Neural Crest - Cardiac: Difference between revisions
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* '''Review - The Cardiac Neural Crest Cells in Heart Development and Congenital Heart Defects'''{{#pmid:34436231|PMID34436231}} "The neural crest (NC) is a multipotent and temporarily migratory cell population stemming from the dorsal neural tube during vertebrate embryogenesis. Cardiac neural crest cells (NCCs), a specified subpopulation of the NC, are vital for normal cardiovascular development, as they significantly contribute to the pharyngeal arch arteries, the developing cardiac outflow tract (OFT), cardiac valves, and interventricular septum. Various signaling pathways are shown to orchestrate the proper migration, compaction, and differentiation of cardiac NCCs during cardiovascular development. Any loss or dysregulation of signaling pathways in cardiac NCCs can lead to abnormal cardiovascular development during embryogenesis, resulting in abnormalities categorized as congenital heart defects (CHDs). This review focuses on the contributions of cardiac NCCs to cardiovascular formation, discusses cardiac defects caused by a disruption of various regulatory factors, and summarizes the role of multiple signaling pathways during embryonic development. A better understanding of the cardiac NC and its vast regulatory network will provide a deeper insight into the mechanisms of the associated abnormalities, leading to potential therapeutic advancements." | |||
* '''Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion'''{{#pmid:30376688|PMID30376688}} "Proper development of the great vessels of the heart and septation of the cardiac outflow tract requires cardiac neural crest cells. These cells give rise to the parasympathetic cardiac ganglia, the smooth muscle layer of the great vessels, some cardiomyocytes, and the conotruncal cushions and aorticopulmonary septum of the outflow tract. Ablation of cardiac neural crest cells results in defective patterning of each of these structures. Previous studies have shown that targeted deletion of the forkhead transcription factor C2 ([https://www.omim.org/entry/602402 Foxc2]), results in cardiac phenotypes similar to that derived from cardiac neural crest cell ablation. We report that Foxc2-/- embryos on the 129s6/SvEv inbred genetic background display persistent truncus arteriosus and hypoplastic ventricles before embryonic lethality. Foxc2 loss-of-function resulted in perturbed cardiac neural crest cell migration and their reduced contribution to the outflow tract as evidenced by lineage tracing analyses together with perturbed expression of the neural crest cell markers Sox10 and Crabp1. Foxc2 loss-of-function also resulted in alterations in PlexinD1, Twist1, PECAM1, and Hand1/2 expression in association with vascular and ventricular defects." {{heart}} | [https://www.omim.org/entry/602402 Foxc2] | * '''Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion'''{{#pmid:30376688|PMID30376688}} "Proper development of the great vessels of the heart and septation of the cardiac outflow tract requires cardiac neural crest cells. These cells give rise to the parasympathetic cardiac ganglia, the smooth muscle layer of the great vessels, some cardiomyocytes, and the conotruncal cushions and aorticopulmonary septum of the outflow tract. Ablation of cardiac neural crest cells results in defective patterning of each of these structures. Previous studies have shown that targeted deletion of the forkhead transcription factor C2 ([https://www.omim.org/entry/602402 Foxc2]), results in cardiac phenotypes similar to that derived from cardiac neural crest cell ablation. We report that Foxc2-/- embryos on the 129s6/SvEv inbred genetic background display persistent truncus arteriosus and hypoplastic ventricles before embryonic lethality. Foxc2 loss-of-function resulted in perturbed cardiac neural crest cell migration and their reduced contribution to the outflow tract as evidenced by lineage tracing analyses together with perturbed expression of the neural crest cell markers Sox10 and Crabp1. Foxc2 loss-of-function also resulted in alterations in PlexinD1, Twist1, PECAM1, and Hand1/2 expression in association with vascular and ventricular defects." {{heart}} | [https://www.omim.org/entry/602402 Foxc2] | ||
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===Cardiac Neural Crest=== | ===Cardiac Neural Crest=== | ||
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===Reviews=== | ===Reviews=== | ||
{{#pmid:34436231}} | |||
{{#pmid:25662261}} | {{#pmid:25662261}} |
Latest revision as of 13:15, 23 February 2022
Embryology - 14 Jun 2024 Expand to Translate |
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Introduction
Draft Page (notice removed when completed).
Cardiac neural crest has an important contribution to the developing heart outflow tract.[1] It has been shown to not contribute to any of the heart conduction system.[2]
Neural Crest Links: neural crest | Lecture - Early Neural | Lecture - Neural Crest Development | Lecture Movie | Schwann cell | adrenal | melanocyte | peripheral nervous system | enteric nervous system | cornea | cranial nerve neural crest | head | skull | cardiac neural crest | Nicole Le Douarin | Neural Crest Movies | neural crest abnormalities | Category:Neural Crest | |||
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Cardiovascular System Development
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Cardiac Neural Crest <pubmed limit=5>Cardiac Crest</pubmed> |
Older papers |
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These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.
See also the Discussion Page for other references listed by year and References on this current page. |
Cardiac Neural Crest
References
- ↑ Creazzo TL, Godt RE, Leatherbury L, Conway SJ & Kirby ML. (1998). Role of cardiac neural crest cells in cardiovascular development. Annu. Rev. Physiol. , 60, 267-86. PMID: 9558464 DOI.
- ↑ Boullin J & Morgan JM. (2005). The development of cardiac rhythm. Heart , 91, 874-5. PMID: 15958352 DOI.
- ↑ Erhardt S, Zheng M, Zhao X, Le TP, Findley TO & Wang J. (2021). The Cardiac Neural Crest Cells in Heart Development and Congenital Heart Defects. J Cardiovasc Dev Dis , 8, . PMID: 34436231 DOI.
- ↑ Inman KE, Caiaffa CD, Melton KR, Sandell LL, Achilleos A, Kume T & Trainor PA. (2018). Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion. Dev. Dyn. , 247, 1286-1296. PMID: 30376688 DOI.
- ↑ Rosa AL, Alvarez ME, Lawson D & Maccioni HJ. (1990). A polypeptide of 59 kDa is associated with bundles of cytoplasmic filaments in Neurospora crassa. Biochem. J. , 268, 649-55. PMID: 2141976
Reviews
Erhardt S, Zheng M, Zhao X, Le TP, Findley TO & Wang J. (2021). The Cardiac Neural Crest Cells in Heart Development and Congenital Heart Defects. J Cardiovasc Dev Dis , 8, . PMID: 34436231 DOI.
Plein A, Fantin A & Ruhrberg C. (2015). Neural crest cells in cardiovascular development. Curr. Top. Dev. Biol. , 111, 183-200. PMID: 25662261 DOI.
Keyte AL, Alonzo-Johnsen M & Hutson MR. (2014). Evolutionary and developmental origins of the cardiac neural crest: building a divided outflow tract. Birth Defects Res. C Embryo Today , 102, 309-23. PMID: 25227322 DOI.
Creazzo TL, Godt RE, Leatherbury L, Conway SJ & Kirby ML. (1998). Role of cardiac neural crest cells in cardiovascular development. Annu. Rev. Physiol. , 60, 267-86. PMID: 9558464 DOI.
Articles
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Cite this page: Hill, M.A. (2024, June 14) Embryology Neural Crest - Cardiac. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Neural_Crest_-_Cardiac
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G