1957 Adrenal Moore, K.L. & Persuad, T.V.N. (2008).
The Developing Human: clinically oriented embryology (8
th ed.). Philadelphia: Saunders. (chapter links only work with a UNSW connection). *
Nervous System *
Pharyngeal Apparatus, Face, and Neck Schoenwolf, G.C., Bleyl, S.B., Brauer, P.R. and Francis-West, P.H. (2009).
Larsen’s Human Embryology (4
th ed.). New York; Edinburgh: Churchill Livingstone. The following chapter links only work with a
UNSW Library subscription * Chapter 10 - Development of the Peripheral Nervous System * Chapter 16 - Development of the Pharyngeal Apparatus and Face Additional Resources * Developmental Biology. 6th edition.
The Neural Crest * Nelms BL, Labosky PA. Transcriptional Control of Neural Crest Development. San Rafael (CA): Morgan & Claypool Life Sciences; 2010. Available from:
http://www.ncbi.nlm.nih.gov/books/NBK53145/ * Dupin E, Creuzet S, Le Douarin NM. The Contribution of the Neural Crest to the Vertebrate Body. In: Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience; 2000-. Available from:
http://www.ncbi.nlm.nih.gov/books/NBK6098/ Objectives
Mouse neural crest (E10.5 ganglia Sox10)
* Understand the structures derived from ectoderm. * Understand the formation of neural folds. * Identify the initial location of neural crest cells in the trilaminar embryo. * Identify pathways of neural crest migration throughout the embryo. * To know the major tissues to which neural crest cells contribute. * To know how abnormalities in development that result from abnormal neural crest cell migration. * Understand how neural crest cells contribute to the pharyngeal arches and the head structures they form.
Neural Crest Derivatives
A key feature of neural crest is the migration into other embryonic tissues to form specific neural and non-neural populations and structures.
Cranial neural crest
*
migration - dorsolaterally and into pharyngeal arches * craniofacial mesenchyme - cartilage, bone, cranial neurons, glia, and connective tissues of the face * pharyngeal arches and pouches - thymic cells, tooth odontoblasts, middle ear bones (ossicles), stria vascularis cells, and jaw (mandible)
Cochlea - Stria Vascularis |
| |
Inner ear cochlea, showing the stria vascularis intermediate cells that are derived from neural crest. Hearing - Inner Ear Development |
Eye - Cornea |
| |
Human embryonic cornea detail (Week 8, Carnegie stage 22)
|
Mouse cornea layers
|
The adult eye cornea has three layers: an outer epithelium layer (ectoderm), a middle stromal layer of collagen-rich extracellular matrix between stromal keratocytes (neural crest) and an inner layer of endothelial cells (neural crest)
Vision - Cornea Development
|
Carotid body are chemoreceptors in the wall of the common carotid (3rd pharyngeal arch) [14][15]
Cardiac neural crest
- migration - located between the cranial and trunk neural crests, overlapping the anterior portion of the vagal neural crest.
- pharyngeal arches - (3,4,6) melanocytes, neurons, cartilage, and connective tissue
- heart outflow tract - aortic arch/pulmonary artery septum, large arteries wall musculoconnective tissue
Neural Crest - Cardiac
|
Cardiac Neural Crest Migration
|
Trunk neural crest
- migration - two major pathways over somites (dorsolaterally) and between somite and neural tube (ventrolaterally)
- dorsolateral - skin melanocytes
- ventrolaterally - dorsal root ganglia, sympathetic ganglia, adrenal medulla, aortic nerve clusters
para-aortic body
(organ of Zuckerkandl, OZ) A neural crest derived chromaffin body, anatomically located at the bifurcation of the aorta or at the origin of the inferior mesenteric artery. Thought to act as a fetal regulator of blood pressure, secreting catecholamines into the fetal circulation.[16] In human, reaches its maximal size at 3 years of age and then regresses either by death, dispersion or differentiation.[17]
Named in 1901 by Emil Zuckerkandl (1849-1910) a Hungarian-Austrian anatomist at the University of Vienna.
- Links: Cardiovascular System Development
Vagal and sacral neural crest
- migration - ventrally into surrounding splanchnic mesenchyme of gastrointestinal tract
- splanchnic mesenchyme - parasympathetic (enteric) ganglia of the gut
Development Overview
The following cranial and trunk data is based upon 185 serially sectioned staged (Carnegie) human embryos.[18]
Cranial Neural Crest
- stage 9 - an indication of mesencephalic neural crest
- stage 10 - trigeminal, facial, and postotic components
- stage 11 - crest-free zones are soon observable in rhombomere 1, 3, and 5
- stage 12 - rhombomeres 6 and 7 neural crest migrate to pharyngeal arch 3 and then rostrad to the truncus arteriosus
- stage 13 - nasal crest and the terminalis-vomeronasal complex are last of the cranial crest to appear
stages 9-14 - otic vesicle primordium descends
Vagal Neural Crest
Recent research suggests that the vagal neural crest cells are a transitional population that has evolved between the head and the trunk, taking separate pathways to the both the heart and to the gut.[19][20]
Trunk Neural Crest
Spinal ganglia increase in number over time and are in phase with the somites, though not their centre. There are 3 migratory pathways: ventrolateral between dermatomyotome and sclerotome, ventromedial between neural tube and sclerotomes, and lateral between surface ectoderm and dermatomyotome.
- stage 13 - about 19 present
- stage 14 - about 33 present
- stage 15-23 - 30–35 ganglia
Neck and Shoulder
A mouse study using individually labelled cells of postotic neural crest followed the development of the shoulder girdle (clavicle and scapula) that connects the upper limb to the axial skeleton.[21]
- Clavicle is a neural crest-mesodermal structure, posterior dermal clavicle mesoderm.
- Cryptic cell boundaries traverse apparently homogeneous skeleton of the neck and shoulders.
- Bones and muscles code of connectivity that mesenchymal stem cells of both neural crest and mesodermal origin obey
- Neural crest anchors the head onto the anterior lining of the shoulder girdle
- Hox-gene-controlled mesoderm links trunk muscles to the posterior neck and shoulder skeleton.
- Skeleton identified as neural crest-derived is affected in human Klippel-Feil syndrome, Sprengel's deformity and Arnold-Chiari I/II malformation.
Skin Melanocytes
|
|
Mouse melanocyte migration[22]
|
Movie Mouse Skin - Melanoblast Migration E14.5[23]
|
Neural Crest Migration
A key event in neural crest development is migration from the original site that neural crest cells are generated (edge of the neural plate) to the different anatomical regions within the embryo.
Stimulators
- complement component C3a - (C3a) acts as an autocrine diffusible chemotactic agent attracting NCC toward the self-secreted source.
Inhibitors
- versican - (VCAN, Chondroitin Sulfate Proteoglycan 2; Cspg2) an extracellular matrix proteoglycan that acts as both an inhibitor of NCC migration and as a guiding cue by forming exclusionary boundaries.[24]
- Links: OMIM 118661
Historic
The paper by Marshall, Morphology of the Vertebrate Olfactory Organ (1879)[2], was historically the first time the term "neural crest" was used. In his own earlier papers he had referred to this as a "neural ridge" in describing development of the chicken embryo neural tube.
See paper text and his referenced comment:
- "I take this opportunity to make a slight alteration in the nomenclature adopted in my former paper. I have there suggested the term neural ridge for the longitudinal ridge of cells which grows out from the reentering angle between the external epiblast and the neural canal, and from which the nerves, whether cranial or spinal, arise. Since this ridge appears before closure of the neural canal is effected, there are manifestly two neural ridges, one on either side ; but I have also applied the same term, neural ridge, to the single outgrowth formed by the fusion of the neural ridges of the two sides after complete closure of the neural canal is effected, and after the external epiblast has become completely separated from the neural canal. I propose in future to speak of this single median outgrowth as the neural crest, limiting the term neural ridge to the former acceptation. Thus, while there are two neural ridges, there is only one neural crest, a distinction that will be at once evident on reference to my former figures."
- Links: Embryology History
References
- ↑ 1.0 1.1 <pubmed>18689800</pubmed> Cite error: Invalid
<ref>
tag; name 'PMID18689800' defined multiple times with different content
- ↑ 2.0 2.1 Marshall AM. The morphology of the vertebrate olfactory organ. (1879) Quarterly Journal of Microscopic Science. 19: 300–340.
- ↑ 3.0 3.1 Cox SG, Kim H, Garnett AT, Medeiros DM, An W & Crump JG. (2012). An essential role of variant histone H3.3 for ectomesenchyme potential of the cranial neural crest. PLoS Genet. , 8, e1002938. PMID: 23028350 DOI.
- ↑ Uribe RA, Hong SS & Bronner ME. (2018). Retinoic acid temporally orchestrates colonization of the gut by vagal neural crest cells. Dev. Biol. , 433, 17-32. PMID: 29108781 DOI.
- ↑ Mimura S, Suga M, Okada K, Kinehara M, Nikawa H & Furue MK. (2016). Bone morphogenetic protein 4 promotes craniofacial neural crest induction from human pluripotent stem cells. Int. J. Dev. Biol. , 60, 21-8. PMID: 26934293 DOI.
- ↑ Causeret F, Ensini M, Teissier A, Kessaris N, Richardson WD, Lucas de Couville T & Pierani A. (2011). Dbx1-expressing cells are necessary for the survival of the mammalian anterior neural and craniofacial structures. PLoS ONE , 6, e19367. PMID: 21552538 DOI.
- ↑ Betters E, Liu Y, Kjaeldgaard A, Sundström E & García-Castro MI. (2010). Analysis of early human neural crest development. Dev. Biol. , 344, 578-92. PMID: 20478300 DOI.
- ↑ Kulesa PM, Bailey CM, Kasemeier-Kulesa JC & McLennan R. (2010). Cranial neural crest migration: new rules for an old road. Dev. Biol. , 344, 543-54. PMID: 20399765 DOI.
- ↑ Lee G, Chambers SM, Tomishima MJ & Studer L. (2010). Derivation of neural crest cells from human pluripotent stem cells. Nat Protoc , 5, 688-701. PMID: 20360764 DOI.
- ↑ Green SA, Simoes-Costa M & Bronner ME. (2015). Evolution of vertebrates as viewed from the crest. Nature , 520, 474-482. PMID: 25903629 DOI.
- ↑ Woodhoo A & Sommer L. (2008). Development of the Schwann cell lineage: from the neural crest to the myelinated nerve. Glia , 56, 1481-90. PMID: 18803317 DOI.
- ↑ Barraud P, Seferiadis AA, Tyson LD, Zwart MF, Szabo-Rogers HL, Ruhrberg C, Liu KJ & Baker CV. (2010). Neural crest origin of olfactory ensheathing glia. Proc. Natl. Acad. Sci. U.S.A. , 107, 21040-5. PMID: 21078992 DOI.
- ↑ <pubmed>10683170</pubmed>
- ↑ Smith P, Scraggs M & Heath D. (1993). The development of the nerve network in the fetal human carotid body and its subsequent function in cardiac disease. Cardioscience , 4, 143-9. PMID: 8400021
- ↑ Hempleman SC & Warburton SJ. (2013). Comparative embryology of the carotid body. Respir Physiol Neurobiol , 185, 3-8. PMID: 22902512 DOI.
- ↑ WEST GB, SHEPHERD DM, HUNTER RB & MACGREGOR AR. (1953). The function of the organs of Zuckerkandl. Clin Sci , 12, 317-25. PMID: 13107111
- ↑ <pubmed>23078542</pubmed>
- ↑ O'Rahilly R & Müller F. (2007). The development of the neural crest in the human. J. Anat. , 211, 335-51. PMID: 17848161 DOI.
- ↑ <pubmed>20962585</pubmed>
- ↑ Bryan R. Kuo, Carol A. Erickson Vagal neural crest cell migratory behavior: A transition between the cranial and trunk crest. Volume 240, Issue 9, pages 2084–2100, September 2011 Dev Dynamics
- ↑ Matsuoka T, Ahlberg PE, Kessaris N, Iannarelli P, Dennehy U, Richardson WD, McMahon AP & Koentges G. (2005). Neural crest origins of the neck and shoulder. Nature , 436, 347-55. PMID: 16034409 DOI.
- ↑ Matsuoka T, Ahlberg PE, Kessaris N, Iannarelli P, Dennehy U, Richardson WD, McMahon AP & Koentges G. (2005). Neural crest origins of the neck and shoulder. Nature , 436, 347-55. PMID: 16034409 DOI.
- ↑ Mort RL, Hay L & Jackson IJ. (2010). Ex vivo live imaging of melanoblast migration in embryonic mouse skin. Pigment Cell Melanoma Res , 23, 299-301. PMID: 20067551 DOI.
- ↑ Szabó A, Melchionda M, Nastasi G, Woods ML, Campo S, Perris R & Mayor R. (2016). In vivo confinement promotes collective migration of neural crest cells. J. Cell Biol. , 213, 543-55. PMID: 27241911 DOI.
Books
Trainor, P. (ed) Neural crest cells: evolution, development and disease. ISBN: 978-0-12-401730-6 ScienceDirect
Nelms BL, Labosky PA. Transcriptional Control of Neural Crest Development. San Rafael (CA): Morgan & Claypool Life Sciences; 2010. PMID 21452438
Reviews
Bronner ME & Simões-Costa M. (2016). The Neural Crest Migrating into the Twenty-First Century. Curr. Top. Dev. Biol. , 116, 115-34. PMID: 26970616 DOI.
Green SA, Simoes-Costa M & Bronner ME. (2015). Evolution of vertebrates as viewed from the crest. Nature , 520, 474-482. PMID: 25903629 DOI.
Lee YH & Saint-Jeannet JP. (2011). Sox9 function in craniofacial development and disease. Genesis , 49, 200-8. PMID: 21309066 DOI.
Kish PE, Bohnsack BL, Gallina D, Kasprick DS & Kahana A. (2011). The eye as an organizer of craniofacial development. Genesis , 49, 222-30. PMID: 21309065 DOI.
Jiang M, Stanke J & Lahti JM. (2011). The connections between neural crest development and neuroblastoma. Curr. Top. Dev. Biol. , 94, 77-127. PMID: 21295685 DOI.
PubmedParser error: The PubmedParser extension received invalid XML data. ()
Articles
O'Rahilly R & Müller F. (2007). The development of the neural crest in the human. J. Anat. , 211, 335-51. PMID: 17848161 DOI.
Search PubMed
Search Pubmed: Neural Crest Development
NCBI - Policies and Guidelines | PubMed | Help:Reference Tutorial
Additional Images
Mouse E9.5 neural crest - Crabp1, Sox10, Pax3 PMID 24409333
Model neural crest mesenchymal condensation
Cardiac Neural Crest Migration
Hindbrain neural crest migration
Mouse head E9 neural crest GFP
Historic Images
Historic Disclaimer - information about historic embryology pages
|
Pages where the terms "Historic" (textbooks, papers, people, recommendations) appear on this site, and sections within pages where this disclaimer appears, indicate that the content and scientific understanding are specific to the time of publication. This means that while some scientific descriptions are still accurate, the terminology and interpretation of the developmental mechanisms reflect the understanding at the time of original publication and those of the preceding periods, these terms, interpretations and recommendations may not reflect our current scientific understanding. (More? Embryology History | Historic Embryology Papers)
|
Great plexuses of the sympathetic system
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2024, June 16) Embryology Neural Crest Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Neural_Crest_Development
- What Links Here?
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G