Book - Liver development

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Zorn AM. (2008). Liver development. , , . PMID: 20614624 DOI. | online extract | PDF

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This 2008 online book chapter by Zorn describes the development of the liver.


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Liver Development

Aaron M. Zorn

Division of Developmental Biology, Cincinnati Children’s Research Foundation, Cincinnati, Ohio 45229-3039, USA

Abstract

The liver is the largest internal organ and it provides many essential metabolic, exocrine and endocrine functions. Hepatocytes are the principal cell type in the liver and these along with biliary epithelial cells are derived from the embryonic endoderm. Embryological experiments in animal models have demonstrated that liver development occurs through a progressive series of reciprocal tissue interactions between the embryonic endoderm and nearby mesoderm. In the last ten years many of the genes and molecular pathways that regulate hepatogenesis have been identified. Recently application of this knowledge has enabled researchers to produce “hepatic-like” tissue from embryonic stem (ES) cells in vitro, which may ultimately lead to therapeutically useful tissue for transplantation. This review summarizes the current understanding of the molecular pathways controlling liver and biliary system development focusing on studies in the mouse embryo where this process is best understood.


Full chapter - Liver Development (2008) PDF


Zorn2008 fig01.jpg

Fig.1. Liver cell lineage. The cell lineage steps during hepatic development (red) from uncommitted endoderm to functional adult hepatocytes and biliary epithelium.


Reference

Zorn AM. (2008). Liver development. , , . PMID: 20614624 DOI. | online extract | PDF

Copyright

2008 Aaron M. Zorn. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cite this page: Hill, M.A. (2018, December 10) Embryology Book - Liver development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Book_-_Liver_development

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