AACP Meeting 2013 - Face Embryology: Difference between revisions
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| Stage 13 embryo (week 5) showing otocyst that will form the inner ear. | | Stage 13 embryo (week 5) showing otocyst that will form the inner ear. | ||
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'''left''' Ventrolateral view of the whole embryo with 5-mm scale bar. At this stage of development no middle or external ear structures are apparent and will be derived later from pharyngeal arches one and two (labeled). The gray bar through the head indicates the plane of cross-section (right). | '''left''' Ventrolateral view of the whole embryo with 5-mm scale bar. At this stage of development no middle or external ear structures are apparent and will be derived later from pharyngeal arches one and two (labeled). The gray bar through the head indicates the plane of cross-section (right). | ||
'''right''' A cross-section of the head showing the size and position of the otic vesicles. At this stage of development they lie within the head mesenchyme behind pharyngeal arch one and two and in close apposition to the developing hindbrain. Note the close position of the otic vesicle to the rhombomeres, hindbrain folds that represent the initial segmentation of the hindbrain. Also shown are developing cranial ganglia and blood vessel lying adjacent to the otic vesicles. The wall of the otic vesicle at this stage is a simple epithelium. | '''right''' A cross-section of the head showing the size and position of the otic vesicles. At this stage of development they lie within the head mesenchyme behind pharyngeal arch one and two and in close apposition to the developing hindbrain. Note the close position of the otic vesicle to the rhombomeres, hindbrain folds that represent the initial segmentation of the hindbrain. Also shown are developing cranial ganglia and blood vessel lying adjacent to the otic vesicles. The wall of the otic vesicle at this stage is a simple epithelium. | ||
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| Stage 22 embryo (week 8) showing the embryo near the end of the embryonic period. | | Stage 22 embryo (week 8) showing the embryo near the end of the embryonic period. | ||
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'''A.''' Lateral view of the whole embryo with 5 mm scale bar. Note the well developed external ear with simplified adult structure and narrower meatal opening. The grey bar through the head indicates the plane of cross-section for (B) and (C). | '''A.''' Lateral view of the whole embryo with 5 mm scale bar. Note the well developed external ear with simplified adult structure and narrower meatal opening. The grey bar through the head indicates the plane of cross-section for (B) and (C). | ||
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'''C.''' The gray box indicates this region: detail of inner and middle ear development. The middle ear cavity has not yet formed and the ossicles (malleus shown) are embedded in mesenchyme that is being lost. The tensor tympani muscle is differentiating in the adjacent mesenchyme. The inner ear membranous labyrinth has formed its adult external structure. The section through the turns of the cochlear duct shows the internal cochlea structure is still underdeveloped; in contrast, the balance region is more developed. | '''C.''' The gray box indicates this region: detail of inner and middle ear development. The middle ear cavity has not yet formed and the ossicles (malleus shown) are embedded in mesenchyme that is being lost. The tensor tympani muscle is differentiating in the adjacent mesenchyme. The inner ear membranous labyrinth has formed its adult external structure. The section through the turns of the cochlear duct shows the internal cochlea structure is still underdeveloped; in contrast, the balance region is more developed. | ||
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===External Ear=== | ===External Ear=== |
Revision as of 18:18, 17 May 2013
Face Embryology
2013 Australian Chapter, American Academy of Craniofacial Pain (AACP) Meeting May 18 May 2013
Draft Page - notice removed when complete.
Introduction
This page will be updated and contain the final conference presentation.
<mediaplayer width='420' height='500' image="http://embryology.med.unsw.edu.au/embryology/images/3/33/Face_001_icon.jpg">file:Face_001.mp4</mediaplayer> |
Development of the Face This animation shows a ventral view of development of the human face from approximately week 5 through to neonate. The separate embryonic components that contribute to the face have been colour coded.
The stomodeum is the primordial mouth region and a surface central depression lying between the forebrain bulge and the heart bulge. At the floor of the stomodeum indentation is the buccopharyngeal membrane (oral membrane). Note the complex origin of the maxillary region (upper jaw) requiring the fusion of several embryonic elements, abnormalities of this process lead to cleft lip and cleft palate.
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Key Concepts
Buccopharyngeal Membrane
These images of the Stage 11 embryo show the breakdown of the buccopharyngeal membrane.
The Pharynx
The cavity within the pharyngeal arches forms the pharynx.
- begins at the buccopharyngeal membrane (oral membrane), apposition of ectoderm with endoderm (no mesoderm between)
- expands behind pharyngeal arches
- narrows at glottis and bifurcation of gastrointestinal (oesophagus) and respiratory (trachea) systems
- regions on roof, walls and floor have important contributions to endocrine in oral and neck regions
- also contributes to tongue development
Pharyngeal Arches
Major features to identify for each: arch, pouch, groove and membrane. Contribute to the formation of head and neck and in the human appear at the 4th week. The first arch contributes the majority of upper and lower jaw structures.
- branchial arch (Greek. branchia = gill)
- arch consists of all 3 trilaminar embryo layers
- ectoderm- outside and neural crest
- mesoderm - core of mesenchyme
- endoderm - inside
Neural Crest
- Mesenchyme invaded by neural crest generating connective tissue components
- cartilage, bone, ligaments
- arises from midbrain and hindbrain region
<mediaplayer width='410' height='340' image="http://embryology.med.unsw.edu.au/embryology/images/7/7d/Chicken-neural-crest-migration-01.jpg">File:Chicken-neural crest migration 01.mp4</mediaplayer>
This movie shows individual labelled neural crest cells migrating into the pharyngeal arches in the chicken. |
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Arch Cartilages
Meckel's cartilage - located within the first pharyngeal arch mandibular prominence, forms a cartilage "template" besides which the mandible develops by the process of intramembranous ossification. It is important to note that this cartilage template does not ossify (endochondral ossification) but provides a transient structure where the mandible will form, and later degenerates.
Week 3
Gestational Age (GA week 5)
These images of the Stage 11 embryo show the breakdown of the buccopharyngeal membrane.
Week 4 to 5
Gestational Age (GA week 6 to 7)
Begins week 4 centered around stomodeum, external depression at oral membrane
5 initial primordia from neural crest mesenchyme (week 4)
- single frontonasal prominence (FNP) - forms forehead, nose dorsum and apex
- nasal placodes develop later bilateral, pushed medially
- paired maxillary prominences - form upper cheek and upper lip
- paired mandibular prominences - lower cheek, chin and lower lip
Week 6 to 7
Gestational Age (GA week 8 to 9)
<mediaplayer width='320' height='420' image="http://embryology.med.unsw.edu.au/embryology/images/9/9c/Stage16-18_face_02.jpg">File:Stage16to18 face 01.mp4</mediaplayer> |
Movie shows a quick animation of the ventral views of the human embryo face, between Carnegie stage 16 to stage 18 (Week 6 to Week 7). Animation based on Kyoto embryos.
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Week 5 to 8
Gestational Age (GA week 7 to 10)
<mediaplayer width='380' height='400' image="http://embryology.med.unsw.edu.au/embryology/images/9/92/Stage15to22_head_icon.jpg">File:Stage15to22 head 01.mp4</mediaplayer> |
Movie shows a quick animation of the lateral view of the human embryo head, between Carnegie stage 15 to stage 22 (Week 5 to Week 8). Note that these stage images are not to scale.
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Week 9
Gestational Age (GA week 11)
Secondary Palate Development
<mediaplayer width='350' height='350' image="http://embryology.med.unsw.edu.au/embryology/images/4/4f/Palate_001_icon.jpg">File:Palate_001.mp4</mediaplayer> |
Animation shows an inferior view of the developmental sequence of secondary palate formation. The lower jaw has been removed and the view shows the roof of the oral cavity and the maxilla (upper jaw) and lip.
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<mediaplayer width='350' height='350' image="http://embryology.med.unsw.edu.au/embryology/images/a/a3/Palate_002_icon.jpg">File:Palate_002.mp4</mediaplayer> |
Animation shows an anterior view of the developmental sequence of secondary palate formation. The frontal region of the head has been removed to show the changes within the oral cavity. Secondary palate formation is the growth of the palatal shelves towards the midline, from top to bottom:
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Week 12
Gestational Age (GA week 14)
- 12 Week Images: Sagittal unlabeled | Sagittal labeled | Sagittal medial view | Sagittal lateral view | Pituitary unlabeled | Pituitary labeled | Tongue | Skull Development | Head Development
Week 14
Gestational Age (GA week 16)
Growth of Head Structures
Maxilla
- First pharyngeal arch - upper maxillary (pair) and lower mandibular prominences
- Late embryonic period - maxillary prominences fuse with frontonasal prominence forming upper jaw (maxilla and upper lip)
- EM Links: Image - stage 16 | Image - stage 17 | Image - stage 18 | Image - stage 19 | Palate Development
Temporal Bone and Mandible
Image shows growth of both bones from the end of the embryonic period (week 8) through the fetal period of development (to 9 months).
Inner Ear
External Ear
Images of the lateral view of the human embryonic head from week 5 (stage 14) through to week 8 (stage 23) showing development of the auricular hillocks that will form the external ear.
The adult ear is also shown indicating the part of the ear that each hillock contributes.
Images are not to scale.
Fetal Head Growth
Neonatal Skull
These computed tomography (CT) scans of the normal neonatal skull are shown as as 3D surface-rendered reconstructions.
Abnormalities
Skull
Abnormal Neonatal Skull (CT) | ||
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Dolichocephaly and Scaphocephaly |
Coronal Synostosis |
Anterior Plagiocephaly |
Turricephaly |
300px
Posterior Plagiocephaly |
Deformational Plagiocepahly |
Trigonocephaly |
Oxycephaly |
- Skull CT Images: Normal overview | Normal vertex and lateral | Normal endocranial and vertex | Normal Vertex - Fontanels | Dolichocephaly and Scaphocephaly | Coronal Synostosis | Anterior Plagiocephaly | Turricephaly | Posterior Plagiocephaly | Deformational Plagiocepahly | Trigonocephaly | Oxycephaly | Computed Tomography
Movies
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Histology
Medial view | Lateral view |
Related Pages
Head Links: Introduction | Medicine Lecture | Medicine Lab | Science Lecture | Lecture Movie | Science Lab | pharyngeal arch | Craniofacial Seminar | mouth | palate | tongue | placode | skull | neural crest | Head and Face Movies | head abnormalities | Category:Head | ||
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Historic
1910 Manual of Human Embryology
Franz Keibel, Franklin P. Mall. (1910) - The The Skull, Hyoid Bone, and Larynx
1920 Contributions to Embryology Carnegie Institution No.39
Warren H. Lewis (1920) The Cartilaginous Skull Of A Human Embryo Twenty-One Millimeters In Length
1921 Contributions to Embryology Carnegie Institution No.48
Charles C. Macklin (1921) The skull of a human fetus of 43 millimeters greatest length
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2024, May 1) Embryology AACP Meeting 2013 - Face Embryology. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/AACP_Meeting_2013_-_Face_Embryology
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G