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'''Summary''' | '''Summary''' | ||
According to this study, vitamin D may play a role in human reproduction. Therefore, the aim of this study was to find out whether there is a correlation between vitamin D levels and implantation and clinical pregnancy rates in infertile women following IVF. | According to this study, vitamin D may play a role in human reproduction. Therefore, the aim of this study was to find out whether there is a correlation between vitamin D levels and implantation and clinical pregnancy rates in infertile women following IVF. | ||
'''Method''' | '''Method''' | ||
• Total of 173 infertile women participated in the study that met the following criteria: aged 18-41 years, follicle stimulating hormone level 12 IU/L or lower and able to provide informed consent. | • Total of 173 infertile women participated in the study that met the following criteria: aged 18-41 years, follicle stimulating hormone level 12 IU/L or lower and able to provide informed consent. | ||
• 25(OH)D samples were collected within 1 week before oocyte retrieval from those infertile women. | • 25(OH)D samples were collected within 1 week before oocyte retrieval from those infertile women. | ||
• Vitamin D status was evaluated and determined by serum 25-hydroxy-vitamin D (25[OH]D) levels. | • Vitamin D status was evaluated and determined by serum 25-hydroxy-vitamin D (25[OH]D) levels. | ||
• Patients were classified in two different groups; having sufficient (≥ 75 nmol/L) or insufficient (or deficient; hereafter referred to as “insufficient”; < 75 nmol/L) serum levels of 25(OH)D. | • Patients were classified in two different groups; having sufficient (≥ 75 nmol/L) or insufficient (or deficient; hereafter referred to as “insufficient”; < 75 nmol/L) serum levels of 25(OH)D. | ||
• Patient demographics and IVF cycle parameters between two groups were compared. | • Patient demographics and IVF cycle parameters between two groups were compared. | ||
• Clinical pregnancy, as identified by ultrasound following 4-5 weeks after embryo transfer; was the primary outcome measurement. | • Clinical pregnancy, as identified by ultrasound following 4-5 weeks after embryo transfer; was the primary outcome measurement. | ||
'''Findings''' | '''Findings''' | ||
According to the outcome of this study, the women with sufficient levels of 25(OH)D had significantly higher rates of clinical pregnancy (52.5%) per IVF cycle started than that with insufficient levels (34.7%). Therefore, Vitamin D supplementation can potentially provide an easy and cost-effective way of improving pregnancy rates but requires further investigations as the results are not statistically significant in the sufficient 25(OH)D group | |||
According to the outcome of this study, the women with sufficient levels of 25(OH)D had significantly higher rates of clinical pregnancy (52.5%) per IVF cycle started than that with insufficient levels (34.7%). Therefore, Vitamin D supplementation can potentially provide an easy and cost-effective way of improving pregnancy rates but requires further investigations as the results are not statistically significant in the sufficient 25(OH)D group. | |||
Revision as of 11:11, 8 August 2015
Lab Attendance
--Z3463890 (talk) 13:46, 7 August 2015 (AEST)
Lab Assessment 1
Article 1
"Effect of vitamin D status on clinical pregnancy rates following in vitro fertilization" [1] PMID 25077107
Summary
According to this study, vitamin D may play a role in human reproduction. Therefore, the aim of this study was to find out whether there is a correlation between vitamin D levels and implantation and clinical pregnancy rates in infertile women following IVF.
Method
• Total of 173 infertile women participated in the study that met the following criteria: aged 18-41 years, follicle stimulating hormone level 12 IU/L or lower and able to provide informed consent.
• 25(OH)D samples were collected within 1 week before oocyte retrieval from those infertile women.
• Vitamin D status was evaluated and determined by serum 25-hydroxy-vitamin D (25[OH]D) levels.
• Patients were classified in two different groups; having sufficient (≥ 75 nmol/L) or insufficient (or deficient; hereafter referred to as “insufficient”; < 75 nmol/L) serum levels of 25(OH)D.
• Patient demographics and IVF cycle parameters between two groups were compared.
• Clinical pregnancy, as identified by ultrasound following 4-5 weeks after embryo transfer; was the primary outcome measurement.
Findings
According to the outcome of this study, the women with sufficient levels of 25(OH)D had significantly higher rates of clinical pregnancy (52.5%) per IVF cycle started than that with insufficient levels (34.7%). Therefore, Vitamin D supplementation can potentially provide an easy and cost-effective way of improving pregnancy rates but requires further investigations as the results are not statistically significant in the sufficient 25(OH)D group.
References
- ↑ <pubmed>25077107</pubmed>
References
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- 2015 Course: Week 2 Lecture 1 Lecture 2 Lab 1 | Week 3 Lecture 3 Lecture 4 Lab 2 | Week 4 Lecture 5 Lecture 6 Lab 3 | Week 5 Lecture 7 Lecture 8 Lab 4 | Week 6 Lecture 9 Lecture 10 Lab 5 | Week 7 Lecture 11 Lecture 12 Lab 6 | Week 8 Lecture 13 Lecture 14 Lab 7 | Week 9 Lecture 15 Lecture 16 Lab 8 | Week 10 Lecture 17 Lecture 18 Lab 9 | Week 11 Lecture 19 Lecture 20 Lab 10 | Week 12 Lecture 21 Lecture 22 Lab 11 | Week 13 Lecture 23 Lecture 24 Lab 12 | 2015 Projects: Three Person Embryos | Ovarian Hyper-stimulation Syndrome | Polycystic Ovarian Syndrome | Male Infertility | Oncofertility | Preimplantation Genetic Diagnosis | Students | Student Designed Quiz Questions | Moodle page
