BGDB Practical - Sexual Differentiation: Difference between revisions
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This practical will introduce the topic of sexual differentiation during development through a series of online resource pages. | This practical will introduce the topic of sexual differentiation during development through a series of online resource pages. | ||
'''Aim:''' This practical is an introduction to the earliest events in Sexual Differentiation. | '''Aim:''' This practical is an introduction to the earliest events in Sexual Differentiation. | ||
'''Key Concepts:''' | |||
'''Key Concepts:''' {{primordial germ cell}}, sex chromosomes, gonad, internal genitalia, external genitalia, {{ovary}}, {{testis}}, {{puberty}}, hormonal changes, gametogenesis, {{genital abnormalities}} ({{DSD}}). | |||
==Background== | ==Background== | ||
{| | {| | ||
| [[File:Historic-testis.jpg| | | [[File:Historic-testis.jpg|140px]] | ||
[[File:Historic-ovary.jpg|200px]] | [[File:Historic-ovary.jpg|200px]] | ||
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The endpoint of development could be considered the post-puberty active reproductive system. Interestingly, recent research is pointing to a link between neural and reproductive systems in how male and female brains may differentially develop under the influence of sex hormones and perhaps even the sex chromosomes. | The endpoint of development could be considered the post-puberty active reproductive system. Interestingly, recent research is pointing to a link between neural and reproductive systems in how male and female brains may differentially develop under the influence of sex hormones and perhaps even the sex chromosomes. | ||
* There are 6 pages to work through in today's practical class, listed beside the small BGD icon at the top and bottom of each page. | * There are 6 pages to work through in today's practical class, listed beside the small BGD icon at the top and bottom of each page. | ||
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==Genital Timeline== | ==Genital Timeline== | ||
''These are approximate timings and stages only.'' | |||
24 days - intermediate mesoderm, pronephros primordium | * [[Carnegie stage 11|24 days]] - intermediate mesoderm, pronephros primordium | ||
* [[Carnegie stage 13|28 days]] - mesonephros and mesonephric duct | |||
* [[Carnegie stage 15|35 days]] - uteric bud, metanephros, urogenital ridge | |||
* [[Carnegie stage 17|42 days]] - cloacal divison, gonadal primordium (indifferent) | |||
* [[Carnegie stage 19|49 days]] - paramesonephric duct, gonadal differentiation | |||
* [[Carnegie stage 23|56 days]] - paramesonephric duct fusion (female) | |||
* 100 days - primary follicles (ovary) | |||
* postnatal 2 months of age - male primordial germ cells (gonocytes) are replaced by adult dark (Ad) and pale (Ap) spermatogonia forming the spermatogonial stem cell (SSC) population. | |||
==Textbooks== | |||
{| | |||
! Textbooks | |||
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| [[File:Logo.png|alt=Embryo logo|80px]] | |||
| {{Embryo citation}} | |||
{{Genital Links}} | |||
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| [[File:The Developing Human, 10th edn.jpg|90px]] | |||
| {{MPT2015APAcitation}} (links only function with UNSW connection) | |||
Chapter 12 [http://www.unsw.eblib.com.wwwproxy0.library.unsw.edu.au/patron/Read.aspx?p=2074364&pg=329 Urogenital System] | |||
|- | |||
| [[File:Larsen's human embryology 5th ed.jpg|90px]] | |||
| {{Larsen2015APAcitation}}(links only function with UNSW connection) | |||
Chapter 15 [http://www.unsw.eblib.com.wwwproxy0.library.unsw.edu.au/patron/Read.aspx?p=2074524&pg=393 Development of the Urinary System] | |||
Chapter 16 [http://www.unsw.eblib.com.wwwproxy0.library.unsw.edu.au/patron/Read.aspx?p=2074524&pg=412 Development of the Reproductive System] | |||
|- | |||
| [[File:Endocrinology - An Integrated Approach.png|80px]] | |||
| Nussey, S and Saffron Whitehead, S. <i>Endocrinology: An Integrated Approach</i>. Oxford: BIOS Scientific Publishers; 2001. | |||
Chapter 6 [http://www.ncbi.nlm.nih.gov/books/NBK29 The gonad] | |||
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{{BGDB SexDiffn}} | |||
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Latest revision as of 11:46, 1 June 2019
Introduction
Practical 12: Sex Determination | Early Embryo | Late Embryo | Fetal | Postnatal | Abnormalities | 2011 Audio |
This practical will introduce the topic of sexual differentiation during development through a series of online resource pages.
Aim: This practical is an introduction to the earliest events in Sexual Differentiation.
Key Concepts: primordial germ cell, sex chromosomes, gonad, internal genitalia, external genitalia, ovary, testis, puberty, hormonal changes, gametogenesis, genital abnormalities (DSD).
Background
Genital Timeline
These are approximate timings and stages only.
- 24 days - intermediate mesoderm, pronephros primordium
- 28 days - mesonephros and mesonephric duct
- 35 days - uteric bud, metanephros, urogenital ridge
- 42 days - cloacal divison, gonadal primordium (indifferent)
- 49 days - paramesonephric duct, gonadal differentiation
- 56 days - paramesonephric duct fusion (female)
- 100 days - primary follicles (ovary)
- postnatal 2 months of age - male primordial germ cells (gonocytes) are replaced by adult dark (Ad) and pale (Ap) spermatogonia forming the spermatogonial stem cell (SSC) population.
Textbooks
Practical 12: Sex Determination | Early Embryo | Late Embryo | Fetal | Postnatal | Abnormalities | 2011 Audio |
BGDB: Lecture - Gastrointestinal System | Practical - Gastrointestinal System | Lecture - Face and Ear | Practical - Face and Ear | Lecture - Endocrine | Lecture - Sexual Differentiation | Practical - Sexual Differentiation | Tutorial
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2024, June 16) Embryology BGDB Practical - Sexual Differentiation. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/BGDB_Practical_-_Sexual_Differentiation
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G