2017 Group Project 5: Difference between revisions
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Surfactant - where cells are derived from (macrophages, type 1 and type 2 pneumocytes) | Surfactant - where cells are derived from (macrophages, type 1 and type 2 pneumocytes) | ||
Lungs become fully developed within the mother, however they do not function until birth. | Lungs become fully developed within the mother, however they do not function until birth. | ||
At the end of the conducting system, are sac-like structures known as alveoli, which are assist in gas in exchange. Alveoli are lined by two types of cells, squamous alveolar type 1 cells and cuboidal ... | |||
==Current understandings and areas of research== | ==Current understandings and areas of research== |
Revision as of 12:12, 9 September 2017
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Lungs
An introduction to the lungs...
On this page, we will be exploring the development of the lungs through the stages of embryonic growth.
Lung Anatomy
Lung Histology
Developmental origin overview
Brief overview of development of lung
More detailed overview in lung development stages
The Respiratory Zone
The Terminal Bronchioles
Alveolar ducts
Alveoli
The Conducting Zone
The Lung Development Stages
Developmental timeline
Developmental signalling processes
Chemicals involved in the development of lungs. Growth factors that contribute to branching of lungs - SHH and fibroblast growth factor as well as any other hormones or factors that are relevant to lung development
The development of a mammalian lung is a multi-step and highly complex process involving signalling pathways.
Several growth factors and chemical signals have been identified to influence lung development. These signalling molecules include:
1. Fibroblast Growth Factor (FGF10) - serves as a signalling cue for epithelium outgrowth in the mesenchyme.
2. Sonic Hedgehog (SHH) - produced in the epitheliumand is involved in regulating FGF10 expression, leading to the intertubular mesenchyme to facilitate growth and formation of epithelial buds.
3. Heparan Sulfate Glycosaminoglycans (HS-GAG) - interacts with SHH in order to produce epthelial cells and lung morphogenesis. There is still a lack of understanding in the role that HS plays in mammalian lung development.
The conducting system
Branching of lungs Different types of branching - domain branching, planar bifurcation, trifurcation, orthogonal bifurcation.
The mammalian lung develops through branching morphogenesis.
Alveolus: the functional unit
How the alveoli work. Cell types Maturation and development Surfactant - where cells are derived from (macrophages, type 1 and type 2 pneumocytes) Lungs become fully developed within the mother, however they do not function until birth.
At the end of the conducting system, are sac-like structures known as alveoli, which are assist in gas in exchange. Alveoli are lined by two types of cells, squamous alveolar type 1 cells and cuboidal ...
Current understandings and areas of research
include any relevant articles
Review and research articles
Movies
Animal models
Abnormal development
Premature Birth
Lobar Emphysema
Congenital Diaphragmatic Hernia
Azygos lobe
Meconium Aspiration Syndrome
Newborn Respiratory Distress Syndrome
Surfactant Metabolism
Bronchopulmonary Dysplasia
Lung Agenesis
Cystic Fibrosis
CHAOS (Congenital High Airway Obstruction Syndrome)
CPAM (Congenital Pulmonary Airway Malformation)
Lung Cardiovasculature
Future questions
Glossary
References
- ↑ Gilbert SF. Developmental Biology. 6th edition. Sunderland (MA): Sinauer Associates; 2000. Comparative Embryology. Available from: https://www.ncbi.nlm.nih.gov/books/NBK9974/