Lecture - Integumentary Development
The skin provides a barrier between ourselves and our environment (temperature, water, UV), and contains specializations in different regions including hair, nails, teeth, glands and sensory receptors. In other species there are also specializations of beaks, scales and feathers.
The two major tissue organizations of epithelial (ectoderm, epidermis) and mesenchyme (mesoderm connective tissue, dermis and hypodermis) are shown within skin. In addition, we have also have extensive populating by melanocytes (neural crest) and sensory nerve endings.
Possibly the first epithelial tissue specialization from which arose other epithelial specializations now located inside the body. The external skin associated structures have many different roles and functions. This system is also an excellent model for distribution or "pattern" and adult stem cells.
This lecture will be presented by a SOMS researcher Dr. Annemiek Beverdam specialising in Integumentary and Stem Cell Development. Her lecture slides are linked below.
Shown below on this page is for only background information for this topic.
Skin structure cartoon
- Developmental Biology 6th ed. Gilbert, Scott F. Sunderland (MA): Sinauer Associates, Inc.; c2000. Development of the hair follicles in fetal human skin | Image - Coordinated differentiation and morphogenesis in the mammalian tooth | Tooth Development
- Eurekah Bioscience Collection Role of GLI proteins in embryonic hair follicle development
- Molecular Biology of the Cell FGF5 is a negative regulator of hair formation
- Blue Histology Integumentary System
dermal papilla - the extensions of the dermis into the epidermis.
dermatoglyphic patterns - (Greek, derma = "skin", glyph = "carving") fingers, palms, toes, and soles skin patterns.
epidermal growth factor receptor - expressed on cells in the epidermis basal layer, signaling stimulates both epidermal growth and wound healing and also mediates an inhibition of differentiation.
rete ridge - the extensions of the epidermis into the dermis. These epidermal surface thickenings extend downward between underlying connective tissue dermal papillae. This is also the site of initial eccrine gland differentiation.
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- Teeth - University of Helsinki - Gene Expression in Tooth | American Dental Association Overview - Tooth | Columbia University Medical Centre - Illustrations: How a Tooth Decays | Merck - Tooth disorders | Nemours Foundation - Teething Tots
Olivier Duverger, Maria I Morasso Role of homeobox genes in the patterning, specification, and differentiation of ectodermal appendages in mammals. J. Cell. Physiol.: 2008, 216(2);337-46 PubMed 18459147
|2017 ANAT2341 - Timetable | Course Outline | Group Projects | Moodle | Tutorial 1 | Tutorial 2 | Tutorial 3|
Labs: 1 Fertility and IVF | 2 ES Cells to Genome Editing | 3 Preimplantation and Early Implantation | 4 Reproductive Technology Revolution | 5 Cardiac and Vascular Development | 6 CRISPR-Cas9 | 7 Somitogenesis and Vertebral Malformation | 8 Organogenesis | 9 | 10 | 11
Lectures: 1 Introduction | 2 Fertilization | 3 Week 1/2 | 4 Week 3 | 5 Ectoderm | 6 Placenta | 7 Mesoderm | 8 Endoderm | 9 Research Technology | 10 Cardiovascular | 11 Respiratory | 12 Neural crest | 13 Head | 14 Musculoskeletal | 15 Limb | 16 Renal | 17 Genital | 18 Endocrine
|Student Projects: 1 Cortex | 2 Kidney | 3 Heart | 4 Eye | 5 Lung | 6 Cerebellum|