Hearing - Neural Pathway

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Introduction

Central auditory neural pathway
Central auditory neural pathway

This diagram gives an overview of the central neural pathway from the cochlea through the brainstem nuclei to the auditory cortex. Note that this neural pathway can be analysed postnatally by Automated Auditory Brainstem Response.


  1. auditory nerve (cochlear nerve, acoustic nerve) part of the vestibulocochlear nerve (8th cranial nerve, CN VIII)
  2. cochlear nuclei (dorsal cochlear nucleus, ventral cochlear nucleus)
  3. superior olivary complex (SOC, superior olive)
  4. lateral lemniscus
  5. inferior colliculus
  6. medial geniculate nucleus
  7. auditory cortex


Hearing Links: Introduction | inner ear | middle ear | outer ear | balance | placode | hearing neural | Science Lecture | Lecture Movie | Medicine Lecture | Stage 22 | hearing abnormalities | hearing test | sensory | Student project

  Categories: Hearing | Outer Ear | Middle Ear | Inner Ear | Balance

Historic Hearing Embryology 
Historic Embryology: 1880 Platypus cochlea | 1902 Development of Hearing | 1906 Membranous Labyrinth | 1910 Auditory Nerve | 1913 Tectorial Membrane | 1918 Human Embryo Otic Capsule | 1918 Cochlea | 1918 Grays Anatomy | 1922 Human Auricle | 1922 Otic Primordia | 1931 Internal Ear Scalae | 1932 Otic Capsule 1 | 1933 Otic Capsule 2 | 1936 Otic Capsule 3 | 1933 Endolymphatic Sac | 1934 Otic Vesicle | 1934 Membranous Labyrinth | 1938 Stapes - 7 to 21 weeks | 1938 Stapes - Term to Adult | 1942 Stapes - Embryo 6.7 to 50 mm | 1943 Stapes - Fetus 75 to 150 mm | 1948 Stapes - Fetus 160 mm to term | 1959 Auditory Ossicles | 1963 Human Otocyst | Historic Disclaimer


Some Recent Findings

  • Effects of transient auditory deprivation during critical periods on the development of auditory temporal processing[1] "The central auditory pathway matures through sensory experiences and it is known that sensory experiences during periods called critical periods exert an important influence on brain development. The present study aimed to investigate whether temporary auditory deprivation during critical periods could have a detrimental effect on the development of auditory temporal processing. MATERIALS AND METHODS: Twelve neonatal rats were randomly assigned to control and study groups; Study group experienced temporary (18-20 days) auditory deprivation during critical periods (Early deprivation study group). Outcome measures included changes in auditory brainstem response (ABR), gap prepulse inhibition of the acoustic startle reflex (GPIAS), and gap detection threshold (GDT). To further delineate the specific role of CPs in the outcome measures above, the same paradigm was applied in adult rats (Late deprivation group) and the findings were compared with those of the neonatal rats. RESULTS: Soon after the restoration of hearing, early deprivation study animals showed a significantly lower GPIAS at intermediate gap durations and a larger GDT than early deprivation controls, but these differences became insignificant after subsequent auditory inputs. Additionally, the ABR results showed significantly delayed latencies of waves IV, V, and interpeak latencies of wave I-III and wave I-V in study group. Late deprivation group didn't exhibit any deterioration in temporal processing following sensory deprivation. CONCLUSION: Taken together, the present results suggest that transient auditory deprivation during critical periods might cause reversible disruptions in the development of temporal processing." Rat Development
  • Myelin development, plasticity, and pathology in the auditory system[2] "Myelin allows for the rapid and precise timing of action potential propagation along neuronal circuits and is essential for healthy auditory system function. In this article, we discuss what is currently known about myelin in the auditory system with a focus on the timing of myelination during auditory system development, the role of myelin in supporting peripheral and central auditory circuit function, and how various myelin pathologies compromise auditory information processing. Additionally, in keeping with the increasing recognition that myelin is dynamic and is influenced by experience throughout life, we review the growing evidence that auditory sensory deprivation alters myelin along specific segments of the brain's auditory circuit." hearing test
  • The precise temporal pattern of prehearing spontaneous activity is necessary for tonotopic map refinement[3] "Patterned spontaneous activity is a hallmark of developing sensory systems. In the auditory system, rhythmic bursts of spontaneous activity are generated in cochlear hair cells and propagated along central auditory pathways. The role of these activity patterns in the development of central auditory circuits has remained speculative....These results provide evidence that the precise temporal pattern of spontaneous activity before hearing onset is crucial for the establishment of precise tonotopy, the major organizing principle of central auditory pathways."
  • Formation and maturation of the calyx of Held[4] "Sound localization requires precise and specialized neural circuitry. A prominent and well-studied specialization is found in the mammalian auditory brainstem. Globular bushy cells of the ventral cochlear nucleus (VCN) project contralaterally to neurons of the medial nucleus of the trapezoid body (MNTB), where their large axons terminate on cell bodies of MNTB principal neurons, forming the calyces of Held. The VCN-MNTB pathway is necessary for the accurate computation of interaural intensity and time differences; MNTB neurons provide inhibitory input to the lateral superior olive, which compares levels of excitation from the ipsilateral ear to levels of tonotopically matched inhibition from the contralateral ear, and to the medial superior olive, where precise inhibition from MNTB neurons tunes the delays of binaural excitation. ... In rodents, immature calyces of Held appear in MNTB during the first few days of postnatal life. These calyces mature morphologically and physiologically over the next three postnatal weeks, enabling fast, high fidelity transmission in the VCN-MNTB pathway."
More recent papers
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This table shows an automated computer PubMed search using the listed sub-heading term.

  • Therefore the list of references do not reflect any editorial selection of material based on content or relevance.
  • References appear in this list based upon the date of the actual page viewing.

References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.

Links: References | Discussion Page | Pubmed Most Recent | Journal Searches


Search term: Hearing Neural Pathway Development

Michael Lohse, Victoria M Bajo, Andrew J King Development, Organization and Plasticity of Auditory Circuits: Lessons from a Cherished Colleague. Eur. J. Neurosci.: 2018; PubMed 29804304

Nihaad Paraouty, Arkadiusz Stasiak, Christian Lorenzi, Leo Varnet, Ian M Winter DUAL CODING OF FREQUENCY MODULATION IN THE VENTRAL COCHLEAR NUCLEUS. J. Neurosci.: 2018; PubMed 29599389

Rachel I Mayberry, Tristan Davenport, Austin Roth, Eric Halgren Neurolinguistic processing when the brain matures without language. Cortex: 2018, 99;390-403 PubMed 29406150

Duncan M Chadly, Jennifer Best, Cong Ran, Małgorzata Bruska, Witold Woźniak, Bartosz Kempisty, Mark Schwartz, Bonnie LaFleur, B J Kerns, John A Kessler, Akihiro J Matsuoka Developmental profiling of microRNAs in the human embryonic inner ear. PLoS ONE: 2018, 13(1);e0191452 PubMed 29373586

Bong Jik Kim, Jungyoon Kim, Il-Yong Park, Jae Yun Jung, Myung-Whan Suh, Seung-Ha Oh Effects of transient auditory deprivation during critical periods on the development of auditory temporal processing. Int. J. Pediatr. Otorhinolaryngol.: 2018, 104;66-71 PubMed 29287884

Keith1902 fig046.jpg

Mass of nerve cells is divided into three groups.

A Geniculate ganglion (taste group, motor and sympathetic) B Spiral ganglion (cochlear group) C Vestibular ganglion (balance group)

Vestibulocochlear Nerve

Afferent (sensory) cranial nerve brainstem primary terminal nuclei
Adult cochlea cartoon 01.jpg
Adult cochlea nerve glia diagram[5]
  • forms beside otocyst
  • from wall of otocyst and neural crest cells
  • bipolar neurons

Vestibular Neurons

  • outer end of internal acoustic meatus
  • innervate hair cells in membranous labyrinth
  • axons project to brain stem and synapse in vestibular nucleus

Cochlear Neurons

  • cell bodies lie in modiolus
  • central pillar of cochlear
  • innervate hair cells of spiral organ
  • axons project to cochlear nucleus

Cochlea Glial

Cochlea glial lineage cartoon.jpg Adult cochlea nerve glia cartoon.jpg
Cochlea glial lineage[5] Adult cochlea nerve glia cartoon[5]


Auditory Sound Localization Circuits in the Mammalian Brainstem

Hearing sound localization circuits brainstem.jpg

Schematic drawing of primary auditory sound localization circuits in the mammalian brainstem. For clarity, only the LSO or MSO are shown on each side.[6]

Except for the auditory nerve, excitatory connections are shown in green and inhibitory connections are shown in red.

  • AN - auditory nerve
  • CN - cochlear nucleus
  • HF - high frequency
  • LF - low frequency


Links: Hearing - Inner Ear Development


Calyx of Held

A specialised mammalian auditory brainstem synaptic structure.[7] Ventral cochlear nucleus (VCN) globular bushy cells project to the contralateral, but not ipsilateral, medial nucleus of the trapezoid body (MNTB), where they form this specialised structure, named by Hans Held (1893).[8] The VCN-MNTB pathway is required for calculating the interaural intensity and time differences.

References

  1. Kim BJ, Kim J, Park IY, Jung JY, Suh MW & Oh SH. (2018). Effects of transient auditory deprivation during critical periods on the development of auditory temporal processing. Int. J. Pediatr. Otorhinolaryngol. , 104, 66-71. PMID: 29287884 DOI.
  2. Long P, Wan G, Roberts MT & Corfas G. (2018). Myelin development, plasticity, and pathology in the auditory system. Dev Neurobiol , 78, 80-92. PMID: 28925106 DOI.
  3. Clause A, Kim G, Sonntag M, Weisz CJ, Vetter DE, Rűbsamen R & Kandler K. (2014). The precise temporal pattern of prehearing spontaneous activity is necessary for tonotopic map refinement. Neuron , 82, 822-35. PMID: 24853941 DOI.
  4. Roy PN, Mehra KS & Deshpande PJ. (1975). Cataract surgery performed before 800 B.C. Br J Ophthalmol , 59, 171. PMID: 1093567
  5. 5.0 5.1 5.2 Locher H, de Groot JC, van Iperen L, Huisman MA, Frijns JH & Chuva de Sousa Lopes SM. (2014). Distribution and development of peripheral glial cells in the human fetal cochlea. PLoS ONE , 9, e88066. PMID: 24498246 DOI.
  6. Kandler K, Clause A & Noh J. (2009). Tonotopic reorganization of developing auditory brainstem circuits. Nat. Neurosci. , 12, 711-7. PMID: 19471270 DOI.
  7. Nakamura PA & Cramer KS. (2011). Formation and maturation of the calyx of Held. Hear. Res. , 276, 70-8. PMID: 21093567 DOI.
  8. Held H. Die zentrale Gehörleitung. (The Central Auditory Pathway) Arch Anat Physiol Anat Abtheil. 1893;17:201–248.


Reviews

Kandler K, Clause A & Noh J. (2009). Tonotopic reorganization of developing auditory brainstem circuits. Nat. Neurosci. , 12, 711-7. PMID: 19471270 DOI.

Articles

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Cite this page: Hill, M.A. (2018, June 21) Embryology Hearing - Neural Pathway. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Hearing_-_Neural_Pathway

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© Dr Mark Hill 2018, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G