Somatic Cell Nuclear Transfer: Difference between revisions

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'''''Page Under Development'''''
'''''Page Under Development'''''
[[File:Dolly the sheep.jpg|thumb|Dolly the Sheep]]
[[File:Dolly the sheep.jpg|thumb|Dolly the Sheep]]
[[Image:Mice cloned from adult keratinocytes.jpg|thumb|Mice cloned from adult keratinocytes<ref><pubmed>17299040</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1815251 PMC1815251]</ref>]]


In 1996 Dolly the sheep was the first animal to be produced by somatic cell nuclear transfer (SCNT) using an adult-derived somatic cell as nuclear donor. A somatic cell refers to the fact that a cell that is not a germ cell (spermatozoa, oocyte) is used to generate a zygote from which the embryo develops.
In 1996 Dolly the sheep was the first animal to be produced by somatic cell nuclear transfer (SCNT) using an adult-derived somatic cell as nuclear donor. A somatic cell refers to the fact that a cell that is not a germ cell (spermatozoa, oocyte) is used to generate a zygote from which the embryo develops.
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A range of different cell types has now been successfully applied to a range of species (cattle, mice, goats, pigs, cats, rabbits, horses, rats, dogs and ferrets. (see review<ref><pubmed>22681293</pubmed></ref>)
A range of different cell types has now been successfully applied to a range of species (cattle, mice, goats, pigs, cats, rabbits, horses, rats, dogs and ferrets. (see review<ref><pubmed>22681293</pubmed></ref>)


:[[Somatic Cell Nuclear Transfer|'''SCNT Links''': [[Somatic Cell Nuclear Transfer|Introduction]] | [[Stem_Cells_-_Adult#Somatic_Cell_Nuclear_Transfer|Stem Cells - SCNT]] | [[Molecular_Development_-_Epigenetics|Epigenetics]] | [[Stem Cells]] | [[Assisted Reproductive Technology|ART]] | [[Fertilization]] | [[Week 1]] | [[:Category:Zygote|Category:Zygote]]
:[[Somatic Cell Nuclear Transfer|'''SCNT Links''']]: [[Somatic Cell Nuclear Transfer|Introduction]] | [[Stem_Cells_-_Adult#Somatic_Cell_Nuclear_Transfer|Stem Cells - SCNT]] | [[Molecular_Development_-_Epigenetics|Epigenetics]] | [[Stem Cells]] | [[Assisted Reproductive Technology|ART]] | [[Fertilization]] | [[Week 1]] | [[:Category:Zygote|Category:Zygote]]
 


== Some Recent Findings ==
== Some Recent Findings ==

Revision as of 13:09, 22 August 2012

Introduction

Page Under Development

Dolly the Sheep
Mice cloned from adult keratinocytes[1]

In 1996 Dolly the sheep was the first animal to be produced by somatic cell nuclear transfer (SCNT) using an adult-derived somatic cell as nuclear donor. A somatic cell refers to the fact that a cell that is not a germ cell (spermatozoa, oocyte) is used to generate a zygote from which the embryo develops.

A range of different cell types has now been successfully applied to a range of species (cattle, mice, goats, pigs, cats, rabbits, horses, rats, dogs and ferrets. (see review[2])

SCNT Links: Introduction | Stem Cells - SCNT | Epigenetics | Stem Cells | ART | Fertilization | Week 1 | Category:Zygote

Some Recent Findings

  • Number of blastomeres and distribution of microvilli in cloned mouse embryos during compaction[3] "We concluded that: (i) the cleavage of blastomeres in cloned embryos was slow at least before compaction; (ii) the distribution of microvilli in cloned, normal, parthenogenetic, and tetraploid embryos was coherent before and after compaction; and (iii) the initiation of compaction in somatic cell nuclear transfer (SCNT) embryos was delayed compared with that of intracytoplasmic sperm injection (ICSI) embryos."


Animal Timeline


References

  1. ↑ <pubmed>17299040</pubmed>| PMC1815251
  2. ↑ <pubmed>22681293</pubmed>
  3. ↑ <pubmed>20735894</pubmed>
  4. ↑ <pubmed>8598906</pubmed>
  5. ↑ <pubmed>9596577</pubmed>
  6. ↑ <pubmed>9690471</pubmed>
  7. ↑ <pubmed>10331804</pubmed>
  8. ↑ <pubmed>10993078</pubmed>

Journals

  • Zygote An international journal dedicated to the rapid publication of original research in early embryology, Zygote covers interdisciplinary studies in animals and humans, from gametogenesis through fertilization to gastrulation.

Reviews

Articles

Search Pubmed

June 2010 "zygote" All (6213) Review (651) Free Full Text (1543)

Search Pubmed: somatic cell nuclear transfer


Glossary Links

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Cite this page: Hill, M.A. (2024, April 26) Embryology Somatic Cell Nuclear Transfer. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Somatic_Cell_Nuclear_Transfer

What Links Here?
© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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