Granulosa cell: Difference between revisions
mNo edit summary |
mNo edit summary |
||
Line 53: | Line 53: | ||
! Corpus Luteum Granulosa cells | ! Corpus Luteum Granulosa cells | ||
|- | |- | ||
| [[File:Ovary | | [[File:Ovary histology 006.jpg|400px]] | ||
| [[File:Corpus luteum lutein cells.jpg|300px]] | | [[File:Corpus luteum lutein cells.jpg|300px]] | ||
|} | |} |
Revision as of 10:28, 12 November 2014
Embryology - 9 May 2024 Expand to Translate |
---|
Google Translate - select your language from the list shown below (this will open a new external page) |
العربية | català | 中文 | 中國傳統的 | français | Deutsche | עִברִית | हिंदी | bahasa Indonesia | italiano | 日本語 | 한국어 | မြန်မာ | Pilipino | Polskie | português | ਪੰਜਾਬੀ ਦੇ | Română | русский | Español | Swahili | Svensk | ไทย | Türkçe | اردو | ייִדיש | Tiếng Việt These external translations are automated and may not be accurate. (More? About Translations) |
Introduction
Surrounding the oocyte as it develops within the ovary follicle are multiple layers of granulosa cells that are bound to the thick specialised extracellular matrix, the zona pellucida. Following release of the oocyte at ovulation, these cells form the granolas layer.
Granulosa cells can also have specific names depending upon location within the ovarian follicle: cumulus oophrous (Latin, cumulus = a little mound; Greek, oo= egg, phorus = carrying) granulosa cells directly around the zone pellucida and released with the oocyte; membrana granulosa granulosa cells forming the layer within the follicle antral wall; discus proligerus can refer to the attachment between cumulus oophrous and membrane granulosa; and mural granulosa cells that line the follicular wall.
In human development, during the first week of development following fertilization the granolas cell layer and zona pellucida remains surrounding the blastocyst from which it "hatches" to commence implantation.
Some Recent Findings
|
More recent papers |
---|
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Granulosa cell development <pubmed limit=5>Granulosa cell development</pubmed> |
Follicle Granulosa Cells
Granulosa cells can also have specific names depending upon location within the follicle.
|
Cumulus Granulosa Cells
<pubmed limit=5>Cumulus Granulosa development</pubmed>
Mural Granulosa Cells
Mural Granulosa Cells (MGCs) lining the ovulating follicle remain within the ovary and differentiate to form part of the corpus luteum.
Steroid hormone synthesis by mural granulosa cells is dependent upon the multiligand receptor LOX-1.[4]
Mural Granulosa Cells | Corpus Luteum Granulosa cells |
---|---|
Search PubMed term: Mural Granulosa development
<pubmed limit=5>Mural Granulosa development</pubmed>
- Links: Corpus luteum
Mouse Granulosa Cells
Molecular
- Lhcgr - LH-receptor, a marker of mural granulosa cells.
- Slc38a3 - amino acid transporter, a marker of cumulus granulosa cells.
- HAS2, PTGS2, PTX3, TNFAIP6
- BMP15, GDF9, FGF8
Abnormalities
Granulosa cell tumour
An uncommon non-epithelial cancer of the ovary.
Photograph of a granulosa cell tumour[5]
References
- ↑ <pubmed>25144310</pubmed>| PLoS One.
- ↑ <pubmed>25376232</pubmed>
- ↑ <pubmed>24009315</pubmed>
- ↑ <pubmed>24710763</pubmed>
- ↑ <pubmed>21060767</pubmed>| PMC2974967 | Case Rep Oncol
Reviews
<pubmed></pubmed> <pubmed></pubmed> <pubmed>15271471</pubmed> <pubmed>14967918</pubmed>
Articles
<pubmed></pubmed> <pubmed></pubmed> <pubmed>24422759</pubmed> <pubmed>24270888</pubmed> <pubmed>12077402</pubmed>
Search Pubmed
Search Pubmed: granulosa cell
Search Images: granulosa cell
Search NCBI Bookshelf Granulosa cell
Additional Images
Cat oocyte zona pellucida spermatozoa bound SEM
Hamster oocyte zona pellucida SEM
Pig ZPC deposition in oocyte-cumulus complexes
Terms
- acrosome reaction - The chemical change within the spermatozoa following binding to the zona pellucida, that leads to the release of acrosomal enzymatic contents. These enzymes degrade the zona pellucida and allow a spermatozoa to penetrate an oocyte.
- cumulus cell - (Latin, cumulus = a little mound; Greek, oo= egg, phorus=carrying) granulosa cells directly around the zone pellucida a
- granulosa cell - A specific cell type that proliferates in association with the oocyte within the developing follicles of the ovary. These cells form the follicle stratum granulosa and are also given specific names based upon their position within the follicle. In the antral follicle, membrana granulosa sits on the follicular basal lamina and lines the antrum as a stratified epithelium. The cumulus oophorus is a column of granulosa cells that attaches the oocyte to the follicle wall. The corona radiata are the granulosa cells that directly surround the oocyte, and are released along with it at ovulation. Following ovulation the corona radiata provide physical protection to the oocyte and granulosa cells within the ovulating follicle contribute to corpus luteum.
- mural granulosa cell - (MGC) granulosa cells that line the follicular wall and have an endocrine function.
External Links
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2024, May 9) Embryology Granulosa cell. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Granulosa_cell
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G