Book - Liver development
|Embryology - 5 Dec 2020 Expand to Translate|
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Aaron M. Zorn
Division of Developmental Biology, Cincinnati Children’s Research Foundation, Cincinnati, Ohio 45229-3039, USA
The liver is the largest internal organ and it provides many essential metabolic, exocrine and endocrine functions. Hepatocytes are the principal cell type in the liver and these along with biliary epithelial cells are derived from the embryonic endoderm. Embryological experiments in animal models have demonstrated that liver development occurs through a progressive series of reciprocal tissue interactions between the embryonic endoderm and nearby mesoderm. In the last ten years many of the genes and molecular pathways that regulate hepatogenesis have been identified. Recently application of this knowledge has enabled researchers to produce “hepatic-like” tissue from embryonic stem (ES) cells in vitro, which may ultimately lead to therapeutically useful tissue for transplantation. This review summarizes the current understanding of the molecular pathways controlling liver and biliary system development focusing on studies in the mouse embryo where this process is best understood.
Full chapter - Liver Development (2008) PDF
Fig.1. Liver cell lineage. The cell lineage steps during hepatic development (red) from uncommitted endoderm to functional adult hepatocytes and biliary epithelium.
2008 Aaron M. Zorn. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Cite this page: Hill, M.A. (2020, December 5) Embryology Book - Liver development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Book_-_Liver_development
- © Dr Mark Hill 2020, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G