Neural Crest - Cardiac

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Cardiac Neural Crest Migration
Cardiac Neural Crest Migration

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Cardiac neural crest has an important contribution to the developing heart outflow tract.[1] It has been shown to not contribute to any of the heart conduction system.[2]

Neural Crest Links: neural crest | Lecture - Early Neural | Lecture - Neural Crest Development | Lecture Movie | Schwann cell | adrenal | melanocyte | peripheral nervous system | enteric nervous system | cornea | cranial nerve neural crest | head | skull | cardiac neural crest | Nicole Le Douarin | Neural Crest Movies | neural crest abnormalities | Category:Neural Crest
Historic Embryology - Neural Crest  
1879 Olfactory Organ | 1905 Cranial and Spinal Nerves | 1908 10 mm Peripheral | 1910 Mammal Sympathetic | 1920 Human Sympathetic | 1928 Cranial ganglia | 1939 10 Somite Embryo | 1942 Origin | 1957 Adrenal

Cardiovascular System Development

Some Recent Findings

  • Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion[3] "Proper development of the great vessels of the heart and septation of the cardiac outflow tract requires cardiac neural crest cells. These cells give rise to the parasympathetic cardiac ganglia, the smooth muscle layer of the great vessels, some cardiomyocytes, and the conotruncal cushions and aorticopulmonary septum of the outflow tract. Ablation of cardiac neural crest cells results in defective patterning of each of these structures. Previous studies have shown that targeted deletion of the forkhead transcription factor C2 (Foxc2), results in cardiac phenotypes similar to that derived from cardiac neural crest cell ablation. We report that Foxc2-/- embryos on the 129s6/SvEv inbred genetic background display persistent truncus arteriosus and hypoplastic ventricles before embryonic lethality. Foxc2 loss-of-function resulted in perturbed cardiac neural crest cell migration and their reduced contribution to the outflow tract as evidenced by lineage tracing analyses together with perturbed expression of the neural crest cell markers Sox10 and Crabp1. Foxc2 loss-of-function also resulted in alterations in PlexinD1, Twist1, PECAM1, and Hand1/2 expression in association with vascular and ventricular defects." heart | Foxc2
  • FGF8 signaling is chemotactic for cardiac neural crest cells[4] "neural crest cells migrate into the pharyngeal arches where they support development of the pharyngeal arch arteries. The pharyngeal endoderm and ectoderm both express high levels of FGF8. We hypothesized that FGF8 is chemotactic for cardiac crest cells. To begin testing this hypothesis, cardiac crest was explanted for migration assays under various conditions. Cardiac neural crest cells migrated more in response to FGF8."
More recent papers  
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Search term: Cardiac Neural Crest

<pubmed limit=5>Cardiac Crest</pubmed>

Older papers  
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Cardiac Neural Crest

<pubmed limit=5>Cardiac Neural Crest</pubmed>


  1. Creazzo TL, Godt RE, Leatherbury L, Conway SJ & Kirby ML. (1998). Role of cardiac neural crest cells in cardiovascular development. Annu. Rev. Physiol. , 60, 267-86. PMID: 9558464 DOI.
  2. Boullin J & Morgan JM. (2005). The development of cardiac rhythm. Heart , 91, 874-5. PMID: 15958352 DOI.
  3. Inman KE, Caiaffa CD, Melton KR, Sandell LL, Achilleos A, Kume T & Trainor PA. (2018). Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion. Dev. Dyn. , 247, 1286-1296. PMID: 30376688 DOI.
  4. Rosa AL, Alvarez ME, Lawson D & Maccioni HJ. (1990). A polypeptide of 59 kDa is associated with bundles of cytoplasmic filaments in Neurospora crassa. Biochem. J. , 268, 649-55. PMID: 2141976


Plein A, Fantin A & Ruhrberg C. (2015). Neural crest cells in cardiovascular development. Curr. Top. Dev. Biol. , 111, 183-200. PMID: 25662261 DOI.

Keyte AL, Alonzo-Johnsen M & Hutson MR. (2014). Evolutionary and developmental origins of the cardiac neural crest: building a divided outflow tract. Birth Defects Res. C Embryo Today , 102, 309-23. PMID: 25227322 DOI.

Creazzo TL, Godt RE, Leatherbury L, Conway SJ & Kirby ML. (1998). Role of cardiac neural crest cells in cardiovascular development. Annu. Rev. Physiol. , 60, 267-86. PMID: 9558464 DOI.


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Cite this page: Hill, M.A. (2021, July 27) Embryology Neural Crest - Cardiac. Retrieved from

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