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Lab Attendance

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2015 Course: Week 2 Lecture 1 Lecture 2 Lab 1 | Week 3 Lecture 3 Lecture 4 Lab 2 | Week 4 Lecture 5 Lecture 6 Lab 3 | Week 5 Lecture 7 Lecture 8 Lab 4 | Week 6 Lecture 9 Lecture 10 Lab 5 | Week 7 Lecture 11 Lecture 12 Lab 6 | Week 8 Lecture 13 Lecture 14 Lab 7 | Week 9 Lecture 15 Lecture 16 Lab 8 | Week 10 Lecture 17 Lecture 18 Lab 9 | Week 11 Lecture 19 Lecture 20 Lab 10 | Week 12 Lecture 21 Lecture 22 Lab 11 | Week 13 Lecture 23 Lecture 24 Lab 12 | 2015 Projects: Three Person Embryos | Ovarian Hyper-stimulation Syndrome | Polycystic Ovarian Syndrome | Male Infertility | Oncofertility | Preimplantation Genetic Diagnosis | Students | Student Designed Quiz Questions | Moodle page

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Week 1 Assessment

1) PMID 18603501

2) PMID 21793811

Impact of endometriosis on in vitro fertilization and embryo transfer cycles in young women; a stage-dependent interference

Due to the significantly higher prevalence of endometriosis in infertile women as compared to the general population, a causal relationship between endometriosis and infertility has been postulated. In vitro fertilisation and embryo transfer (IVF-ET) has been considered a suitable treatment for patients with a history of endometriosis. This study examines the effect of endometriosis on IVF-ET cycles on women younger than 35 years of age and who have had surgical treatment for endometriosis without clinical recurrence signs. The endometriosis group was compared to another group of patients also undergoing IVF-ET, but with tubal infertility without clinical signs of endometriosis. The results were analysed according to the different stages of endometriosis as classified by the American Society for Reproductive Medicine.

The experimental group consisted of 148 patients whereas the control group (tubal infertility patients) consisted of 72 patients. All groups consisted of patients that were less than 35 years of age and did not have clinical indication for any other cause of infertility. The experimental group underwent 164 IVF-ET cycles while the control group underwent 80 IVF-ET cycles. Patients received a long-acting down-regulation drug regime, a daily subcutaneous FSH dose, as well as gonadotropin doses which were decided individually according to age, basal FSH, ovarian volume and ovarian response. After two or more follicles reached maximal diameter of 17-18mm, hCG was administered and oocytes were obtained 36 hours later using vaginal ultrasonography, to then be fertilised on the same day. Embryo transfers were made two to three days after oocyte retrieval. Natural progesterone in oil was then administered. Plasma beta-hCG values were used to assess pregnancy. Clinical pregnancy was determined when at least one gestational sac was found with a fetal pole and heart activity through ultrasond.

It was found that the experimental group had significantly lower numbers of follicles on the hCG day, oocytes obtained and transferred when compared to the control group, despite receiving a higher FSH dose. However no significant differences were found regardingt cycle cancellation rate, peak E2 levels of the length of the stimulation phase. 11.6% of clinical pregnancies per started cucle were observed in the experimental group as compared to 22.5% in the control group. However, this value wa not significant when the clinical pregnancy rate was considered per oocyte retrieval or per embryo transfer. It was also found that patients at stage I-II of endomtriosis had a significantly lower rate of fertilisation when compared to the control group patients. Patients at stage III-IV of endometriosis had a large reduction in pregnancy rate than the control group, however the fertilisation rate was comparable. Patients at stage III-IV had lower peak E2 concentrations, less follicles on the hCG day, fewer oocytes at retrieval and lower implantation rates. Furthermore, poor ovarion responses in 15 out of 109 cycles resulted in discontinuation of the cycle in patients at stage III-IV of the endometriosis group, compared to 2 of 55 in the stage I-II group and 3 of 80 in the control group. Test student 2015

References

PMID 26244658 look at this <ref><pubmed>26244658</pubmed>

here's the list