Peer Review (Lab 10)
Group 1 (Adrenal Medulla)
The content under the history section is very well elaborated and thorough. It would be good to further develop the content in the rest of the sections similarly to what is being done in the history section. Under the subheading "Developmental time course", it will be nice to include a timeline for readers to better visualise the events occurring over the period of the development of the adrenal gland; a diagram works fine as well!
There appears to be a lack of references under the section "Tissue/organ structure", but the content inside is well developed and progresses smoothly. Under "Molecular mechanisms/factors/genes", it would be great to clearly identify the type of transcription/growth factors that influences the differentiation of cell types in the adrenal medulla mentioned under "Tissue/organ structure". The transcription/growth factors can be divided into smaller subsections for each of the factor as well before further elaboration is made.
Likewise, under the section "Animal models", subsections of the different animal models studied can be listed out, highlighting a few of the prominent key findings that are discovered on ox, sheep, swine and mice that was mentioned in the first paragraph of the section. It would be good to expand on all the findings and references listed in the last paragraph of the section and categorise them into the respective subsections.
Overall, apart of the missing content in some of the subheadings, the overall flow of the information is smooth and easy to digest. With some tidying up of the reference links and further elaboration in the content, the page would be good to go! Keep pushing and include more images wherever possible because it really helps to grasp the interest of the readers and also make the content easier to comprehend.
Group 3 (Melanocytes)
The organisation of the project is concise yet informative for someone who wishes to know more about melanocytes and their embryonic development. The illustrations are strategically placed to allow easier understanding of the content elaborated. The transition between each paragraph is smooth and is able to sustain the interest of the readers well. There are not much issues with regards to the referencing of your sources but it would be good to align the images to either side of the page so that it is easier for readers to relate the content to the illustrations.
The content in the "Introduction", "History" and "Tissue Organ Structure and Function" sections are well developed and display great understanding of the topic. I love how the content is further divided into smaller subheadings under the "Tissue Organ Structure and Function" section as it helps readers to compare and contrast the origins and function of the melanosomes in each organ described. Perhaps more content can be supplemented under the "Heart" subsection, such as its function and purpose.
Content listed in the "Embryonic Origins" section seems to be substantial but it would be good to include either a diagram or a timeline (or if possible, both) to illustrate the developmental process right from the pluripotent cells in the neural crest into the subsequent melanocytes found in the ears, eyes, skin and leptomeninges. It would be good to include any pathway involved in the developmental process as well. The content under the subsection "Cochlear melanocytes of the inner ear" appears to be incomplete and it would be good to elaborate on the eyes and skin as well since it was previously mentioned earlier in the page.
The "development time course" section can be merged together with the "Embryonic Origin" to make the content more coherent. More content can be added into the "Molecular Mechanisms/ Factors/ Genes" section, probably a summary of the signalling pathway for differentiation of melanocytes as well as the main transcription/growth factors involved. Other animal models studied can also be included if relevant, as it will complement the content listed under the "Animal Models" section. The image (Figure 4) appears to be disconnected with the information about animal models and it would be good to further elaborate on the relevance of the image to the content stated under this subheading.
There seems to be some incomplete content under the "Abnormalities" section which requires some touching up and expansion. Apart from that, the overall progress of the page seems promising! Keep up the good work!
Group 4 (Cardiac)
The amount of information in the project page is amazing and well developed. The structure of the page is well defined, though there is some transitional complications between some sections. It would also be good to supplement the content with more illustrations to sustain the attention of the readers and for them to better digest the content written.
The introduction is concise and brief, describing the overview of the cardiovascular system and touching on the studies done on animal models as well as cardiac developmental abnormalities. However, I feel that the entire section of "Neural Crest and Cardiac Development" can be merged together under a common subheading of "Embryonic Developmental origins" with the later parts of "Early Development" and "Later Development" as it feels like they are essentially talking about the same topic. Instead, the introduction can include the content under the "Cardiac Neural Crest Cells" section and further supplemented with a brief history about the discovery of cardiac neural crest cells, if any. From there, the transition to the later parts of the page would be much more pleasant for readers to understand the topic better.
Subsequent parts on "Early Development" and "Later Development" are well furnished with detailed information outlying the pathways and signalling factors involved in development. This can be further supplemented with illustrations on the key points under each subheadings if possible, or a simple hand drawn diagram would suffice too. This would be beneficial for readers to visualise the process of development into cardiac neural crest cells.
The key signalling molecules are listed clearly with description of each of their involvement in cardiac neural crest cells. I love how the table in the "Development Time Course" section gives an overview of the development process of the cardiac system.
There appears to be incomplete editing under "Models and Research", as well as the "Human Congenital Heart Diseases associated with Neural Crest Cells". However, the content seems to be available, just that some polishing of the information and reference editing are necessary. More details should be furnished under the "Research" section as it seems to be inadequate information in that area.
Some referencing errors, in terms of formatting and missing PMID, are detected under the "References" section, but should be easily corrected once the final polishing and edits are made before the project is finalised. As long as the missing information are supplemented accordingly, the final content in the project should be able to effectively provide insights in the development of the cardiac system.
Adding an Image
Neuropore cell shape changes
In vitro maturation recent article