Ultrasound - Nuchal Translucency

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Introduction

Ultrasound nuchal translucency
File:Ultrasound nuchal translucency[1]
Ultrasound Imaging planes
Ultrasound Imaging planes

Nuchal translucency (NT) is the normal fluid-filled subcutaneous space that can be measured by ultrasound imaging between GA week 11 to 14 and is used as a diagnostic "soft marker", a measured increase in this space can relate to Trisomy 21 and other neural and chromosomal conditions in the fetus.

The term "soft markers" refers to ultrasound measurements which may not be diagnostic by themselves, but can have an indicative role for further diagnostic analysis of the pregnancy.

The Diagnostic Imaging Committee of the Society of Obstetricians and Gynaecologists of Canada in 2005[2] made the following recommendations:

  1. The screening ultrasound at 16 to 20 weeks should evaluate 8 markers, 5 of which (thickened nuchal fold, echogenic bowel, mild ventriculomegaly, echogenic focus in the heart, and choroid plexus cyst) are associated with an increased risk of fetal aneuploidy, and in some cases with nonchromosomal problems, while 3 (single umbilical artery, enlarged cisterna magna, and pyelectasis) are only associated with an increased risk of nonchromosomal abnormalities when seen in isolation (II-2 B).
  2. Identification of soft markers for fetal aneuploidy requires correlation with other risk factors, including history, maternal age, and maternal serum testing results (II-1 A).
  3. Soft markers identify a significant increase in fetal risk for genetic disease. Timely referral for confirmation, counselling, and investigation is required to maximize management options (III-B).


Ultrasound can also be used in combination with other techniques to locate both embryo and placenta for other prenatal tests (More? prenatal diagnosis).

The ultrasound technique can be used at any stage during pregnancy for fetal and placenta monitoring (More? Placenta Development | Placenta Abnormalities | Prenatal Diagnosis).


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Movie shows a 12 week fetus in 3d in realtime (hence 4D).
Special thanks to Dr Andrew McLennan, Foetal Medicine Unit, Royal North Shore Hospital for many of the original video materials.


Diagnosis Links: Prenatal Diagnosis | pregnancy test | amniocentesis | chorionic villus sampling | ultrasound | Alpha-Fetoprotein | Pregnancy-associated plasma protein-A | Fetal Blood Sampling | Magnetic Resonance Imaging | Computed Tomography | Non-Invasive Prenatal Testing | Fetal Cells in Maternal Blood | Preimplantation Genetic Screening | Comparative Genomic Hybridization | Genome Sequencing | Neonatal Diagnosis | Category:Prenatal Diagnosis | Fetal Surgery | Classification of Diseases | Category:Neonatal Diagnosis

| Abnormal Ultrasound

Some Recent Findings

  • Cut-off value for normal nuchal translucency evaluated by chromosomal microarray analysis[3] "An association between isolated, increased nuchal translucency thickness and pathogenic chromosomal microarray analysis (CMA) has been reported. A recent meta-analysis reported that most studies used a 3.5 mm cut-off value. Considering nuchal translucency distribution and the commonly accepted 5% false positive rate in maternal serum screening, nuchal translucency cut-off levels should be reconsidered. This study evaluated the unique contribution of CMA to the investigation of foetuses with mildly increased nuchal translucency (NT) thickness of 3.0-3.4 mm."
More recent papers  
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Search term: Nuchal Translucency

<pubmed limit=5>Nuchal Translucency</pubmed>

Neural

Neural
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 ‎‎Dandy-Walker
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 ‎‎Spina Bifida
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Anencephaly ultrasound.jpg

Anencephaly ultrasound[4]

Ultrasound Gestational Age

The following table is based upon Australian data from ultrasound measurements of Crown Rump Length (CRL).[5]

Note that Gestational Age GA differs from fertilisation age by about 2 weeks.

Gestational Age and Crown-Rump Length (measured by ultrasound
Gestational Age
GA (week.day)
Crown-Rump
Length (CRL)
5.2 1
5.3 2
5.4 3
55 3
5.6 4
6 4
6.1 5
6.2 6
6.3 7
6.4 8
6.5 9
6.6 10
7 11
7.1 11
7.2 12
7.3 12
7.4 13
7.5 14
7.6 15
8 17
8.1 18
8.2 19
8.3 20
8.4 21
8.5 22
8.6 22
9 23
9.1 24
9.2 26
9.3 27
9.4 28
9.5 29
9.6 31
10 34
10.1 36
10.2 37
10.3 38
10.4 39
10.5 39
10.6 40
11 44
11.1 45
11.2 47
11.3 48
11.4 52
11.5 55
11.6 56
12 57
12.1 58
12.2 60
12.3 61
12.4 63
12.5 64
12.6 65
13 68
13.1 70
13.2 72
13.3 74
113.4 76
135 77
13.6 80
14 81
14.1 84
14.2 85
14.3 86
14.4 87
Reference

Table adapted from Westerway (2015) PDF and <pubmed>11065037</pubmed>

Fertilization and Gestational Age - Crown-Rump Length (ultrasound
Fertilization Age
(days)
Gestational Age
GA (week.day)
Crown-Rump
Length (mm)
37 5.2 1
38 5.3 2
39 5.4 3
40 55 3
41 5.6 4
42    Week 4 6 4
43 6.1 5
44 6.2 6
45 6.3 7
46 6.4 8
47 6.5 9
48 6.6 10
49    Week 5 7 11
50 7.1 11
51 7.2 12
52 7.3 12
53 7.4 13
54 7.5 14
55 7.6 15
56    Week 6 8 17
57 8.1 18
58 8.2 19
59 8.3 20
60 8.4 21
61 8.5 22
62 8.6 22
63    Week 7 9 23
64 9.1 24
65 9.2 26
66 9.3 27
67 9.4 28
68 9.5 29
69 9.6 31
70    Week 8 10 34
71 10.1 36
72 10.2 37
73 10.3 38
74 10.4 39
75 10.5 39
76 10.6 40
77    Week 9 11 44
78 11.1 45
79 11.2 47
80 11.3 48
81 11.4 52
82 11.5 55
83 11.6 56
84    Week 10 12 57
85 12.1 58
86 12.2 60
87 12.3 61
88 12.4 63
89 12.5 64
90 12.6 65
91    Week 11 13 68
92 13.1 70
93 13.2 72
94 13.3 74
95 113.4 76
96 135 77
97 13.6 80
98    Week 12 14 81
99 14.1 84
100 14.2 85
101 14.3 86
102 14.4 87
Reference: Table data measured by ultrasound, adapted from Westerway (2015) PDF and[5]
Links: ultrasound | Fetal Development

CRL-GA TableFA-GA-CRL


Additional Images

References

  1. <pubmed>24288543</pubmed>| Obstet Gynecol Int.
  2. <pubmed>16100637</pubmed>
  3. <pubmed>28133835</pubmed>
  4. <pubmed>21042439</pubmed>
  5. 5.0 5.1 <pubmed>11065037</pubmed> Cite error: Invalid <ref> tag; name "PMID11065037" defined multiple times with different content


Journals

Books

Molecular Imaging and Contrast Agent Database (MICAD) NBK5330 | PMID:20641179

Articles

<pubmed>24518917</pubmed> <pubmed>22660228</pubmed>

Search PubMed

Search PubMed: Ultrasound prenatal diagnosis | Ultrasound


Prenatal Diagnosis Terms

  • blastomere biopsy - An ART preimplantation genetic diagnosis technique carried out at cleavage stage (day 3), excluding poor quality embryos, detects chromosomal abnormalities of both maternal and paternal origin. May not detect cellular mosaicism in the embryo.
  • blastocyst biopsy - An ART preimplantation genetic diagnosis technique carried out at blastocyst stage (day 4-5), removes several trophoblast (trophoderm) cells, detects chromosomal abnormalities of both maternal and paternal origin and may detect cellular mosaicism.
  • cell-free fetal deoxyribonucleic acid - (cffDNA) refers to fetal DNA circulating and isolated from the plasma portion of maternal blood.
  • false negative rate - The proportion of pregnancies that will test negative given that the congenital anomaly is present.
  • false positive rate - The proportion of pregnancies that will test positive given that the congenital anomaly is absent.
  • free β human chorionic gonadotrophin - beta-hCG subunit of hCG used as a diagnostic marker for: early detection of pregnancy, Trisomy 21, spontaneous abortion, ectopic pregnancy, hydatidiform mole or choriocarcinoma.
  • multiples of the median - (MoM) A multiple of the median is a measure of how far an individual test result deviates from the median and is used to report the results of medical screening tests, particularly where the results of the individual tests are highly variable.
  • negative predictive value - The probability that a congenital anomaly is absent given that the prenatal screening test is negative.
  • Non-Invasive Prenatal Testing - (NIPT) could refer to ultrasound or other imaging techniques, but more frequently used to describe analysis of cell-free fetal DNA circulating in maternal blood.
  • polar body biopsy - (PB biopsy) An ART preimplantation genetic diagnosis technique that removes either the first or second polar body from the zygote. As these are generated by oocyte meiosis they detects chromosomal abnormalities only on the female genetics.
  • positive predictive value - The probability that a congenital anomaly is present given that the prenatal screening test is positive.
  • pre-implantation genetic diagnosis - (PGD, pre-implantation genetic screening) a diagnostic procedure for embryos produced through Assisted Reproductive Technology (ART, in vitro fertilisation, IVF) for genetic diseases that would generate developmental abnormalities or serious postnatal diseases.
  • prenatal screening sensitivity - (detection rate) The probability of testing positive on a prenatal screening test if the congenital anomaly is present.
  • prenatal screening specificity - The probability of testing negative on a prenatal screening test if the congenital anomaly is absent.
  • single nucleotide polymorphisms - (SNPs) the variation in a single DNA nucleotide that occurs at a specific position in the genome.
Other Terms Lists  
Terms Lists: ART | Birth | Bone | Cardiovascular | Cell Division | Endocrine | Gastrointestinal | Genital | Genetic | Head | Hearing | Heart | Immune | Integumentary | Neonatal | Neural | Oocyte | Palate | Placenta | Radiation | Renal | Respiratory | Spermatozoa | Statistics | Tooth | Ultrasound | Vision | Historic | Drugs | Glossary

Terms

Ultrasound

  • Biparietal diameter - (BPD) used to determine fetal age and normal development (small/large/abnormal) parameters. Measured as the diameter between the 2 sides of the head, measurements after 13 weeks (2.4 cm) to term (9.5 cm).
  • cerebroplacental ratio - (CPR) a doppler ultrasound measurement calculated as the simple ratio between the middle cerebral artery pulsatility index (MCA‐PI) and the {{placenta]]l artery pulsatility index (UA‐PI). Fetuses with an abnormal ratio are thought to be a predictor of adverse pregnancy outcome such as: small for gestational age, abnormal fetal heart rate pattern, meconium stained liquor, low Apgar score, and acidosis at birth. PMID 28216258
  • Crown-Rump Length - (CRL) measurement used in embryology to more accurately stage the early embryo and fetus. Measured from the curvature at the top (crown) to the curvature at the bottom (rump) of the "C-shaped" early embryo. Used in clinical ultrasound as a measurement between the periods of 7 to 13 weeks as an accurate estimation of the gestational age GA.
  • DICOM - (ISO standard 12052:2006) Acronym for Digital Imaging and Communications in Medicine, a clinical standard for handling, storing, printing, and transmitting imaging information.
  • Femur length - (FL) is used to determine fetal age and normal development (small/large/abnormal) parameters. The femur is the longest bone in the body and measurements and reflects the longitudinal growth of the fetus (approximately 14 weeks 1.5 cm - term 7.8 cm). It is one of the four typical ultrasound assessments of fetal size and age: Biparietal Diameter (BPD), |Head Circumference (HC), Abdominal Circumference (AC), and Femur Length (FL).
  • Fetal size and age - typically measured using 4 ultrasound assessments: Biparietal Diameter (BPD), Head Circumference (HC), Abdominal Circumference (AC), and Femur Length (FL).
  • Functional linear discriminant analysis - (FLDA) new growth assessment technique using serial measurements to discriminate between normal and abnormal fetal growth during 2nd and 3rd trimester.
  • Head Circumference - (HC) Measured as an ellipse in a horizontal section at the level of the thalamus and the cavum septi pellucidi. 2nd trimester Fetal head growth
  • Gestational sac - (GS) size formed initially by the chorionic cavity, after the embryonic period (week 8, GA W10) the amniotic cavity expands and fuses with the chorion. Measured by mean gestation sac diameter.
  • inversion mode - an ultrasound processing method of volume analysis for the visualization of fluid-filled fetal structures such as; heart chambers, vessel lumen, stomach, gallbladder, renal pelvis, and the bladder. Post-processing inverts the gray scale of the volume voxels showing the normally anechoic structures in 3D or 4D renderings. This technique has been used to identify cardiac anomalies.
  • Linear discriminant analysis - (LDA) to longitudinal data (James and Hastie, 2001)
  • Mean gestation sac diameter - (MSD) = (length + height + width)/3. At week 3 (GAweek 5) MSD measures 2-3 mm. Normal MSD (in mm) + 30 = days of pregnancy.
  • Mean yolk sac diameter - (MYD) can be used as marker for subsequent embryonic death or abnormalities (PMID 22215774).
  • Spatiotemporal image correlation (STIC) - an image acquisition method used mainly for fetal heart analysis. Requires two steps; an automatic volume sweep, then image data analysis according to spatial and temporal domain generating an online dynamic 3D image sequence.
  • Transvaginal scan - (TVS) the ultrasound probe is placed inside the vagina and scans for female genital (uterus, ovary) and ectopic pregnancy.
  • Termination of pregnancy - (TOP)
Other Terms Lists  
Terms Lists: ART | Birth | Bone | Cardiovascular | Cell Division | Endocrine | Gastrointestinal | Genital | Genetic | Head | Hearing | Heart | Immune | Integumentary | Neonatal | Neural | Oocyte | Palate | Placenta | Radiation | Renal | Respiratory | Spermatozoa | Statistics | Tooth | Ultrasound | Vision | Historic | Drugs | Glossary


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Cite this page: Hill, M.A. (2019, August 21) Embryology Ultrasound - Nuchal Translucency. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Ultrasound_-_Nuchal_Translucency

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© Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G