|Embryology - 29 May 2020 Expand to Translate|
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|A personal message from Dr Mark Hill (May 2020)|
|contributors to the site. The good news is Embryology will remain online and I will continue my association with UNSW Australia. I look forward to updating and including the many exciting new discoveries in Embryology!|
- 1 Introduction
- 2 Some Recent Findings
- 3 Pharyngeal Arch Contributions
- 4 Embryonic
- 5 Fetal
- 6 Tongue Muscles
- 7 Tongue Innervation
- 8 Lingual Frenulum
- 9 Histology
- 10 Abnormalities
- 11 Additional Images
- 12 References
- 13 External Links
- 14 Glossary Links
The tongue's embryonic orgin is derived from all pharyngeal arches contributing different components. As the tongue (Latin, lingua; Greek, glossa) develops "inside" the floor of the oral cavity, it is not readily visible in the external views of the embryonic (Carnegie) stages of development. Tongue muscle cells originate from somites mesoderm, while muscles of mastication derive from the unsegmented somitomeres. This current page gives a brief overview of early tongue development.
The dorsal tongue is covered by a stratified squamous epithelium, with numerous papillae and taste buds. There are also 8 to 12 circumvallate papillae arranged in an inverted V-shape towards the base of the tongue. These notes cover development of the muscular tongue, not the sense of taste.
|Taste Links: Introduction | Student project | Tongue Development | Category:Taste|
|Historic Embryology - Tongue|
|1902 Tongue | 1917 von Ebner's glands | 1921 Tongue|
Some Recent Findings
|More recent papers|
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
|These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.
Pharyngeal Arch Contributions
The tongue has contributions from all pharyngeal arches which changes with time. The tongue initially begins as swelling rostral to foramen cecum, the median tongue bud.
Animation shows the sequence of development of the tongue. The different colours represents the relative contribution from each pharyngeal arch.
Human embryonic tongue development (mid-sagittal section)
These histology images are from the Carnegie Stage 22 human embryo.
Carnegie Stage 23 oral cavity floor
|Carnegie Stage 23 oral cavity floor|
|Section shows detail of the tongue muscular structure, formed from occipital somites.
The genioglossus (fan-shaped muscle) lies between the tongue and mandible and is innervated by the hypoglossal nerve (CN XII). Poking out your tongue is a test of this nerve. Note the tongue connective tissue and vasculature are derived from neural crest.
Week 12 - 24
The following measurements of fetal tongue circumference show linear growth during the second trimester and are based upon multiple (2-10) separate ultrasound measurements.
|Table data Tongue circumference measured by transvaginal ultrasonography between 14 and 17 GA weeks, and by abdominal ultrasound between 18 and 26 GA weeks of gestation.|
Links: tongue | fetal | ultrasound
- Tongue muscles originate from the somites.
- Masticatory muscles (MM) originate from the somitomeres. These muscles develop late and are not complete even at birth.
- Tongue muscles develop before masticatory muscles and complete by birth.
Developing muscle fibers within the tongue. Note the multinucleated appearance of each muscle fiber and their overall organization. Muscle goes through the same developmental changes as other skeletal muscle.
See also: Embryonic and postnatal development of masticatory and tongue muscles.
- Links: Skeletal Muscle Histology
The tongue is innervated by a range of cranial nerve connections related to muscles, oral mucosa, taste buds, and minor salivary glands.
- trigeminal nerve (CN V) - lingual branch
- facial nerve (CN VII) - chorda tympani branch
- glossopharyngeal nerve (CN IX)
- hypoglossal nerve (CN XII) - motor components of innervated muscles.
The hypoglossal nerve (CN CN XII) provides the motor innervation of the intrinsic and extrinsic tongue muscles allowing protrusion, retrusion, and changes in the shape of the tongue. Motor units within the hypoglossal motor system can be categorized as predominantly fast fatigue resistant.
The human tongue innervation has been recently analysed histologically and described as extremely dense and complex. The structure of the motor endplate junctions (neuromuscular junctions) was found to be of the multiple en grappe (grapelike cluster) form. The transverse muscle group that comprises the core of the tongue was found to have the most complex innervation. The pattern of innervation of the human tongue also has specializations not found in other mammalian tongues, this allows for fine motor control of tongue shape.
The pathway of the hypoglossal nerve can be imaged using magnetic imaging (MRI) while computer tomography (CT) can show the bony anatomy of the neurovascular foramina of the skull base. Clinically, the nerve pathway can be divided into three regions: intra-axial, cisternal, skull base and extracranial segments.
- Links: Cranial Nerve Development
Frenulum is a general term for a small fold of integument (skin) or mucous membrane that limits the movements of an organ or part. There are several anatomical frenula associated with the genital system, while the lingual frenulum is associated with the inferior side of the tongue.
The lingual frenulum length (short) and position of insertion (anterior) can lead to speech disorders and may affect postnatal feeding. Interestingly, it is the prevalence of pain in mothers breastfeeding infants with ankyloglossia that presents many problems in breastfeeding.
Children with a frenulum length of more than 2 cm do not show these speech problems. Ankyloglossia (tongue-tie) is the general clinical term for the short frenulum which limits the range of movement of the tongue, there is still no accurate classification for this condition. Frenotomy, frenectomy, and frenuloplasty are the main surgical treatment options to release or remove an ankyloglossia.
Term means an abnormally large tongue. Macroglossia is more common than microglossia and can be associated with a number of genetic abnormalities including: trisomy 21 (Down syndrome), acromegaly, Beckwith-Wiedemann syndrome, mucopolysaccharidoses and primary amyloidosis. There is also an association with congenital hypothyroidism and diabetes.
Macroglossia associated with Beckwith-Wiedemann syndrome.
Term means an abnormally small tongue. A recent study has identified cranial neural crest fibroblasts non-canonical transforming growth factor β (TGFβ) regulation of FGF and BMP signalling can cause similar tongue muscle developmental defects.
Ankyloglossia (tongue-tie) is the general clinical term for the short lingual frenulum (less than 2 cm), that limits the range of movement of the tongue, prevalence ranges between 4.2% and 10.7%. This is associated with speech development disorders and has been suggested as also associated with feeding disorders. There is still no accurate classification for this condition. Frenotomy, frenectomy, and frenuloplasty are the main surgical treatment options to release or remove an ankyloglossia, though there is still discussion about surgical intervention.
A short lingual frenulum is also associated with a number of genetic syndromes such as: ROR2-Related Robinow Syndrome, Dystrophic Epidermolysis Bullosa, Oral-Facial-Digital Syndrome Type I, Opitz Syndrome (X-Linked Opitz G/BBB Syndrome) and Van der Woude syndrome.
- Links: Medline Plus - Tongue tie | ROR2-Related Robinow Syndrome | Dystrophic Epidermolysis Bullosa | Oral-Facial-Digital Syndrome Type I | X-Linked Opitz G/BBB Syndrome
|Historic Disclaimer - information about historic embryology pages|
|Embryology History | Historic Embryology Papers)|
Human Embryology and Morphology. Keith, A. (1902) London: Edward Arnold.
Anatomy of the Human Gray, H. (1918) Philadelphia: Lea & Febiger.
- Okuhara S, Birjandi AA, Adel Al-Lami H, Sagai T, Amano T, Shiroishi T, Xavier GM, Liu KJ, Cobourne MT & Iseki S. (2019). Temporospatial sonic hedgehog signalling is essential for neural crest-dependent patterning of the intrinsic tongue musculature. Development , 146, . PMID: 31719045 DOI.
- Castillo-Azofeifa D, Seidel K, Gross L, Golden EJ, Jacquez B, Klein OD & Barlow LA. (2018). SOX2 regulation by hedgehog signaling controls adult lingual epithelium homeostasis. Development , 145, . PMID: 29945863 DOI.
- Cobourne MT, Iseki S, Birjandi AA, Adel Al-Lami H, Thauvin-Robinet C, Xavier GM & Liu KJ. (2018). How to make a tongue: Cellular and molecular regulation of muscle and connective tissue formation during mammalian tongue development. Semin. Cell Dev. Biol. , , . PMID: 29784581 DOI.
- Zhu XJ, Yuan X, Wang M, Fang Y, Liu Y, Zhang X, Yang X, Li Y, Li J, Li F, Dai ZM, Qiu M, Zhang Z & Zhang Z. (2017). A Wnt/Notch/Pax7 signaling network supports tissue integrity in tongue development. J. Biol. Chem. , 292, 9409-9419. PMID: 28438836 DOI.
- Iwata J, Suzuki A, Pelikan RC, Ho TV & Chai Y. (2013). Noncanonical transforming growth factor β (TGFβ) signaling in cranial neural crest cells causes tongue muscle developmental defects. J. Biol. Chem. , 288, 29760-70. PMID: 23950180 DOI.
- Song Z, Liu C, Iwata J, Gu S, Suzuki A, Sun C, He W, Shu R, Li L, Chai Y & Chen Y. (2013). Mice with Tak1 deficiency in neural crest lineage exhibit cleft palate associated with abnormal tongue development. J. Biol. Chem. , 288, 10440-50. PMID: 23460641 DOI.
- Aoyama K, Yamane A, Suga T, Suzuki E, Fukui T & Nakamura Y. (2011). Bone morphogenetic protein-2 functions as a negative regulator in the differentiation of myoblasts, but not as an inducer for the formations of cartilage and bone in mouse embryonic tongue. BMC Dev. Biol. , 11, 44. PMID: 21736745 DOI.
- Kim JY, Lee MJ, Cho KW, Lee JM, Kim YJ, Kim JY, Jung HI, Cho JY, Cho SW & Jung HS. (2009). Shh and ROCK1 modulate the dynamic epithelial morphogenesis in circumvallate papilla development. Dev. Biol. , 325, 273-80. PMID: 19014928 DOI.
- Hong SJ, Cha BG, Kim YS, Lee SK & Chi JG. (2015). Tongue Growth during Prenatal Development in Korean Fetuses and Embryos. J Pathol Transl Med , 49, 497-510. PMID: 26471340 DOI.
- Achiron R, Ben Arie A, Gabbay U, Mashiach S, Rotstein Z & Lipitz S. (1997). Development of the fetal tongue between 14 and 26 weeks of gestation: in utero ultrasonographic measurements. Ultrasound Obstet Gynecol , 9, 39-41. PMID: 9060129 DOI.
- Yamane A. (2005). Embryonic and postnatal development of masticatory and tongue muscles. Cell Tissue Res. , 322, 183-9. PMID: 16041600 DOI.
- Smith JC, Goldberg SJ & Shall MS. (2005). Phenotype and contractile properties of mammalian tongue muscles innervated by the hypoglossal nerve. Respir Physiol Neurobiol , 147, 253-62. PMID: 16087149 DOI.
- Mu L & Sanders I. (2010). Human tongue neuroanatomy: Nerve supply and motor endplates. Clin Anat , 23, 777-91. PMID: 20607833 DOI.
- Alves P. (2010). Imaging the hypoglossal nerve. Eur J Radiol , 74, 368-77. PMID: 20347541 DOI.
- Queiroz Marchesan I. (2004). Lingual frenulum: classification and speech interference. Int J Orofacial Myology , 30, 31-8. PMID: 15832860
- Segal LM, Stephenson R, Dawes M & Feldman P. (2007). Prevalence, diagnosis, and treatment of ankyloglossia: methodologic review. Can Fam Physician , 53, 1027-33. PMID: 17872781
- Suter VG & Bornstein MM. (2009). Ankyloglossia: facts and myths in diagnosis and treatment. J. Periodontol. , 80, 1204-19. PMID: 19656020 DOI.
Cobourne MT, Iseki S, Birjandi AA, Adel Al-Lami H, Thauvin-Robinet C, Xavier GM & Liu KJ. (2018). How to make a tongue: Cellular and molecular regulation of muscle and connective tissue formation during mammalian tongue development. Semin. Cell Dev. Biol. , , . PMID: 29784581 DOI.
Achiron R, Ben Arie A, Gabbay U, Mashiach S, Rotstein Z & Lipitz S. (1997). Development of the fetal tongue between 14 and 26 weeks of gestation: in utero ultrasonographic measurements. Ultrasound Obstet Gynecol , 9, 39-41. PMID: 9060129 DOI.
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Cite this page: Hill, M.A. (2020, May 29) Embryology Tongue Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Tongue_Development
- © Dr Mark Hill 2020, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G