User:Z3416054: Difference between revisions

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Hi there Just giving the editor a good old test run. Test student 2015

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--Z3416054 (talk) 13:45, 7 August 2015 (AEST) --Mark Hill (talk) 10:47, 6 August 2015 (AEST) Thanks for setting up your page. We will be talking more about this in the Practical on Friday.

Lab 1 Assessment

Article 1

This research article aimed to determine the clinical outcomes following IVF (in vitro fertilisation) and embryo transfer treatments in subjects suffering from the sexually transmitted disease syphilis. The clinical outcomes mentioned are the rates of pregnancy and health of newborns following treatment via IVF. Couples engaged in sexual intercourse over 12 months without the use of contraception and who failed to conceive were deemed as being infertile.

The subjects were divided into two groups based on serology results, a syphilis infected group and a control group, each with 160 individuals, giving a total of 320 subjects. The Syphilis infected group was further divided into three subcategories, a male infected group, a female infected group and a couple (male and female) infected group. Penicillin G20 (an anti-syphilis treatment) was given to the individuals in the syphilis group. IVF treatment commenced one month proceeding the disappearance of clinical syphilis symptoms or if test results gave a negative result for syphilis infection.

The results of this experiment revealed no significant differences in regards to the basal FSH and LH of both the control and syphilis groups. However, the thickness of the endometrium differed greatly, with the syphilis group demonstrating a thicker endometrial wall (16.9±5.4mm) compared to the control group (13.0±4.7mm). Further differences were noted in blastocyst implantation rates, with the syphilis group having less successful implantations compared to the control (24.2% vs. 34.4% respectively).Normal oocyte cleavage differed between the two groups with the syphilis group demonstrating less normal oocyte cleavage compared to the control group (6.3±4.7 vs. 8.1±4.6). Furthermore, the clinical pregnancy rates of the syphilis group stood at 43.8% compared to 55.6% of the control group.

Syphilis infection appeared to have a significant impact on the success and clinical outcomes of IVF. Syphilis associated pelvic inflammatory disease can lead to an increase in the thickness of the endometrium, which can adversely affect blastocyte implantation and endometrial receptivity. Successful pregnancy rates typically correlate with an endometrial thickness of 7-14mm, with any thickness beyond 14mm often corresponding with decreased clinical pregnancies. Rates of clinical pregnancy and miscarriage rates did not differ between the three syphilis subgroups. Conception involving a male infected partner was associated with a shorter gestational period and decreased offspring birth weight, when compared to the female infected and couple infected subgroups. No explanation for this phenomenon was provided.

PMID 26208116

Article 1 Reference: <pubmed>PMC4514756</pubmed>

Article 2

The effects of oxygen levels on factors such as cleavage, implantation and pregnancy rates in IVF generated embryos was the primary focus of this article.

PMID 26131222

Article 2 Reference: <pubmed>PMC4483955</pubmed>

References

PMID 26244658

Look at this!<ref><pubmed>26244658</pubmed>

@@ Line 23: / Line 23: @@
 <pubmed>PMC4514756</pubmed>
 ===Article 2===
+The effects of oxygen levels on factors such as cleavage, implantation and pregnancy rates in IVF generated embryos was the primary focus of this article.
 PMID 26131222