2017 Group Project 3

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Revision as of 17:45, 14 September 2017 by Z5178463 (talk | contribs) (Developmental Timeline)
2017 Student Projects 
Student Projects: 1 Cerebral Cortex | 2 Kidney | 3 Heart | 4 Eye | 5 Lung | 6 Cerebellum
Student Page - here is the sample page I demonstrated with in the first labs.I remind all students that you have your own Group Forum on Moodle for your discussions, it is only accessible by members of your group.
Editing Links: Editing Basics | Images | Tables | Referencing | Journal Searches | Copyright | Font Colours | Virtual Slide Permalink | My Preferences | One Page Wiki Card | Printing | Movies | Language Translation | Student Movies | Using OpenOffice | Internet Browsers | Moodle | Navigation/Contribution | Term Link | Short URLs | 2018 Test Student

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Mark Hill (talk) 16:06, 14 September 2017 (AEST) OK Feedback

  • This is very early stage of content development. Of all the possible topics this is definitely the MOST researched topic to date. You have this week to make significant progress on this page.
  • Where is the timeline of development.
  • Where is the timeline of key discoveries
  • Splanchnic mesoderm and neural crest contribution
  • Differentiation of different cardiac cell types
  • Cardiac conduction system development
  • Cardiomyocyte differentiation/function
  • Cardiac stem cells


The cardiovascular system is the first system to develop and function in the human embryo, and at week four of prenatal development, the heart begins to beat. At the beginning of stage nine (middle of week three) we see the functional folding of the neural plate and development of the neural tube give rise to the differentiation of the germ layers into products that eventually form the fully functional embryonic heart. Advances in technology, ‘coupled with the use of suitable animal models’ has allowed the evolution of our understanding of embryological cardiac developmental, and allows us to observe how it has stemmed from the more “classical accounts”.

The cardiovascular system is the first system to develop and function in the human embryo. Its normal development is vital for fetal life and any defects occurring in its developmental processes can lead to continental heart abnormalities. Advances in technology, ‘coupled with the use of suitable animal models’ has allowed the evolution of our understanding of embryological cardiac developmental and the mechanism underlying this development. This knowledge assists our understanding of how heart abnormalities arise and the possible treatments to be developed in the future.

<pubmed> PMC1767747</pubmed>




Developmental Origin

Pericardial Development 4-6 Gestation weeks .jpg

PubMed Searches:

[2] <pubmed>PMC1767747</pubmed>




Z5076019 (talk) 14:19, 26 August 2017

Developmental Timeline

Embryonic Developmental Timeline

week 2-3 - precardiac cells in primitive streak, bilateral cardiogenic areas form, mesoderm splitting, heart tube fusion week 4-5 - neural crest migration starts, dorsal and ventral endocardial cushions fused, foramen closes, septum secundum begins to develop week 6-7 - bulbular ridges and trabeculations evident, aortic and pulmonary trunks cleave, valves furthur developed, SA node identifiable

Historic Developmental Timeline




Developmental Signalling Processes

Heart development is a very complicated and dynamic process that requires a high degree of control and regulation. This control is achieved by different molecular pathways expressed at different stages of heart development.

Wnt signalling

Both canonical and non-canonical Wnt signalling pathways have a role in different stages of cardiac development. These two pathways may have an overlapping role in in cardiac development or they may work independent. The canonical Wnt signalling pathway involves β-catenin and is activated by a number of ligands such as Wnt-1, Wnt-2, Wnt-3A, Wnt-8A, Wnt-8B, Wnt-8C, Wnt-10A, and Wnt-10B. However, the non-canonical signalling pathway is associated with planar cell polarity and Wnt/Ca2+ pathways that are activated by different ligands such as Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A, Wnt7B, and Wnt11 [1].

Transforming growth factor β

Canonical Wnt/β-Catenin signaling and non-canonical Wnt signaling pathways[2]

Mark Hill (talk) 15:57, 31 August 2017 (AEST) OK this image requires a better descriptive name than "Fig2.jpg"





Current Research And Findings

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[| Effect of maternal position on fetal behavioural state and heart rate variability in healthy late gestation pregnancy]

[| Acidic fibroblast growth factor and heart development. Role in myocyte proliferation and capillary angiogenesis]

[|The Role of Na+/Ca2+ Exchanger 1 in Maintaining Ductus Arteriosus Patency]

Z5018962 (talk)z5018962Z5018962 (talk)

Animal Models


Abnormal Development

Ventricular Septal Defect


[12] - ventricular septal defect (Penny and Vick)

Atrial Septal Defect

[13] - atrial septal defects (Giva, Martins & Wald)

Atrioventricular Septal Defect

Misc. References




Future Questions


Glossary of Terms

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  • <pubmed>25813860</pubmed>
  • <pubmed>20830688</pubmed>