Template:Main Page News: Difference between revisions

Revision as of 07:48, 29 September 2017

News - Zika Virus

A single mutation in the prM protein of Zika virus contributes to fetal microcephaly

"Here, we show that a single serine to asparagine substitution (S139N) in the viral polyprotein substantially increased ZIKV infectivity in both human and mouse neural progenitor cells (NPCs), led to more significant microcephaly in the mouse fetus, and higher mortality in neonatal mice. Evolutionary analysis indicates that the S139N substitution arose before the 2013 outbreak in French Polynesia and has been stably maintained during subsequent spread to the Americas. "

A single mutation in the prM protein of Zika virus contributes to fetal microcephaly Science 28 Sep 2017: eaam7120 DOI: 10.1126/science.aam7120

Links: Zika Virus

Historic Embryology - Viral
1941 Rubella Cataracts \| 1944 Rubella Defects

@@ Line 1: / Line 1: @@
 {| width=700px|
 |-bgcolor="CEDFF2"
-| <span style="font-size:150%">'''News - CRISPR Gene Editing'''</span>
+| <span style="font-size:150%">'''News - Zika Virus'''</span>
 |-bgcolor="F5FAFF"
-| valign=top| [[File:CRISPR Cas9 interaction with target DNA.jpg|250px|right|alt=CRISPR Cas9 interaction with target DNA|link=Molecular_Development_-_Genetics#CRISPR]]
+| valign=top|
+[[File:Mosquito lifecycle.jpg|400px|250px|right|alt=Mosquito lifecycle|link=Abnormal Development - Zika Virus]]
-It has been reported (but not confirmed by publication) that USA scientists have [https://www.technologyreview.com/s/608350/first-human-embryos-edited-in-us/amp/ gene-edited embryos using CRISPR]. This follows on from an earlier 2015 published work ([https://www.ncbi.nlm.nih.gov/pubmed/25894090 PMID 25894090]) from China using the same technique [http://www.nature.com/news/chinese-scientists-genetically-modify-human-embryos-1.17378 see Nature 22 April 2015] and a more recent 2017 paper ([https://www.ncbi.nlm.nih.gov/pubmed/?term=28251317 PMID 28251317]).
+'''A single mutation in the prM protein of Zika virus contributes to fetal microcephaly'''
-See also editing in the mouse zygote ([https://www.ncbi.nlm.nih.gov/pubmed/?term=25819794  PMID 25819794]).
+:"Here, we show that a single serine to asparagine substitution (S139N) in the viral polyprotein substantially increased ZIKV infectivity in both human and mouse neural progenitor cells (NPCs), led to more significant microcephaly in the mouse fetus, and higher mortality in neonatal mice. Evolutionary analysis indicates that the S139N substitution arose before the 2013 outbreak in French Polynesia and has been stably maintained during subsequent spread to the Americas. "
-'''About CRISPR'''
+[http://science.sciencemag.org/content/early/2017/09/27/science.aam7120 A single mutation in the prM protein of Zika virus contributes to fetal microcephaly] Science  28 Sep 2017: eaam7120 DOI: 10.1126/science.aam7120
-The CRISPR/Cas9-mediated gene editing system was derived from the adaptive immune system evolved in bacteria to defend against invading plasmids and viruses.
+:'''Links:''' [[Abnormal Development - Zika Virus|Zika Virus]]
-:'''Links:''' [[Molecular_Development_-_Genetics#CRISPR|CRISPR]] | [[Molecular_Development_-_Genetics|Genetics]]
+{{Viral Links}}
 |-
 |
-:[[Template_talk:Main_Page_News|'''Older News Articles''']] - [[Template_talk:Main_Page_News#February|Gestational Diabetes]] | [[Template_talk:Main_Page_News#September|Kyoto eBook]] | [[Template_talk:Main_Page_News#August|Dolly's sisters live on!]] | [[Template_talk:Main_Page_News#June|Thalidomide in Zebrafish]]  | [[Template_talk:Main_Page_News#March|Human pancreas stem cells]] | [[Template_talk:Main_Page_News#January|Oral contraceptive no risk of major birth defects]] | [[Template_talk:Main_Page_News#September|Maternal Malaria Neurovascular Development Effects]] | [[Template_talk:Main_Page_News#June|Oocyte/Spermatozoa fate decision]] [[Template_talk:Main_Page_News#April|Rubella eliminated in the Americas]] | [[Template_talk:Main_Page_News#February|Three-person embryos]]
+:[[Template_talk:Main_Page_News|'''Older News Articles''']] - [[Template_talk:Main_Page_News#July|CRISPR]] | [[Template_talk:Main_Page_News#February|Gestational Diabetes]] | [[Template_talk:Main_Page_News#September|Kyoto eBook]] | [[Template_talk:Main_Page_News#August|Dolly's sisters live on!]] | [[Template_talk:Main_Page_News#June|Thalidomide in Zebrafish]]  | [[Template_talk:Main_Page_News#March|Human pancreas stem cells]] | [[Template_talk:Main_Page_News#January|Oral contraceptive no risk of major birth defects]] | [[Template_talk:Main_Page_News#September|Maternal Malaria Neurovascular Development Effects]] | [[Template_talk:Main_Page_News#June|Oocyte/Spermatozoa fate decision]] [[Template_talk:Main_Page_News#April|Rubella eliminated in the Americas]] | [[Template_talk:Main_Page_News#February|Three-person embryos]]
 |}