliac body's central part remained chondrified.|
|22||Sacroiliac joint forms.|
|22||Iliac body is discoid. The growth rate was greater in the ilium than in the sacrum-coccyx, pubis, and ischium.|
|23||Articulation of the pubic symphysis, connection of the articular column in the sacrum, and Y-shape connection of the three parts of the hip bones to the acetabulum.|
|Early Fetal||connection of the ischium and pubic ramus.|
|Data from human CT and MRI study.|
|Links: pelvis | pelvis timeline | joint | limb | timeline|
Muscle Development (Myogenesis)
- Early myogenic progenitor cells in the dermomyotome can be initially identified by the transcription factor Pax3.
- Subsequent myogenic program development then depends on the myogenic determination factors (Myf5, MyoD, and MRF4), both Myf5 and MyoD are expressed in the limbs.
- Final differentiation of these cells into post-mitotic muscle fibers in the limb bud is regulated by another myogenic determination factor, Myogenin.
(Some of the above text modified from
Links: Muscle Development
Bone formation within the limb occurs by endochondral ossification of a pre-existing cartilage template. Ossification then replaces the existing cartilage except in the regions of articulation, where cartilage remains on the surface of the bone within the joint. Therefore bone development in the limb is initially about cartilage development or chondrogenesis.
In addition, there are two quite separate aspects to this development.
- Pattern - where the specific regions will commence to form cartilage, which will be different for each cartilage element.
- Chondrogenesis - the differentiation of mesoderm to form cartilage, which will be essentially the same program for all cartilage templates.
A recent study has identified that the overlying limb surface ectoderm potentially inhibits limb early chondrogenesis through Wnt6 signaling.
Fibroblast Growth Factors
- Fgf8 - morphogen gradient forms by a source-sink mechanism with freely diffusing molecules.
T-box Transcription Factors
Developmental Dysplasia of the Hip
Developmental dysplasia of the hip ((DDH) or congenital hip dislocation is one of the 3 most common skeletal abnormalities and can range from unilateral or bilateral instability to complete dislocation at the femur acetabulum of the lower limb. See the recommendation statement for screening for developmental dysplasia of the hip.
- Instability: 1:60 at birth; 1:240 at 1 wk: Dislocation untreated; 1:700
- congenital instability of hip, later dislocates by muscle pulls or gravity
- familial predisposition female predominance
- Growth of femoral head, acetabulum and innominate bone are delayed until the femoral head fits firmly into the acetabulum.
International Classification of Diseases
- Q65.0 Congenital dislocation of hip, unilateral
- Q65.1 Congenital dislocation of hip, bilateral
- Q65.2 Congenital dislocation of hip, unspecified
- Q65.3 Congenital subluxation of hip, unilateral
- Q65.4 Congenital subluxation of hip, bilateral
- Q65.5 Congenital subluxation of hip, unspecified
- Q65.6 Unstable hip Dislocatable hip Subluxatable hip
- Q65.8 Other congenital deformities of hip Anteversion of femoral neck Congenital acetabular dysplasia Congenital coxa: valga vara
- Q65.9 Congenital deformity of hip, unspecified
(Barlow maneuver) A clinical term to describe a physical examination of the newborn for Developmental dysplasia of the hip (DDH). The examiner adducts the hip (bringing the thigh towards the midline) while applying light pressure on the knee, directing the force posteriorly. A positive sign is the hip being dislocatable, if the hip can be popped out of socket with this test. This test is then combined with the Ortolani test (manoeuvre). The test is named after Thomas Barlow (1845 – 1945) a British royal physician.
(Ortolani manoeuvre) A clinical term to describe a physical examination of the newborn for developmental dysplasia of the hip (DDH). This is a test for posterior dislocation of the hip. Using the examiner's thumb, abduct the infant's leg, while using the examiner's index finger to place anterior pressure on the greater trochanter. A positive sign is a distinctive 'clunk' which can be heard and felt as the femoral head relocates anteriorly into the acetabulum, usually becomes negative after 2 months of age. This test is combined with the Barlow test (maneuver). Named after Marino Ortolani, the test developer in 1976.
There is variable evidence for the use of abduction splinting during onset of walking in children on the maturation of mild dysplastic hips.
The skeletal shoulder consists of: the clavicle (collarbone), the scapula (shoulder blade), and the humerus. Development of his region occurs through both forms of ossification processes.
- Links: Shoulder Development
- Malashichev Y, Christ B & Pröls F. (2008). Avian pelvis originates from lateral plate mesoderm and its development requires signals from both ectoderm and paraxial mesoderm. Cell Tissue Res. , 331, 595-604. PMID: 18087724 DOI.
- Pillet J. Reconstruction des organes pelviens d’embryons humains de 12,5 et de 25 mm CR. (1967) Ass Anat 51: 819-827.
- Pillet J. Reconstruction du pelvis d’un embryon humain de 7.5 mm (Stade XVI de Streeter) CR. (1968) Ass Anat 52: 1013-1023.
- Pillet J (1969) Reconstruction des organes génito«-urinaires et des veines pelviennes d’un embryon de 12,5 mm (Stade XVII de Streeter) CR. Ass Anat 53 : 1817-1824.
- Pillet J. Reconstruction des organes pelviens d’un embryon de 5 mm (Stade XV de Streeter) CR. (1971) Ass Anat 54:705-715
- Okumura M, Ishikawa A, Aoyama T, Yamada S, Uwabe C, Imai H, Matsuda T, Yoneyama A, Takeda T & Takakuwa T. (2017). Cartilage formation in the pelvic skeleton during the embryonic and early-fetal period. PLoS ONE , 12, e0173852. PMID: 28384153 DOI.
- Verbruggen SW & Nowlan NC. (2017). Ontogeny of the Human Pelvis. Anat Rec (Hoboken) , 300, 643-652. PMID: 28297183 DOI.
- Giordani J, Bajard L, Demignon J, Daubas P, Buckingham M & Maire P. (2007). Six proteins regulate the activation of Myf5 expression in embryonic mouse limbs. Proc. Natl. Acad. Sci. U.S.A. , 104, 11310-5. PMID: 17592144 DOI.
- Geetha-Loganathan P, Nimmagadda S, Christ B, Huang R & Scaal M. (2010). Ectodermal Wnt6 is an early negative regulator of limb chondrogenesis in the chicken embryo. BMC Dev. Biol. , 10, 32. PMID: 20334703 DOI.
- Yu SR, Burkhardt M, Nowak M, Ries J, Petrásek Z, Scholpp S, Schwille P & Brand M. (2009). Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules. Nature , 461, 533-6. PMID: 19741606 DOI.
- Windhagen H, Thorey F, Kronewid H, Pressel T, Herold D & Stukenborg-Colsman C. (2005). The effect of functional splinting on mild dysplastic hips after walking onset. BMC Pediatr , 5, 17. PMID: 15958160 DOI.
- US Preventive Services Task Force. (2006). Screening for developmental dysplasia of the hip: recommendation statement. Pediatrics , 117, 898-902. PMID: 16510673 DOI.
Galli A, Robay D, Osterwalder M, Bao X, Bénazet JD, Tariq M, Paro R, Mackem S & Zeller R. (2010). Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development. PLoS Genet. , 6, e1000901. PMID: 20386744 DOI.
Stefanov EK, Ferrage JM, Parchim NF, Lee CE, Reginelli AD, Taché M & Anderson RA. (2009). Modification of the zone of polarizing activity signal by trypsin. Dev. Growth Differ. , 51, 123-33. PMID: 19207183 DOI.
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Cite this page: Hill, M.A. (2018, December 11) Embryology Musculoskeletal System - Pelvis Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Musculoskeletal_System_-_Pelvis_Development
- © Dr Mark Hill 2018, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G