2017 Group Project 3

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2017 Student Projects 
Student Projects: 1 Cerebral Cortex | 2 Kidney | 3 Heart | 4 Eye | 5 Lung | 6 Cerebellum
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Heart

Mark Hill (talk) 16:06, 14 September 2017 (AEST) OK Feedback

  • This is very early stage of content development. Of all the possible topics this is definitely the MOST researched topic to date. You have this week to make significant progress on this page.
  • Where is the timeline of development.
  • Where is the timeline of key discoveries
  • Splanchnic mesoderm and neural crest contribution
  • Differentiation of different cardiac cell types
  • Cardiac conduction system development
  • Cardiomyocyte differentiation/function
  • Cardiac stem cells

Introduction

The cardiovascular system is the first system to develop and function in the human embryo. The rapid cardiac development is essential as the growing embryo can no longer receive oxygen and essential nutrients via diffusion alone, hence a circulatory system and a contractile heart mechanism is required to supply the embryo. We recognise the hearts normal development is vital for foetal life, and hence we have chosen to document the development of the heart from gastrulation to birth. Any defects occurring during the developmental processes can lead to congenital heart abnormalities. However, early cardiac development is a multifaceted procedure and is associated with other developmental processes such as: embryonic folding, coelom formation, and vascular development [1].

Through researching the advances in technology, coupled with the biological use of suitable animal models [2] our understanding of embryological cardiac development has evolved, and we are piecing together the mechanism underlying this development. This page will outline the importance of how heart abnormalities arise, the treatments available and the possible treatments to be developed in the future. Due to the major knowledge gaps in current embryological heart research, we acknowledge that this will impact our assignment, and aim to address further research concepts that will improve our understanding.

Antoon Moorman, Sandra Webb, Nigel A Brown, Wouter Lamers, Robert H Anderson Development of the heart: (1) formation of the cardiac chambers and arterial trunks. Heart: 2003, 89(7);806-14 PubMed 12807866


Z5076019 (talk)

Developmental Origin

Development of Trilaminar Embryonic Disc .png


In the developing embryo the lateral plate mesoderm splits into somatic and splanchnic layers, the latter is comprised of cardiac progenitor cells [3]. The somatic mesoderm lines the ectoderm, the splanchnic mesoderm lines the endoderm, and in between lies an embryonic coelom [4] . At the end of week three, the heart develops from splanchnic mesoderm of the cardiogenic region of the embryonic plate. At the cranial end of the embryo, anterior to the developing neural tube is the initial origin of heart formation.

Morphology of Heart Tube Formation- Student Image .png

Originally, as seen in figure 2 the cardiogenic region forms laterally of the paraxial mesoderm and primitive streak of the embryonic disc. Due to the natural mesenchymal cell organisation of the mesoderm, cells ‘migrate’ and fuse at the midline of the cranial end of the embryo forming the cardiac crescent just prior cardiac tube formation and folding. As in figure 2, endoderm surrounding the primitive gut contracts, and brings the cardiogenic precursor regions of the splanchnic region towards the midline. At this time, early heart formation occurs in the form of angioblastic cords of the splanchnic mesoderm. The angioblastic cords develop into separate endochondral heart tubes moving closer together as the foregut pinches together and the yolk sac contracts into the embryo. Fusion of the two heart tubes is facilitated by apoptosis [5] . The origin of the primitive heart is in the early pericardial coelom, which is later developed into the pericardial cavity, through fusion of the pleuropericardial folds to separate the pleural cavities at the later development of the lungs (see figure 4) [6].


Heart Tube Fusion Model of Early Development.png Pericardial Development 4-6 Gestation weeks .jpg


Gert van den Berg, Antoon F M Moorman Concepts of cardiac development in retrospect. Pediatr Cardiol: 2009, 30(5);580-7 PubMed 19184179


Chi Wan Koo, Adrienne Newburg Congenital Absence of the Right Pericardium: Embryology and Imaging. J Clin Imaging Sci: 2015, 5;12 PubMed 25861546


[7] Antoon Moorman, Sandra Webb, Nigel A Brown, Wouter Lamers, Robert H Anderson Development of the heart: (1) formation of the cardiac chambers and arterial trunks. Heart: 2003, 89(7);806-14 PubMed 12807866

[8] Gert van den Berg, Antoon F M Moorman Concepts of cardiac development in retrospect. Pediatr Cardiol: 2009, 30(5);580-7 PubMed 19184179


Z5076019 (talk) 14:19, 26 August 2017

Developmental Timeline

Embryonic Developmental Timeline

Primary Heart Field and Heart Tube Formation

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1767747/

Secondary Heart Field and Cardiac Looping

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1767747/

Cardiac Neural crest and Outflow tract

Atrial and Ventricular Septation

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1767797/

Proepicardium and Coronary Heart Development

MAIN ARTICLE --> http://www.springer.com/cda/content/document/cda_downloaddocument/9781588294432-c2.pdf?SGWID=0-0-45-387660-p173728389 http://www.nature.com/pr/journal/v57/n2/full/pr200525a.html?foxtrotcallback=true



Historic Developmental Timeline

[9]

[10]

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Developmental Signalling Processes

Heart development is a very complicated and dynamic process that requires a high degree of control and regulation. This control is achieved by different molecular pathways expressed at different stages of heart development.

Wnt signalling

Both canonical and non-canonical Wnt signalling pathways have a role in different stages of cardiac development. These two pathways may have an overlapping role in in cardiac development or they may work independent. The canonical Wnt signalling pathway involves β-catenin and is activated by a number of ligands such as Wnt-1, Wnt-2, Wnt-3A, Wnt-8A, Wnt-8B, Wnt-8C, Wnt-10A, and Wnt-10B. However, the non-canonical signalling pathway is associated with planar cell polarity and Wnt/Ca2+ pathways that are activated by different ligands such as Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A, Wnt7B, and Wnt11 [1].

Transforming growth factor β

File:Fig2.jpg
Canonical Wnt/β-Catenin signaling and non-canonical Wnt signaling pathways[2]


Mark Hill (talk) 15:57, 31 August 2017 (AEST) OK this image requires a better descriptive name than "Fig2.jpg"


[11]

[12]

[13]

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Current Research And Findings

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[| Effect of maternal position on fetal behavioural state and heart rate variability in healthy late gestation pregnancy]

[| Acidic fibroblast growth factor and heart development. Role in myocyte proliferation and capillary angiogenesis]

[|The Role of Na+/Ca2+ Exchanger 1 in Maintaining Ductus Arteriosus Patency]


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Animal Models

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Abnormal Development

Ventricular Septal Defect

[14]

[15] - ventricular septal defect (Penny and Vick)

Atrial Septal Defect

[16] - atrial septal defects (Giva, Martins & Wald)

Atrioventricular Septal Defect

Misc. References

[17]

[18]


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Future Questions

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Glossary of Terms

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References

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  • Abhirath Parikh, Jincheng Wu, Robert M Blanton, Emmanuel S Tzanakakis Signaling Pathways and Gene Regulatory Networks in Cardiomyocyte Differentiation. Tissue Eng Part B Rev: 2015, 21(4);377-92 PubMed 25813860
  • Wenrui Liu, Ann C Foley Signaling pathways in early cardiac development. Wiley Interdiscip Rev Syst Biol Med: 2010, 3(2);191-205 PubMed 20830688