Postnatal - Vaccination

From Embryology
Embryology - 30 Mar 2017    Facebook link Pinterest link Twitter link  Expand to Translate  
Google Translate - select your language from the list shown below (this will open a new external page)

العربية | català | 中文 | 中國傳統的 | français | Deutsche | עִברִית | हिंदी | bahasa Indonesia | italiano | 日本語 | 한국어 | မြန်မာ | Pilipino | Polskie | português | ਪੰਜਾਬੀ ਦੇ | Română | русский | Español | Swahili | Svensk | ไทย | Türkçe | اردو | ייִדיש | Tiếng Việt    These external translations are automated and may not be accurate. (More? About Translations)

Educational Use Only - Embryology is an educational resource for learning concepts in embryological development, no clinical information is provided and content should not be used for any other purpose.


Community immunity
Community immunity
Australian Public Health Activities (2007-08)

Although the use of most vaccines during pregnancy is not usually recommended on precautionary grounds, there is no convincing evidence that pregnancy should be an absolute contraindication to the use of any vaccine, particularly inactivated vaccines. The only exception is vaccinia virus (smallpox vaccination), which has been shown to cause fetal malformation. For Australian information see the Australian Immunisation Handbook (June2015)[1]

AIH 10th edition 3.3.2 - Women planning pregnancy "The need for vaccination, particularly for hepatitis B, measles, mumps, rubella and varicella, should be assessed as part of any pre-conception health check. Where previous vaccination history or infection is uncertain, relevant serological testing can be undertaken to ascertain immunity to hepatitis B, measles, mumps and rubella."

Tinycc Vaccination page -

Links: Viral Infection | Infectious Diseases School Exclusion

Viral Links: TORCH Infections | Cytomegalovirus | Hepatitis Virus | HIV | Parvovirus | Polio Virus | Rubella Virus | Chickenpox | Lymphocytic Choriomeningitis Virus | Zika Virus | Vaccination | Environmental
Neonatal Diagnosis: APGAR test | Guthrie test | Hearing test | Electrocardiogram (ECG/EKG) | X-ray | Tandem mass spectrometry | Classification of Diseases

Some Recent Findings

  • Trivalent inactivated influenza vaccine and spontaneous abortion[2] "Our final analysis included 243 women with spontaneous abortion and 243 matched control group women; 82% of women with spontaneous abortion had ultrasound confirmation of fetal demise. ...There was no statistically significant increase in the risk of pregnancy loss in the 4 weeks after seasonal inactivated influenza vaccination."
  • Influenza A/H1N1 MF59 adjuvanted vaccine in pregnant women and adverse perinatal outcomes: multicentre study[3] "This large study using primary data collection found that MF59 adjuvanted A/H1N1 influenza vaccine did not result in an increased risk of adverse perinatal events and suggested a lower risk among vaccinated women. These findings should contribute to inform stakeholders and decision makers on the prescription of vaccination against influenza A/H1N1 in pregnant women."
More recent papers  
Mark Hill.jpg
PubMed logo.gif

This table shows an automated computer PubMed search using the listed sub-heading term.

  • Therefore the list of references do not reflect any editorial selection of material based on content or relevance.
  • References appear in this list based upon the date of the actual page viewing.

References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.

Links: References | Discussion Page | Pubmed Most Recent | Journal Searches

Search term: Vaccination Postnatal Vaccination

YunLong Xu, Fen He, FangFang Qi, Guangqi Yang, FuXiang Zheng, JunHua Yang, Xiao Wang, JunXiu Liu, JunTao Zou Remodeling the Th1 polarized systemic environment contributes to neurogenesis and cognitive function via the Wnt7a pathway in neonatal mice. Neurobiol Learn Mem: 2017; PubMed 28342972

Katharine J McCarthy, Sandra Braganza, Kevin Fiori, Christophe Gbeleou, Vivien Kpakpo, Andrew Lopez, Jennifer Schechter, Alicia Singham Goodwin, Heidi E Jones Identifying inequities in maternal and child health through risk stratification to inform health systems strengthening in Northern Togo. PLoS ONE: 2017, 12(3);e0173445 PubMed 28301539

Muhammad Tahir Khan, Sidra Zaheer, Kashif Shafique Maternal education, empowerment, economic status and child polio vaccination uptake in Pakistan: a population based cross sectional study. BMJ Open: 2017, 7(3);e013853 PubMed 28283489

Liisa Lehtonen, Ana Gimeno, Anna Parra-Llorca, Máximo Vento Early neonatal death: A challenge worldwide. Semin Fetal Neonatal Med: 2017; PubMed 28238633

María Clara Restrepo-Méndez, Aluísio J D Barros, Kerry L M Wong, Hope L Johnson, George Pariyo, Fernando C Wehrmeister, Cesar G Victora Missed opportunities in full immunization coverage: findings from low- and lower-middle-income countries. Glob Health Action: 2016, 9(1);30963 PubMed 28156945

Neonatal Vaccination

Vaccination of premature infants

A recent study has looked at Wheezing lower respiratory disease hazard ratios (HR) for vaccination of premature infants.[4] Premature infants are at increased risk of wheezing in association with respiratory syncytial virus (RSV) and rhinovirus infections. The study found no evidence of increased WLRD risk following routine vaccinations of premature infants. WLRD risk among non-fragile premature infants appears to be reduced for a few weeks after live attenuated vaccinations.

"Wheezing lower respiratory disease hazard ratios (HR) were not significantly elevated for any vaccine type among non-fragile or fragile premature infants. Among non-fragile infants the 8-14 days HR was significantly reduced for live attenuated MMR (0.68, 0.52-0.88) and Varicella (0.71, 0.53-0.94) vaccines, and similarly but insignificantly reduced for infrequently used live attenuated OPV vaccine (0.70, 0.46-1.06). There was a smaller significant reduction (0.83, 0.69-0.998) in the 15-30 days HR for MMR and a similar but not significant reduction (0.86, 0.71-1.05) in the 31-44 days HR for MMR. Hepatitis B vaccine (HBV), which is not a live vaccine, had significantly reduced 8-14 days (0.84, 0.72-0.98) and 31-44 days (0.88, 0.78-0.98) HRs among non-fragile infants. The apparent protective effect of HBV may be confounded by live vaccines administered simultaneously with the third dose of HBV. Among fragile infants there was a large significant reduction in the 8-14 days HR for live attenuated OPV vaccine (0.40, 0.23-0.70) and smaller significant reductions in the 8-14 days HR for inactivated DTaP (0.82, 0.71-0.95), Hib (0.83, 0.73-0.96), and PCV7 (0.84, 0.70-0.997) vaccines. Delays in vaccinating fragile infants may have made simultaneous administration of live vaccines and third doses of these inactivated vaccines more likely."

Australian Immunisation Handbook

The purpose of The Australian Immunisation Handbook is to provide clinical guidelines for health professionals on the safest and most effective use of vaccines in their practice. These recommendations are developed by the Australian Technical Advisory Group on Immunisation (ATAGI) and endorsed by the National Health and Medical Research Council (NHMRC).

There is a specific section within the handbook for Vaccination of women planning pregnancy, pregnant or breastfeeding women, and preterm infants.

Links: AIH 10th edition (June 2015) | V3.3.2 Vaccination of women who are planning pregnancy, pregnant or breastfeeding, and preterm infants (June 2015) | AIH 9th edition (2008)

Australian Child Immunisation Programs 2013  
Age Vaccine
  • Hepatitis B (hepB)a
2 months
  • Hepatitis B, diphtheria, tetanus, acellular pertussis (whooping cough), Haemophilus influenzae type b, inactivated poliomyelitis (polio) (hepB-DTPa-Hib-IPV)
  • Pneumococcal conjugate (13vPCV)
  • Rotavirus
4 months
  • Hepatitis B, diphtheria, tetanus, acellular pertussis (whooping cough), Haemophilus influenzae type b, inactivated poliomyelitis (polio) (hepB-DTPa-Hib-IPV)
  • Pneumococcal conjugate (13vPCV)
  • Rotavirus
6 months
  • Hepatitis B, diphtheria, tetanus, acellular pertussis (whooping cough), Haemophilus influenzae type b, inactivated poliomyelitis (polio) (hepB-DTPa-Hib-IPV)
  • Pneumococcal conjugate (13vPCV)
  • Rotavirusb
12 months
  • Haemophilus influenzae type b (Hib)
  • Meningococcal C (MenCCV)

  • Measles, mumps and rubella (MMR)
18 months
  • Varicella (chickenpox)
4 years
  • Diphtheria, tetanus, acellular pertussis (whooping cough) and inactivated poliomyelitis (polio) (DTPa-IPV)
  • Measles, mumps and rubella (MMR)
  Notes: Information provided for educational purposes only. Postnatal - Vaccination | Immunise Australia Program

a Hepatitis B vaccine: should be given to all infants as soon as practicable after birth. The greatest benefit is if given within 24 hours, and must be given within 7 days.

b Rotavirus vaccine: third dose of vaccine is dependent on vaccine brand used.

  Source: Australian Immunisation Handbook 10th edition (April 2013).[1] National Immunisation Program Schedule From 1 February 2013 to 30 June 2013 PDF Immunise Australia Program.


There have been significant changes to the vaccines offered in the NSW vaccination program over time:

  • 1988, NSW conducted a Bicentennial measles campaign which offered measles vaccine to all child care and primary school age children.
  • 1998 the national Measles Control Campaign, which was the first national mass vaccination program since the 1950s polio campaigns, offered measles, mumps, rubella vaccine to all primary school children laying the groundwork that has resulted in the World Health Organization declaration of measles elimination in Australia
  • 2003 the meningococcal C vaccine was offered to all 1 – 19 year olds over a two year period
  • 2004 a hepatitis B vaccine catch up program was conducted for Year 7 students who had not received a primary course of vaccine and continued until 2013.
  • 2007 the three-dose course of human papillomavirus (HPV) vaccine was offered to female students in Years 10-12 . In 2008 it was offered to female students in Years 7 – 10, and routinely to female students in Year 7 from 2009 and was introduced routinely for male students in Year 7 in 2013 with a catch-up program for male students in Year 9 in 2013 and 2014 only
  • booster dose of diphtheria-tetanus-pertussis (dTpa) vaccine was offered to students in Years 7-12 in 2004, in Year 7 in 2005, in Year 10 from 2009-2012 and has been routinely offered to students in Year 7 from 2010 onwards
  • catch-up dose of varicella (chicken pox) vaccine has been offered to students in Year 7 since 2006

(From NSW Health - Communicable Diseases)

USA Recommended Immunizations for Children

(Birth through 6 years)

USA recommended immunizations for children 2013.jpg

Links: Vaccines | Advisory Committee on Immunization Practices (ACIP) Recommended Immunization Schedule for Persons Aged 0 Through 18 Years — United States, 2013


  1. 1.0 1.1 Australian Immunisation Handbook [ AIH 10th edition (June 2015) Cite error: Invalid <ref> tag; name "AIH10" defined multiple times with different content
  2. Stephanie A Irving, Burney A Kieke, James G Donahue, Maria A Mascola, James Baggs, Frank DeStefano, T Craig Cheetham, Lisa A Jackson, Allison L Naleway, Jason M Glanz, James D Nordin, Edward A Belongia, Vaccine Safety Datalink Trivalent inactivated influenza vaccine and spontaneous abortion. Obstet Gynecol: 2013, 121(1);159-65 PubMed 23262941
  3. F Rubinstein, P Micone, A Bonotti, V Wainer, A Schwarcz, F Augustovski, A Pichon Riviere, A Karolinski, EVA Study Research Group Estudio Embarazo y Vacuna Antigripal Influenza A/H1N1 MF59 adjuvanted vaccine in pregnant women and adverse perinatal outcomes: multicentre study. BMJ: 2013, 346;f393 PubMed 23381200
  4. John P Mullooly, Roberleigh Schuler, Jill Mesa, Lois Drew, Frank DeStefano, VSD team Wheezing lower respiratory disease and vaccination of premature infants. Vaccine: 2011, 29(44);7611-7 PubMed 21875634


Vaccine is the journal for those interested in vaccines and vaccination. Homepage | PubMed


Pina Bozzo, Andrea Narducci, Adrienne Einarson Vaccination during pregnancy. Can Fam Physician: 2011, 57(5);555-7 PubMed 21571717

Jean Hamlin, Selvi Senthilnathan, Henry H Bernstein Update on universal childhood immunizations. Curr. Opin. Pediatr.: 2008, 20(4);483-9 PubMed 18622208


PMID 23364302 | MMWR Recomm Rep. Huan Pham, Stephen A Geraci, Mary Jane Burton, CDC Advisory Committee on Immunization Practices Adult immunizations: update on recommendations. Am. J. Med.: 2011, 124(8);698-701 PubMed 21658665

External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.



United Kingdom


Glossary Links

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols

Cite this page: Hill, M.A. 2017 Embryology Postnatal - Vaccination. Retrieved March 30, 2017, from

What Links Here?
© Dr Mark Hill 2017, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G